ID   HEAT6_PONAB             Reviewed;        1181 AA.
AC   Q5R5R2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=HEAT repeat-containing protein 6;
GN   Name=HEATR6;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CR860794; CAH92904.1; -; mRNA.
DR   RefSeq; NP_001126706.1; NM_001133234.1.
DR   AlphaFoldDB; Q5R5R2; -.
DR   STRING; 9601.ENSPPYP00000009563; -.
DR   GeneID; 100173706; -.
DR   KEGG; pon:100173706; -.
DR   CTD; 63897; -.
DR   eggNOG; KOG4535; Eukaryota.
DR   InParanoid; Q5R5R2; -.
DR   OrthoDB; 106835at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR025283; DUF4042.
DR   Pfam; PF13251; DUF4042; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..1181
FT                   /note="HEAT repeat-containing protein 6"
FT                   /id="PRO_0000337175"
FT   REPEAT          159..198
FT                   /note="HEAT 1"
FT   REPEAT          452..490
FT                   /note="HEAT 2"
FT   REPEAT          514..552
FT                   /note="HEAT 3"
FT   REPEAT          558..595
FT                   /note="HEAT 4"
FT   REGION          294..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          613..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..404
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         336
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AI08"
FT   MOD_RES         337
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AI08"
FT   MOD_RES         399
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AI08"
FT   MOD_RES         402
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AI08"
FT   MOD_RES         618
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:A1EC95"
FT   MOD_RES         643
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AI08"
SQ   SEQUENCE   1181 AA;  128596 MW;  A9C55EE7E41A32AD CRC64;
     MAAVQVVGSL PSGQLREAPR DAIPEGGNGF RRLSARLCAL RPDDSSSART EIHLLFDQLI
     SENYSEGSGV APEDVSALLV QACRLVPLNQ NHLVSKVSQL IHHLLNRLQV IVDEQRLDFL
     LAYTISAIHQ CSSWTHMEIL QALAALVYCN GSKCQKYLLE LLGETGLLMK LSDLAQSDPE
     VRRAAVHCMA NLCLSVPGQP YLEEPYQNVC FQAFLTILQS PKSSDMDDIT FCMLLQNALK
     GIQSLLNGGR MKLTQTDELG ALLAVLKKFM FHGLPGLNIE MPMVLYPTPL PQYDGRTPIK
     PQQSESSASR PTLNKKKKSK VKPKKIQQGE EEEKESSGEI EAAPVTGTGR VNLHEGNTWC
     PSSLGVQSLP LDGSGAAGKD GVSSPFSSSS WKRVSSSESD FSDAEGGMQS KMRSYQAKVR
     QVALVCFLST IKSIEKKVLY GYWSAFIPDT PELGSPQSVS LMTLTLKDPS PKTRACALQV
     LSAILEGSKQ FLSVAEDTSD HRRAFTPFSV MIASSIRELH RCLLLALVAE SSSQTLTQII
     KCLANLVSDA PYDRLKLSLL TKVWNQIKPY IRHKDVNVRV SSLTLLGAIV STHAPLPEVQ
     LLLQQPCSSG LSNSNSATPH LSPPDWWKKA PAGPSLEETS VSSPKGSSEP CWLIRLCISI
     VVLPKEDSCS GSDAGSAAGS TYEPSPMRLE ALQVLTLLAR GYFSMTQAYL MELGEVICKC
     MGEADPSIQL HGAKLLEELG TGLIQQYKPD STAAPDQRAP VFLVVMFWTM MLNGPLPRAL
     QNSEHPTLQA GACDALSSIL PEAFSNLPKD RQILCITVLL GLNDSKNRLV KAATSRALGV
     YVLFPCLRQD VIFVADTANA ILMSLEDKSL NVRANAAWSL GNLTDTLIVN METPDPSFQE
     EFSGLLLLKM LRSAIEASKD KDKVKSNAVR ALGNLLHFLQ PSHIEKPTFA EIIEESIQAL
     ISTVLTEAAM KVRWNACYAM GNVFKNPALP LGTAPWTSQA YNALTSVVTS CKNFKVRIRS
     AAALSVPGKR EQYGSVDQYA GIWNALVTAL QKSEDTRDFL EFKYCASLRT QICQALIHLL
     NLASASDLPC IKETLELNGN MVQSYILQFI KSGAEGDDTG APHSPQERDQ MVRMALKHMG
     SIQAPTGDTA RRAVMGFLEE ILAVCFDSSG SQGALPGLTN Q