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HEBP1_XENLA
ID   HEBP1_XENLA             Reviewed;         190 AA.
AC   Q6NU05;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Heme-binding protein 1;
GN   Name=hebp1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind free porphyrinogens that may be present in the cell
CC       and thus facilitate removal of these potentially toxic compound. Binds
CC       with a high affinity to one molecule of heme or porphyrins. It binds
CC       metalloporphyrins, free porphyrins and N-methylprotoporphyrin with
CC       similar affinities (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Forms a distorted beta-barrel structure, with two helices that
CC       are packed against the outer surface of the barrel. Porphyrins are
CC       expected to bind to a hydrophobic patch on the outer surface of the
CC       beta-barrel structure (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEBP family. {ECO:0000305}.
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DR   EMBL; BC068797; AAH68797.1; -; mRNA.
DR   RefSeq; NP_001084668.1; NM_001091199.1.
DR   AlphaFoldDB; Q6NU05; -.
DR   SMR; Q6NU05; -.
DR   MaxQB; Q6NU05; -.
DR   GeneID; 414628; -.
DR   KEGG; xla:414628; -.
DR   CTD; 414628; -.
DR   Xenbase; XB-GENE-1002296; hebp1.L.
DR   OrthoDB; 1611913at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 414628; Expressed in liver and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR   Gene3D; 3.20.80.10; -; 1.
DR   InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR   InterPro; IPR006917; SOUL_haem-bd.
DR   PANTHER; PTHR11220; PTHR11220; 1.
DR   Pfam; PF04832; SOUL; 1.
DR   SUPFAM; SSF55136; SSF55136; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Heme-binding protein 1"
FT                   /id="PRO_0000286550"
SQ   SEQUENCE   190 AA;  21073 MW;  997C0BC7AC4E6B38 CRC64;
     MFGMIKNSLL GGVENNEGKL VSKGEKDGVA FEEREYEGGK FISTEVSGKP FDEASKEGVL
     RLLKYVGGSN NKSAGMGMTS PVIINSYPSE NDTLQPNVKV LLRIPSQYQA DPPVPTDNTI
     QIEDRESVTL YSTQFGGYAK EADYVSHAAK LRSCLGPDIS YHSDYYMCCG YDPPMKPYGR
     RNEVWFIKNN
 
 
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