HEC1_ARATH
ID HEC1_ARATH Reviewed; 241 AA.
AC Q9FHA7;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Transcription factor HEC1;
DE AltName: Full=Basic helix-loop-helix protein 88;
DE Short=AtbHLH88;
DE Short=bHLH 88;
DE AltName: Full=Protein HECATE 1;
DE AltName: Full=Transcription factor EN 118;
DE AltName: Full=bHLH transcription factor bHLH088;
GN Name=HEC1; Synonyms=BHLH88, EN118; OrderedLocusNames=At5g67060;
GN ORFNames=K21H1.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia; TISSUE=Flower;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH SPT, INDUCTION BY
RP ARF3/ETT, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=17855426; DOI=10.1242/dev.011510;
RA Gremski K., Ditta G., Yanofsky M.F.;
RT "The HECATE genes regulate female reproductive tract development in
RT Arabidopsis thaliana.";
RL Development 134:3593-3601(2007).
RN [8]
RP INTERACTION WITH BZIP30.
RX PubMed=27402171; DOI=10.1111/tpj.13264;
RA Lozano-Sotomayor P., Chavez Montes R.A., Silvestre-Vano M.,
RA Herrera-Ubaldo H., Greco R., Pablo-Villa J., Galliani B.M.,
RA Diaz-Ramirez D., Weemen M., Boutilier K., Pereira A., Colombo L.,
RA Madueno F., Marsch-Martinez N., de Folter S.;
RT "Altered expression of the bZIP transcription factor DRINK ME affects
RT growth and reproductive development in Arabidopsis thaliana.";
RL Plant J. 88:437-451(2016).
CC -!- FUNCTION: Required for the female reproductive tract development and
CC fertility. {ECO:0000269|PubMed:17855426}.
CC -!- SUBUNIT: Homodimer (Probable). Interacts with SPT. Interacts with
CC BZIP30 (PubMed:27402171). {ECO:0000269|PubMed:17855426,
CC ECO:0000269|PubMed:27402171, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Flowers, especially in gynoecium.
CC {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:17855426}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing septum, transmitting
CC tract and stigma. {ECO:0000269|PubMed:17855426}.
CC -!- INDUCTION: Negatively regulated by ARF3/ETT in the abaxial gynoecium.
CC {ECO:0000269|PubMed:17855426}.
CC -!- DISRUPTION PHENOTYPE: Impaired pollen tube growth.
CC {ECO:0000269|PubMed:17855426}.
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DR EMBL; AF488618; AAM10961.1; -; mRNA.
DR EMBL; AB020742; BAB10940.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98296.1; -; Genomic_DNA.
DR EMBL; AK228927; BAF00816.1; -; mRNA.
DR RefSeq; NP_201507.1; NM_126106.3.
DR AlphaFoldDB; Q9FHA7; -.
DR SMR; Q9FHA7; -.
DR BioGRID; 22083; 7.
DR IntAct; Q9FHA7; 6.
DR STRING; 3702.AT5G67060.1; -.
DR PaxDb; Q9FHA7; -.
DR PRIDE; Q9FHA7; -.
DR EnsemblPlants; AT5G67060.1; AT5G67060.1; AT5G67060.
DR GeneID; 836841; -.
DR Gramene; AT5G67060.1; AT5G67060.1; AT5G67060.
DR KEGG; ath:AT5G67060; -.
DR Araport; AT5G67060; -.
DR TAIR; locus:2155543; AT5G67060.
DR eggNOG; ENOG502RXGQ; Eukaryota.
DR HOGENOM; CLU_068572_1_0_1; -.
DR InParanoid; Q9FHA7; -.
DR OMA; TIGTHQM; -.
DR OrthoDB; 1511639at2759; -.
DR PhylomeDB; Q9FHA7; -.
DR PRO; PR:Q9FHA7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FHA7; baseline and differential.
DR Genevisible; Q9FHA7; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0048462; P:carpel formation; IMP:TAIR.
DR GO; GO:0048467; P:gynoecium development; IGI:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IPI:TAIR.
DR GO; GO:2000012; P:regulation of auxin polar transport; IGI:TAIR.
DR GO; GO:0010468; P:regulation of gene expression; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009266; P:response to temperature stimulus; IEP:TAIR.
DR GO; GO:0010500; P:transmitting tissue development; IGI:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR045843; IND-like.
DR PANTHER; PTHR45914; PTHR45914; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..241
FT /note="Transcription factor HEC1"
FT /id="PRO_0000358845"
FT DOMAIN 128..177
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 241 AA; 26230 MW; C4C126B6C98EEB23 CRC64;
MDSDIMNMMM HQMEKLPEFC NPNSSFFSPD HNNTYPFLFN STHYQSDHSM TNEPGFRYGS
GLLTNPSSIS PNTAYSSVFL DKRNNSNNNN NGTNMAAMRE MIFRIAVMQP IHIDPEAVKP
PKRRNVRISK DPQSVAARHR RERISERIRI LQRLVPGGTK MDTASMLDEA IHYVKFLKKQ
VQSLEEQAVV TGGGGGGGGR VLIGGGGMTA ASGGGGGGGV VMKGCGTVGT HQMVGNAQIL
R
