ID   HEBP1_CHICK             Reviewed;         189 AA.
AC   Q5ZMB2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Heme-binding protein 1;
GN   Name=HEBP1; ORFNames=RCJMB04_2k3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May bind free porphyrinogens that may be present in the cell
CC       and thus facilitate removal of these potentially toxic compound. Binds
CC       with a high affinity to one molecule of heme or porphyrins. It binds
CC       metalloporphyrins, free porphyrins and N-methylprotoporphyrin with
CC       similar affinities (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Forms a distorted beta-barrel structure, with two helices that
CC       are packed against the outer surface of the barrel. Porphyrins are
CC       expected to bind to a hydrophobic patch on the outer surface of the
CC       beta-barrel structure (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEBP family. {ECO:0000305}.
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DR   EMBL; AJ719472; CAG31131.1; -; mRNA.
DR   RefSeq; NP_001025925.1; NM_001030754.1.
DR   AlphaFoldDB; Q5ZMB2; -.
DR   SMR; Q5ZMB2; -.
DR   BioGRID; 679235; 1.
DR   IntAct; Q5ZMB2; 1.
DR   STRING; 9031.ENSGALP00000019231; -.
DR   PaxDb; Q5ZMB2; -.
DR   GeneID; 417961; -.
DR   KEGG; gga:417961; -.
DR   CTD; 50865; -.
DR   VEuPathDB; HostDB:geneid_417961; -.
DR   eggNOG; ENOG502RYZW; Eukaryota.
DR   InParanoid; Q5ZMB2; -.
DR   OrthoDB; 1611913at2759; -.
DR   PhylomeDB; Q5ZMB2; -.
DR   PRO; PR:Q5ZMB2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR   Gene3D; 3.20.80.10; -; 1.
DR   InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR   InterPro; IPR006917; SOUL_haem-bd.
DR   PANTHER; PTHR11220; PTHR11220; 1.
DR   Pfam; PF04832; SOUL; 1.
DR   SUPFAM; SSF55136; SSF55136; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..189
FT                   /note="Heme-binding protein 1"
FT                   /id="PRO_0000286549"
SQ   SEQUENCE   189 AA;  21105 MW;  B57A4675044BD6BF CRC64;
     MLGMIKNSLL STVETWPYRV LSKGEKEQLS YEERECEGGQ FAVVEVTGKP FDEASKEAAL
     KLLKYVGGSN DKGAGMGMTA PVSITAFPAE DGSLQQKVKV YLRIPNQFQA SPPCPSDESI
     KIEERQGMTI YSTQFGGYAK EVDYVNYAAK LKTALGSEAA YRKDFYFCNG YDPPMKPYGR
     RNEVWFVKE