ID   HEAT6_RAT               Reviewed;        1252 AA.
AC   A1EC95;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=HEAT repeat-containing protein 6;
GN   Name=Heatr6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Dahl salt-sensitive, and Lewis;
RX   PubMed=17218081; DOI=10.1016/j.ygeno.2006.12.005;
RA   Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P.,
RA   Radecki T., Joe B.;
RT   "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous
RT   variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome
RT   10.";
RL   Genomics 89:343-353(2007).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-689 AND SER-714, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
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DR   EMBL; EF122002; ABL63441.1; -; mRNA.
DR   EMBL; EF122003; ABL63442.1; -; mRNA.
DR   RefSeq; NP_001073366.1; NM_001079897.1.
DR   AlphaFoldDB; A1EC95; -.
DR   STRING; 10116.ENSRNOP00000003492; -.
DR   CarbonylDB; A1EC95; -.
DR   iPTMnet; A1EC95; -.
DR   PhosphoSitePlus; A1EC95; -.
DR   jPOST; A1EC95; -.
DR   PaxDb; A1EC95; -.
DR   PeptideAtlas; A1EC95; -.
DR   PRIDE; A1EC95; -.
DR   GeneID; 497972; -.
DR   KEGG; rno:497972; -.
DR   CTD; 63897; -.
DR   RGD; 1566204; Heatr6.
DR   VEuPathDB; HostDB:ENSRNOG00000002542; -.
DR   eggNOG; KOG4535; Eukaryota.
DR   HOGENOM; CLU_007141_1_0_1; -.
DR   InParanoid; A1EC95; -.
DR   OMA; KPYICHK; -.
DR   OrthoDB; 106835at2759; -.
DR   PhylomeDB; A1EC95; -.
DR   TreeFam; TF324244; -.
DR   PRO; PR:A1EC95; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000002542; Expressed in skeletal muscle tissue and 19 other tissues.
DR   Genevisible; A1EC95; RN.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR025283; DUF4042.
DR   Pfam; PF13251; DUF4042; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..1252
FT                   /note="HEAT repeat-containing protein 6"
FT                   /id="PRO_0000337176"
FT   REPEAT          230..269
FT                   /note="HEAT 1"
FT   REPEAT          524..562
FT                   /note="HEAT 2"
FT   REPEAT          586..624
FT                   /note="HEAT 3"
FT   REPEAT          630..667
FT                   /note="HEAT 4"
FT   REGION          365..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         471
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AI08"
FT   MOD_RES         474
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AI08"
FT   MOD_RES         689
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         714
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   1252 AA;  136505 MW;  E2A60C675685CF76 CRC64;
     MSALPGSKLS ERVRTVGWQI SRPYFCHFFP IRITAPPATC SANKGFPELE HARPCPKRCP
     GSISQAIHVG KMAAVQVAAS LPCEQPREAP RELSLEQNNG FRRLSARLRA LQPDDSTVSR
     MEIHLLFDQL ISENYCEGGG VAPEDVSALL VRACQLVPLN QNHLVSKVSQ LIHRLLNRLQ
     VIVDEQNLDF LLTYTISAIQ QCSPWTHMEI LQALAALVYC NGSKCQKHLP DLLGKSGLLM
     KLSDVTHSDP EVRRAAVHCM ANLCLSVPGQ PYLEESYQLV CFQAFLTILQ SPKSSDMDDI
     TFCMLLQNAL KGIQSLLNGG KMRLTQTEHL GALLAVLKKA MFHGLPGLNI EMPAVLYPTP
     LPQYDGRSPV KPQQPESSAA RPSANKKKKY KVKPKKTQQG EKAEEEEPYG EVDAAPGLSM
     DQANTCVESA WCSSPWGSQG LPVDGGRATG REQVSSPFTI SSWKRVSSSE SDYSDAEGGM
     QGKMRSYQAK VRQGALACFL STIKSIEKKV LYGYWSAFVP DTPELGSPQS VSLMTLTLKD
     PSPKTRACAL QVLSAILEGS KQFLSVAEDT SDHKRAFTPF SVTIASSIRE LHRCLLLALV
     AESSSQTLTQ IIKCLANLVS NAPYNRLKLS LLTKVWNHIK PYIRHKDVNV RVSSLTLLGA
     VVSTHAPLPE VQLLLQQPCS SGRSSSSATP HLSTPDGWKA LPAGPSLEEA SLSSPKGTAE
     PCWLIRLCIS TVVLPKEDSC SGSDAGSALG STYEPSPMRL EALQVLAHLA RGYFSMAQLY
     LMELGEVICK CMCEANPSIQ LHGVKLLEEL GTGLIQQYKP DSSTAPEQRV PVHMVAMFWT
     AMLNGPLPRA LQSTEHPTLQ ASACDALSSI LPEAFSSLPN DKQILCITML LGLNDSKNHL
     VKAATSRALG VYVLFPCLRQ DVIFVADTAN AILMSLQDKS LNVRAKAAWS LGNLTDTLIV
     NMDTPDPSFQ DEFSGLLLLK MLQSAIQAST DKDKVKSNAV RALGNLLHFL QPSHIERPRF
     AEIIEESIQA LISTVVNEAA MKVRWNACYA MGNVFKNPAL PLGTAPWTSQ AYKALTSVVM
     SCKNFKVRIR SAAALSVPGR RAQYGSLEQF SQIWSALVTA LQRSEDTTDF LEFKYCASLR
     THVCQALLHL LGLASASDLP CIQETLTVNG DMIRSYILQF LKSGAGGDDP GAVHSPQERN
     QMVRVALRHI HSVQALAGDT AKGAIVGFLE DILTVHCDSS GERAVLRGSL DQ