ID   ANF_PELRI               Reviewed;          30 AA.
AC   P09196;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Natriuretic peptides A;
DE   Contains:
DE     RecName: Full=Atrial natriuretic factor;
DE              Short=ANF;
DE     AltName: Full=Atrial natriuretic peptide;
DE              Short=ANP;
DE   Flags: Precursor;
OS   Pelophylax ridibundus (Marsh frog) (Rana ridibunda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=8406;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Heart atrium;
RX   PubMed=2971573; DOI=10.1016/0014-5793(88)80501-5;
RA   Lazure C., Ong H., McNicoll N., Netchitailo P., Chretien M., de Lean A.,
RA   Vaudry H.;
RT   "The amino acid sequences of frog heart atrial natriuretic-like peptide and
RT   mammalian ANF are closely related.";
RL   FEBS Lett. 238:300-306(1988).
CC   -!- FUNCTION: Hormone playing a key role in cardiovascular homeostasis
CC       through regulation of natriuresis, diuresis, and vasodilation. Has a
CC       cGMP-stimulating activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Cleaved upon secretion to produce the functional hormone.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S01657; S01657.
DR   AlphaFoldDB; P09196; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted; Vasoactive.
FT   PROPEP          1..3
FT                   /id="PRO_0000391786"
FT   PEPTIDE         4..30
FT                   /note="Atrial natriuretic factor"
FT                   /id="PRO_0000391787"
FT   SITE            3..4
FT                   /note="Cleavage"
FT                   /evidence="ECO:0000250"
FT   DISULFID        11..27
SQ   SEQUENCE   30 AA;  3263 MW;  175A946321C27DA0 CRC64;
     APRSMRRSSD CFGSRIDRIG AQSGMGCGRF