ID   HEBP1_BOVIN             Reviewed;         191 AA.
AC   Q148C9;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Heme-binding protein 1;
GN   Name=HEBP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind free porphyrinogens that may be present in the cell
CC       and thus facilitate removal of these potentially toxic compound. Binds
CC       with a high affinity to one molecule of heme or porphyrins. It binds
CC       metalloporphyrins, free porphyrins and N-methylprotoporphyrin with
CC       similar affinities (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Forms a distorted beta-barrel structure, with two helices that
CC       are packed against the outer surface of the barrel. Porphyrins are
CC       expected to bind to a hydrophobic patch on the outer surface of the
CC       beta-barrel structure (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEBP family. {ECO:0000305}.
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DR   EMBL; BC118459; AAI18460.1; -; mRNA.
DR   RefSeq; NP_001069453.1; NM_001075985.2.
DR   AlphaFoldDB; Q148C9; -.
DR   SMR; Q148C9; -.
DR   STRING; 9913.ENSBTAP00000007711; -.
DR   PaxDb; Q148C9; -.
DR   PeptideAtlas; Q148C9; -.
DR   PRIDE; Q148C9; -.
DR   Ensembl; ENSBTAT00000007711; ENSBTAP00000007711; ENSBTAG00000005868.
DR   GeneID; 533227; -.
DR   KEGG; bta:533227; -.
DR   CTD; 50865; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005868; -.
DR   eggNOG; ENOG502RYZW; Eukaryota.
DR   GeneTree; ENSGT00940000160320; -.
DR   HOGENOM; CLU_068699_3_0_1; -.
DR   InParanoid; Q148C9; -.
DR   OMA; MLGMIRN; -.
DR   OrthoDB; 1611913at2759; -.
DR   TreeFam; TF328887; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000005868; Expressed in cortex of kidney and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR   Gene3D; 3.20.80.10; -; 1.
DR   InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR   InterPro; IPR006917; SOUL_haem-bd.
DR   PANTHER; PTHR11220; PTHR11220; 1.
DR   Pfam; PF04832; SOUL; 1.
DR   SUPFAM; SSF55136; SSF55136; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..191
FT                   /note="Heme-binding protein 1"
FT                   /id="PRO_0000286548"
SQ   SEQUENCE   191 AA;  21230 MW;  E95387A88BB322BF CRC64;
     MLGMIKNSLF GSVETWPWQV LSKGSKGDVF YEERACEGGK FATVEVTDKP VDEALREAMP
     KVMKYVGGSN DKGLGMGMTV PISFAVFPSD DGDLQKKLKV WFRIPNKFQS DPPAPSDDSI
     KIEDREGITV YSTQFGGYAK AADYAAQAAQ LRSALESTAK YQTDFYFCTG YDPPMKPYGR
     RNEVWLVKSS E