HEC2_ARATH
ID HEC2_ARATH Reviewed; 231 AA.
AC Q9SND4; Q67ZU7;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Transcription factor HEC2;
DE AltName: Full=Basic helix-loop-helix protein 37;
DE Short=AtbHLH37;
DE Short=bHLH 37;
DE AltName: Full=Protein HECATE 2;
DE AltName: Full=Transcription factor EN 117;
DE AltName: Full=bHLH transcription factor bHLH037;
GN Name=HEC2; Synonyms=BHLH37, EN117; OrderedLocusNames=At3g50330;
GN ORFNames=F11C1.170;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH SPT, INDUCTION BY ETT,
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=17855426; DOI=10.1242/dev.011510;
RA Gremski K., Ditta G., Yanofsky M.F.;
RT "The HECATE genes regulate female reproductive tract development in
RT Arabidopsis thaliana.";
RL Development 134:3593-3601(2007).
CC -!- FUNCTION: Required for the female reproductive tract development and
CC fertility. {ECO:0000269|PubMed:17855426}.
CC -!- SUBUNIT: Homodimer (Probable). Interacts with SPT.
CC {ECO:0000269|PubMed:17855426, ECO:0000305}.
CC -!- INTERACTION:
CC Q9SND4; Q9LQT8: GAI; NbExp=3; IntAct=EBI-1536720, EBI-963606;
CC Q9SND4; O81313: IND; NbExp=3; IntAct=EBI-1536720, EBI-4446992;
CC Q9SND4; Q9SLH3: RGA; NbExp=4; IntAct=EBI-1536720, EBI-963624;
CC Q9SND4; Q8GXW1: RGL2; NbExp=3; IntAct=EBI-1536720, EBI-963665;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Gynoecium. {ECO:0000269|PubMed:17855426}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing septum, transmitting
CC tract and stigma. {ECO:0000269|PubMed:17855426}.
CC -!- INDUCTION: Negatively regulated by ARF3/ETT in the abaxial gynoecium.
CC {ECO:0000269|PubMed:17855426}.
CC -!- DISRUPTION PHENOTYPE: Impaired pollen tube growth.
CC {ECO:0000269|PubMed:17855426}.
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DR EMBL; AL132976; CAB62312.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78653.1; -; Genomic_DNA.
DR EMBL; BT010607; AAQ89629.1; -; mRNA.
DR EMBL; AK175679; BAD43442.1; -; mRNA.
DR EMBL; AK175912; BAD43675.1; -; mRNA.
DR EMBL; AK176020; BAD43783.1; -; mRNA.
DR PIR; T45579; T45579.
DR RefSeq; NP_190602.1; NM_114893.3.
DR AlphaFoldDB; Q9SND4; -.
DR SMR; Q9SND4; -.
DR BioGRID; 9513; 15.
DR IntAct; Q9SND4; 15.
DR STRING; 3702.AT3G50330.1; -.
DR PaxDb; Q9SND4; -.
DR PRIDE; Q9SND4; -.
DR EnsemblPlants; AT3G50330.1; AT3G50330.1; AT3G50330.
DR GeneID; 824195; -.
DR Gramene; AT3G50330.1; AT3G50330.1; AT3G50330.
DR KEGG; ath:AT3G50330; -.
DR Araport; AT3G50330; -.
DR TAIR; locus:2074865; AT3G50330.
DR eggNOG; ENOG502RXGQ; Eukaryota.
DR HOGENOM; CLU_068572_1_0_1; -.
DR InParanoid; Q9SND4; -.
DR OMA; CSDNANM; -.
DR OrthoDB; 1511639at2759; -.
DR PhylomeDB; Q9SND4; -.
DR PRO; PR:Q9SND4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SND4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0048462; P:carpel formation; IMP:TAIR.
DR GO; GO:0048467; P:gynoecium development; IGI:TAIR.
DR GO; GO:0080126; P:ovary septum development; IGI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009266; P:response to temperature stimulus; IEP:TAIR.
DR GO; GO:0010500; P:transmitting tissue development; IGI:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR045843; IND-like.
DR PANTHER; PTHR45914; PTHR45914; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..231
FT /note="Transcription factor HEC2"
FT /id="PRO_0000358846"
FT DOMAIN 125..174
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT CONFLICT 78
FT /note="S -> P (in Ref. 4; BAD43783)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 231 AA; 25684 MW; 9BF25F6815E27407 CRC64;
MDNSDILMNM MMQQMEKLPE HFSNSNPNPN PHNIMMLSES NTHPFFFNPT HSHLPFDQTM
PHHQPGLNFR YAPSPSSSLP EKRGGCSDNA NMAAMREMIF RIAVMQPIHI DPESVKPPKR
KNVRISKDPQ SVAARHRRER ISERIRILQR LVPGGTKMDT ASMLDEAIHY VKFLKKQVQS
LEEHAVVNGG GMTAVAGGAL AGTVGGGYGG KGCGIMRSDH HQMLGNAQIL R
