ID   HEBP1_XENTR             Reviewed;         190 AA.
AC   Q6DJ66;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Heme-binding protein 1;
GN   Name=hebp1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind free porphyrinogens that may be present in the cell
CC       and thus facilitate removal of these potentially toxic compound. Binds
CC       with a high affinity to one molecule of heme or porphyrins. It binds
CC       metalloporphyrins, free porphyrins and N-methylprotoporphyrin with
CC       similar affinities (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Forms a distorted beta-barrel structure, with two helices that
CC       are packed against the outer surface of the barrel. Porphyrins are
CC       expected to bind to a hydrophobic patch on the outer surface of the
CC       beta-barrel structure (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEBP family. {ECO:0000305}.
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DR   EMBL; BC075317; AAH75317.1; -; mRNA.
DR   RefSeq; NP_001004901.1; NM_001004901.1.
DR   AlphaFoldDB; Q6DJ66; -.
DR   SMR; Q6DJ66; -.
DR   STRING; 8364.ENSXETP00000057031; -.
DR   PaxDb; Q6DJ66; -.
DR   DNASU; 448253; -.
DR   Ensembl; ENSXETT00000057031; ENSXETP00000057031; ENSXETG00000027311.
DR   GeneID; 448253; -.
DR   KEGG; xtr:448253; -.
DR   CTD; 50865; -.
DR   Xenbase; XB-GENE-1002291; hebp1.
DR   eggNOG; ENOG502RYZW; Eukaryota.
DR   HOGENOM; CLU_068699_3_0_1; -.
DR   InParanoid; Q6DJ66; -.
DR   OMA; NDKXQFG; -.
DR   OrthoDB; 1611913at2759; -.
DR   PhylomeDB; Q6DJ66; -.
DR   TreeFam; TF328887; -.
DR   Reactome; R-XTR-418594; G alpha (i) signalling events.
DR   Reactome; R-XTR-444473; Formyl peptide receptors bind formyl peptides and many other ligands.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027311; Expressed in liver and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR   Gene3D; 3.20.80.10; -; 1.
DR   InterPro; IPR011256; Reg_factor_effector_dom_sf.
DR   InterPro; IPR006917; SOUL_haem-bd.
DR   PANTHER; PTHR11220; PTHR11220; 1.
DR   Pfam; PF04832; SOUL; 1.
DR   SUPFAM; SSF55136; SSF55136; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Heme-binding protein 1"
FT                   /id="PRO_0000286551"
SQ   SEQUENCE   190 AA;  21200 MW;  878EA0AB584DBF51 CRC64;
     MFGMIKNSLF GGVENNEGKL VSKGEKDGVA FEEREYEGGK FVSTEVSGKP FDEASKEAVL
     RLLKYVGGSN QKYAGMGMTS PVVITSYPAE NETLQPNVKV LLRIPSQYQA DPPVPTDDTI
     HIEDRESVTF YSTQFGGYAK EADYVSHAAK LRSCLGPDIS YHTDHYMCCG YDPPMKPYGR
     RNEVWFIKNN