HEBP1_XENLA
ID HEBP1_XENLA Reviewed; 190 AA.
AC Q6NU05;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Heme-binding protein 1;
GN Name=hebp1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May bind free porphyrinogens that may be present in the cell
CC and thus facilitate removal of these potentially toxic compound. Binds
CC with a high affinity to one molecule of heme or porphyrins. It binds
CC metalloporphyrins, free porphyrins and N-methylprotoporphyrin with
CC similar affinities (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: Forms a distorted beta-barrel structure, with two helices that
CC are packed against the outer surface of the barrel. Porphyrins are
CC expected to bind to a hydrophobic patch on the outer surface of the
CC beta-barrel structure (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HEBP family. {ECO:0000305}.
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DR EMBL; BC068797; AAH68797.1; -; mRNA.
DR RefSeq; NP_001084668.1; NM_001091199.1.
DR AlphaFoldDB; Q6NU05; -.
DR SMR; Q6NU05; -.
DR MaxQB; Q6NU05; -.
DR GeneID; 414628; -.
DR KEGG; xla:414628; -.
DR CTD; 414628; -.
DR Xenbase; XB-GENE-1002296; hebp1.L.
DR OrthoDB; 1611913at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 414628; Expressed in liver and 20 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR Gene3D; 3.20.80.10; -; 1.
DR InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR InterPro; IPR006917; SOUL_haem-bd.
DR PANTHER; PTHR11220; PTHR11220; 1.
DR Pfam; PF04832; SOUL; 1.
DR SUPFAM; SSF55136; SSF55136; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..190
FT /note="Heme-binding protein 1"
FT /id="PRO_0000286550"
SQ SEQUENCE 190 AA; 21073 MW; 997C0BC7AC4E6B38 CRC64;
MFGMIKNSLL GGVENNEGKL VSKGEKDGVA FEEREYEGGK FISTEVSGKP FDEASKEGVL
RLLKYVGGSN NKSAGMGMTS PVIINSYPSE NDTLQPNVKV LLRIPSQYQA DPPVPTDNTI
QIEDRESVTL YSTQFGGYAK EADYVSHAAK LRSCLGPDIS YHSDYYMCCG YDPPMKPYGR
RNEVWFIKNN