HEAT6_MOUSE
ID HEAT6_MOUSE Reviewed; 1184 AA.
AC Q6P1G0; Q3UUN8; Q99KZ5; Q9CSQ4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=HEAT repeat-containing protein 6;
GN Name=Heatr6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-321 AND 887-1181.
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH03942.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL663075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003942; AAH03942.1; ALT_INIT; mRNA.
DR EMBL; BC065092; AAH65092.1; -; mRNA.
DR EMBL; AK012216; BAB28103.3; -; mRNA.
DR EMBL; AK138219; BAE23587.1; -; mRNA.
DR CCDS; CCDS36259.1; -.
DR RefSeq; NP_663407.2; NM_145432.3.
DR AlphaFoldDB; Q6P1G0; -.
DR BioGRID; 229833; 2.
DR IntAct; Q6P1G0; 2.
DR MINT; Q6P1G0; -.
DR STRING; 10090.ENSMUSP00000001002; -.
DR iPTMnet; Q6P1G0; -.
DR PhosphoSitePlus; Q6P1G0; -.
DR EPD; Q6P1G0; -.
DR jPOST; Q6P1G0; -.
DR MaxQB; Q6P1G0; -.
DR PaxDb; Q6P1G0; -.
DR PeptideAtlas; Q6P1G0; -.
DR PRIDE; Q6P1G0; -.
DR ProteomicsDB; 269780; -.
DR Antibodypedia; 31155; 59 antibodies from 11 providers.
DR Ensembl; ENSMUST00000001002; ENSMUSP00000001002; ENSMUSG00000000976.
DR GeneID; 217026; -.
DR KEGG; mmu:217026; -.
DR UCSC; uc007kpt.1; mouse.
DR CTD; 63897; -.
DR MGI; MGI:1919790; Heatr6.
DR VEuPathDB; HostDB:ENSMUSG00000000976; -.
DR eggNOG; KOG4535; Eukaryota.
DR GeneTree; ENSGT00390000016675; -.
DR HOGENOM; CLU_007141_1_0_1; -.
DR InParanoid; Q6P1G0; -.
DR OMA; KPYICHK; -.
DR OrthoDB; 106835at2759; -.
DR PhylomeDB; Q6P1G0; -.
DR TreeFam; TF324244; -.
DR BioGRID-ORCS; 217026; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Heatr6; mouse.
DR PRO; PR:Q6P1G0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6P1G0; protein.
DR Bgee; ENSMUSG00000000976; Expressed in ear vesicle and 240 other tissues.
DR Genevisible; Q6P1G0; MM.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025283; DUF4042.
DR Pfam; PF13251; DUF4042; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..1184
FT /note="HEAT repeat-containing protein 6"
FT /id="PRO_0000337174"
FT REPEAT 159..198
FT /note="HEAT 1"
FT REPEAT 455..493
FT /note="HEAT 2"
FT REPEAT 517..555
FT /note="HEAT 3"
FT REPEAT 561..598
FT /note="HEAT 4"
FT REGION 292..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AI08"
FT MOD_RES 405
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AI08"
FT MOD_RES 621
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:A1EC95"
FT MOD_RES 646
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AI08"
SQ SEQUENCE 1184 AA; 128922 MW; 64A78EB3ADE61CA7 CRC64;
MAAVQVAASL PCGQPREAPR ELSPEQDDGF RRLSARLRAL QPDDSTVSRM EIHLLFDQLI
SENYSEGGGV APEDVSALLV RACQLVPLNQ NHLVSKVCQL IHRLLNRLQV VVDEPNLDFL
LTYTISALQQ CSSWTHMEIL QALAALVYCN GSKCQKHLPD LLGKSGLLMK LSDLSHSDPE
VRRAAVHCMA NLCLSVPGQP YLEEPYQHVC FQAFLTILQS PKSSDMDDIT FCMLLQNALK
GIQSLLNGGK MRLTQTEHLG ALLAVLKKAM FHGLPGLNIE MPAVLYPTPL PQYDGRSPVK
PQQPESTTAR SSANKKKKHK VKTKKTQQGE KAEEEEEEPC GEVEAAPGLS MDQANVSGES
AWCSSPWGSQ GLPVDGGRAA GREQASLPFA SSSWKRVSSS ESDYSDAEGG MQGKMRSYQA
KVRQGALACF LSTIKSIEKK VLYGYWSAFV PDTPELGSPQ SVSLMTLTLK DPSPKTRACA
LQVLSAILEG SKQFLSVAED TSDHKRAFTP FSVTIASSIR ELHRCLLLAL VAESSSQTLT
QIIKCLANLV SNAPYNRLKL SLLTKVWNHI KPYIRHKDVN VRVSSLTLLG AIVSTHAPLP
EVQLLLQQPC SSGLSSSSSA TPHLSTPDGW KTFPAGSSLE EASLSSPKGS SEPCWLIRLC
ISTVVLPKED SCSGSDAGSA LGSTYEPSPM RLEALQVLAH LARGYFSTAQ LYLMELGEVI
CKCMCEANPS IQLHGVKLLE ELGAGLIQQY KPDSNIAPEQ RVPVHLVVVF WTAMLSGPLP
RALQSAEHPT LQASACDALS SILPEAFSSL PNDKQILCIT VLLGLNDSKN HLVKAATSRA
LGVYVLFPCL RQDVIFVADT ANAILMSLQD KSLNVRAKAA WSLGNLTDTL IVNMDTPDPS
FQDEFSGLLL LKMLQCAIQA STDKDKVKSN AVRALGNLLH FLQPSHVERP RFAEIIEESI
QALISTVVNE AAMKVRWNAC YAMGNVFKNP ALPLGTAPWT SQAYKALTSV VMSCKNFKVR
IRSAAALSVP SKRGQYGSLE QFIQIWSALV TALQKSEDTT DFLEFKYCAS LRTHICQALL
HLLSLASASD LPGIQETLKL HGDMIRSYIL QFLKSGAEGD DPGAVHTPQE RVQMVRVALK
HIHRVQTLAG DTARGAIMGF LEDILTVHCD SSGEQVMLRG PSDQ
