ID   HEAT6_XENLA             Reviewed;        1174 AA.
AC   Q7ZY56;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=HEAT repeat-containing protein 6;
GN   Name=heatr6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC043967; AAH43967.1; -; mRNA.
DR   RefSeq; NP_001079513.1; NM_001086044.1.
DR   AlphaFoldDB; Q7ZY56; -.
DR   MaxQB; Q7ZY56; -.
DR   DNASU; 379200; -.
DR   GeneID; 379200; -.
DR   KEGG; xla:379200; -.
DR   CTD; 379200; -.
DR   Xenbase; XB-GENE-5772487; heatr6.S.
DR   OMA; KPYICHK; -.
DR   OrthoDB; 106835at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 379200; Expressed in oocyte and 19 other tissues.
DR   Gene3D; 1.25.10.10; -; 4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR025283; DUF4042.
DR   InterPro; IPR000357; HEAT.
DR   Pfam; PF13251; DUF4042; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1174
FT                   /note="HEAT repeat-containing protein 6"
FT                   /id="PRO_0000337178"
FT   REPEAT          168..207
FT                   /note="HEAT 1"
FT   REPEAT          460..498
FT                   /note="HEAT 2"
FT   REPEAT          523..560
FT                   /note="HEAT 3"
FT   REPEAT          566..603
FT                   /note="HEAT 4"
FT   REGION          304..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          619..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..647
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1174 AA;  130049 MW;  413FEF48DC195CDD CRC64;
     MAAQEDRLDS FGMQHGILLS SSPSLQPPYN HQEYAWDFQR YLNKLQSLRP SDSESFRTEI
     NLLLDQLISQ DYTPGVTGIG QEEVCAILVQ ACRLVQHNQE HLVSKVCQLV HYLLNRLQVI
     VDEQNLDFLL AFSISALKQC SSWTHADVLH ALAALVYNNG SKCQKYLNEL LGPTGILVNL
     CDPSQPDPEL WREAIHCMAN LCLGVPGHPY LDEPYRMTCF KNFLTVLQTP KPNIVDDIAV
     CTLLQNALKG IQSLLNGSKI KLLETGQLGS LLAVLKKYMF HGLPGLSIEM PTVLYPTPLA
     QYDGRSPTKP EQPEAAVNQP TWSKKKRKAG KQKKGHQGEE SKEELKNEIG AEINKDLEKM
     KLCSGEAQHS LYLGPQKSPL DPHQGQVGKD HFSPQVQRYK KINSSDSEYS DAEGSLQNKI
     RSFQAKVRQG ALSCFLSTIK SIEKKVLYGY WSAFVPDISG IGSPQSVSLM TIALKDSSPK
     TRACALQVLS AILDGSKQFL SVADDASDHK RAFTPLSVTL ASSIRELHRC LLLAIVAESS
     AQTLTQIIKC LANLVSNAPY HRLKPGLLTR VWNQIKPYIR NKDVNVRVSS LTLLGAIVSA
     QVSLPEVQLL LQQPLYSLSQ NSGSATPSDP ESNRKESMLE GGKKNGLHSE HSQSCWLIRL
     CITLVVEPRE DSYSDSEPSS TPAVMYEPSP VRLEALQVLA CLVKGCFNMA QSYLIELGEV
     ACKCMQETDA SIQLHGAKLL EELGTGIVQQ QKPDSIVPIN LMVPINQAVT FWNMILNGPL
     PAALQNEQHP TLQTSACDAL SSVLPEAFSN LPNDRQILCI TLLLGLNHSE NPLVKAAAAR
     ALGVYILFPC LRQDVMFVAD TANAILMCLS DRSPNVRAKA AWSLGNLTDS LIVNMEAMGQ
     SFQEEFSDML LLKMLWAATE ASKDKDKVKS NAVRALGNLL HFLQPYHIVK PRFCESIECA
     IQALVSTVLG DGTMKVKWNA CYALGNVFKN TALPLGKATW TAAAYNALTT VVKACKNFKV
     RIKSAMALSI PFSREQYGST EQYCDIWNAL VTALQKSEDT EDFLEFKYSA SLREQICQAL
     IHLLSLASQE DLPRIRKTLL EKGDSIRNYV LHYVKSEVQG DESQREHQDR GKMLQRAIEH
     IRGFEELPGS NKGLIEVAYF EAILVSCDKE MEAL