HECD4_HUMAN
ID HECD4_HUMAN Reviewed; 3996 AA.
AC Q9Y4D8; L8B0P6; Q3MJD5; Q6P0A0; Q7L530; Q8NB70; Q8WU73; Q96NT9; Q9NZS4;
AC Q9UFT6;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 5.
DT 25-MAY-2022, entry version 147.
DE RecName: Full=Probable E3 ubiquitin-protein ligase HECTD4;
DE EC=2.3.2.26;
DE AltName: Full=HECT domain-containing protein 4;
DE AltName: Full=HECT-type E3 ubiquitin transferase HECTD4;
GN Name=HECTD4; Synonyms=C12orf51, KIAA0614;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
RX PubMed=23261826; DOI=10.1016/j.gene.2012.11.076;
RA Ishida H., Yagi T., Tanaka M., Tokuda Y., Kamoi K., Hongo F., Kawauchi A.,
RA Nakano M., Miki T., Tashiro K.;
RT "Identification of a novel gene by whole human genome tiling array.";
RL Gene 516:33-38(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-801 (ISOFORM 4), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 212-3996 (ISOFORM 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 3257-3996 (ISOFORM 1).
RC TISSUE=Brain, Eye, Lung, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 184-3996 (ISOFORM 3), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1835-3996 (ISOFORM 2).
RC TISSUE=Brain, and Glial tumor;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 995-3996 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9734811; DOI=10.1093/dnares/5.3.169;
RA Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H.,
RA Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. X. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:169-176(1998).
RN [6]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2620-3996 (ISOFORM 1).
RC TISSUE=Placenta;
RA Govindan M.V., Warriar N.;
RT "Human GR AF-1 specific protein phosphatase.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3881-3996 (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2080, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an
CC E2 ubiquitin-conjugating enzyme in the form of a thioester and then
CC directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- INTERACTION:
CC Q9Y4D8; P63104: YWHAZ; NbExp=2; IntAct=EBI-7195436, EBI-347088;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q9Y4D8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y4D8-2; Sequence=VSP_034529, VSP_034530;
CC Name=3;
CC IsoId=Q9Y4D8-3; Sequence=VSP_039452, VSP_039453, VSP_039454;
CC Name=4;
CC IsoId=Q9Y4D8-4; Sequence=VSP_039451, VSP_039452;
CC Name=5; Synonyms=POTAGE;
CC IsoId=Q9Y4D8-5; Sequence=VSP_047465, VSP_047466, VSP_039452,
CC VSP_039453, VSP_039454;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF36539.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC Sequence=AAH65706.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH65706.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAI01483.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA31589.3; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC Sequence=BAC03671.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB777655; BAM76724.1; -; mRNA.
DR EMBL; AC073575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006270; AAH06270.2; -; mRNA.
DR EMBL; BC021144; AAH21144.1; -; mRNA.
DR EMBL; BC065706; AAH65706.1; ALT_SEQ; mRNA.
DR EMBL; BC101482; AAI01483.1; ALT_INIT; mRNA.
DR EMBL; AK054654; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK091473; BAC03671.1; ALT_INIT; mRNA.
DR EMBL; AB014514; BAA31589.3; ALT_SEQ; mRNA.
DR EMBL; AF174498; AAF36539.1; ALT_SEQ; mRNA.
DR EMBL; AL117469; CAB55944.1; -; mRNA.
DR PIR; T00390; T00390.
DR IntAct; Q9Y4D8; 16.
DR MINT; Q9Y4D8; -.
DR STRING; 9606.ENSP00000449784; -.
DR iPTMnet; Q9Y4D8; -.
DR PhosphoSitePlus; Q9Y4D8; -.
DR BioMuta; HECTD4; -.
DR DMDM; 300669718; -.
DR EPD; Q9Y4D8; -.
DR jPOST; Q9Y4D8; -.
DR MassIVE; Q9Y4D8; -.
DR MaxQB; Q9Y4D8; -.
DR PaxDb; Q9Y4D8; -.
DR PeptideAtlas; Q9Y4D8; -.
DR PRIDE; Q9Y4D8; -.
DR ProteomicsDB; 86170; -. [Q9Y4D8-1]
DR ProteomicsDB; 86171; -. [Q9Y4D8-2]
DR ProteomicsDB; 86172; -. [Q9Y4D8-3]
DR ProteomicsDB; 86173; -. [Q9Y4D8-4]
DR GeneCards; HECTD4; -.
DR HGNC; HGNC:26611; HECTD4.
DR neXtProt; NX_Q9Y4D8; -.
DR eggNOG; KOG1426; Eukaryota.
DR InParanoid; Q9Y4D8; -.
DR PhylomeDB; Q9Y4D8; -.
DR PathwayCommons; Q9Y4D8; -.
DR SignaLink; Q9Y4D8; -.
DR SIGNOR; Q9Y4D8; -.
DR UniPathway; UPA00143; -.
DR ChiTaRS; HECTD4; human.
DR Pharos; Q9Y4D8; Tbio.
DR PRO; PR:Q9Y4D8; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9Y4D8; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0042593; P:glucose homeostasis; IMP:UniProtKB.
DR GO; GO:0006006; P:glucose metabolic process; IMP:UniProtKB.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd13735; SPRY_HECT_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR043366; HECTD4.
DR InterPro; IPR035781; SPRY_HECTD4.
DR PANTHER; PTHR46435; PTHR46435; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; SSF56204; 1.
DR PROSITE; PS50237; HECT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix; Ubl conjugation pathway.
FT CHAIN 1..3996
FT /note="Probable E3 ubiquitin-protein ligase HECTD4"
FT /id="PRO_0000342681"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 3627..3996
FT /note="HECT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00104"
FT REGION 1494..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1616..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2219..2245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2859..2919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3017..3053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3327..3403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1494..1509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1510..1525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1616..1630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2859..2887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3017..3034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3327..3344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3373..3403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 3964
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00104"
FT MOD_RES 2080
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1
FT /note="M -> MGSSAAAAAAAAAAADSAQWLSVKEETIFLHDGLIRVTDLAELPSEI
FT LGAPEAADTDLEILTFETKNPSELAERLRSVCGNQSNAYARLLEYRLNALRGLWNAQRQ
FT LALEEQHERESSGDEETLALLKRQGLLQQPEQAPFTSRMGLLLVFPLIQSQSRTDPSLC
FT NITAEVLLNCLRDCQPLSLTKEPADCLNGIETLLCSWLEETSDTGRHIPHKQKENAAAA
FT LVALACARGSLKTFVHTVHLLQKQTDLGSLPVADVLYRLLLLEGGPGSPSCLLGGKHIV
FT SWGYEDMLPAPDSNTGSSSENKDADLGRCLTADGLYLYTTNSVGRGVSKLGSGLHGTLR
FT GFVYCRNEELEPGWVAFGSGSLLHRPVSFDNKPHSLFQVIDQNTLQVCQVVPM (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:23261826"
FT /id="VSP_047465"
FT VAR_SEQ 169
FT /note="R -> ILASSLVYNISDGQFTSRADLIDAAGSSLGRGALVPGLG (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:23261826"
FT /id="VSP_047466"
FT VAR_SEQ 483..484
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039451"
FT VAR_SEQ 717..726
FT /note="Missing (in isoform 3, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:23261826"
FT /id="VSP_039452"
FT VAR_SEQ 896..899
FT /note="EVIQ -> YVAV (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:23261826"
FT /id="VSP_039453"
FT VAR_SEQ 900..3996
FT /note="Missing (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:23261826"
FT /id="VSP_039454"
FT VAR_SEQ 2382..2386
FT /note="NELVQ -> SEQPF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034529"
FT VAR_SEQ 2387..3996
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034530"
FT CONFLICT 170
FT /note="A -> G (in Ref. 3; AAH65706)"
FT /evidence="ECO:0000305"
FT CONFLICT 681
FT /note="Y -> C (in Ref. 4; BAC03671)"
FT /evidence="ECO:0000305"
FT CONFLICT 801
FT /note="K -> E (in Ref. 3; AAH65706)"
FT /evidence="ECO:0000305"
FT CONFLICT 2019
FT /note="T -> I (in Ref. 4; AK054654)"
FT /evidence="ECO:0000305"
FT CONFLICT 2702
FT /note="E -> G (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 2867
FT /note="S -> T (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 2896..2897
FT /note="KR -> NA (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 2902
FT /note="S -> C (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3153
FT /note="S -> P (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3182
FT /note="R -> Q (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3191
FT /note="L -> F (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3419..3420
FT /note="DR -> YQ (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3665
FT /note="S -> A (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3723
FT /note="P -> T (in Ref. 3; AAH06270)"
FT /evidence="ECO:0000305"
FT CONFLICT 3726
FT /note="W -> R (in Ref. 3; AAH06270)"
FT /evidence="ECO:0000305"
FT CONFLICT 3732..3733
FT /note="EP -> DA (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3798
FT /note="E -> R (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3830
FT /note="E -> A (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
FT CONFLICT 3985
FT /note="C -> G (in Ref. 7; AAF36539)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3996 AA; 439344 MW; 5F091CA1EDD207D4 CRC64;
MPANHLPIGS TMSTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL VVENGVFVAN
PLQERTILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA LTGSTISNTL KEDQAANTSC
GLPLKMLRKT PIYTCGTYLV MLVPPPGGSG SSATRSLFGG TSGLSSLKRA CYDTVNNMLW
TCSNDYIDQW CNPGNQAFHY VCQRLGVSHI ITEPKEEAIT TNEVINQLLH HVGAMCIHQL
NLLATNPNLP ITSVLGKQHP IEAHHLSSIC DIMEKAMVNG DTCIIRCILV VFQVVFKFFF
SPQTERNRDI IRRSGLLLWQ LLMAPKDQIC PEIQKEVCLA ISSGLNILYP GETEINNLLK
LVLTEGERNS GLSQLRDVIL TNLAEQLQNN RFGSDEDDHY RLNDELLHYI LKIVVRESCI
LITKCQTVSK DDFQKLLSTV PAASSCLRYL MAVQNHLLSN TILIKPDEND DSDSSLQGET
LKVQELKVSI LALATQILTG CDEVLEMLQQ VTTALINSDI ADREQRLKGL EQVTKATMLG
HLLPVLLTSL MHPNLQTLIM ADALMPQLVQ LVLYTSQTAL LLKTQCPVFA EVGCSPCGAP
DQKCRLFPDE RMLEEKEEPG FLTGLKIPAP WAAGKTVETV HPVRDNYKFK ETVHIPGARC
LYLRFDSRCS SQYDYDKLVI YAGPNTNSRK VAEYGGNTLG YGSRSVLGTG WPKDLVKCIS
PPSLNFKVEG DTVTFSFEMR SGREHNTPDK AMWGFACTVR AQESSEDVSG GLPFLVDLAL
GLSVLACSML RILYNGPEIT KEEEACQELL RSKLLQRCQW QVEANGVISP ALTPSPSPLP
LTIEEDREFT YPSDVLVPPV GNYFDLPRIR LPPGIMIKLR EISGRARPQF RPSIKEVIQP
DVMEEMVVSC VIKHLNLVDA LQSLINFQYQ EEHAEEYDLL CKIMGETFKK LNAMERQLQS
VAELEQKWQS EVDDAMQGKL ENNMPFFYDY HFNENKMKEL ELLCSMKEVS FDGNDLENMV
LSLREKFLQE VNSLIQKPSH PLAKTKTLVK SLMNRAELLL HVTIAAQSGL TRSISGTPAE
TPACKSASET KVISHAVRQP VFLRSMSAPS DLEMIGNEDL EFTRANQRRR HVTSHRSSSF
TLLQSLAIED SRDKPTYSVL LGQLFAFIGT NPDQAVSSSS FLLAAQTRWR RGNTRKQALV
HMRELLTAAV RVGGVTHLVG PVTMVLQGGP RIEELTCGGM VEQVQEAFGE TMTSVVSLCA
RYPIACANSI GLLCTIPYTR SEEKCLVRSG LVQLMDRLCS LSNQTESSSS EKQTKKQKVA
TMAWAAFQVL ANRCVEWEKE EGGSTEAVHS GLARQVSSLL TNHLARATEC CGNQAAGNDA
LQDVLSLLND LSRSHIGKAI LSQPACVSKL LSLLLDQRPS PKLVLIILQL CRAALPLMSV
EDCGNVELPP WSYSVPSLNS EQEDPSDPAS KIASLLLAKL ADYVVPGCQT VLSPTASEPD
TTLTKTSPKN SLKGDKDPGE ESEAVDGKLS IFIHKREDQS SHEVLQPLLS SSEGRPFRLG
TGANMEKVVK MDRDMTKGGC CEVITEEAAA ALRKATKWAQ SGLIVSIGPP VESINPETVS
GLSTGDKKKT AQTSICRERN SELARTDPVR PFISGHVANS MAAEVIALLH SLLMAPESNA
AQIWTTTAEK VLSRALMYIP QLGKYAESIL ENGSSSGRKL AKLQRIARQA VAALCALGGF
KETIKIGSEV QVLGRGISGS IGVVASINEQ EGIATVRFPP IDCRKTSQAS DTLTIPLSRL
CVPRSEALPL HKLSITEKVV QAVQSMLLPQ EGSLSIHTSL PATGDGSAPV MAVVRLLAEI
RTRACLVMAQ LLEDSLFCEE FIQQCPAAVE VLNLVAQECS AGERLAVVEV QCERLRMLYR
DCARPPPPPL QADRRQPKEI TWSPSRVFPP VRACMFSSHL TSVTFLADPS AGGGLPRGTF
IYATSPLPVQ APSFYWEIEI VSYGDTDDDT GPIVSFGFTT EAEKRDGAWT NPVGTCLFHN
NGRAVHYNGS SLLQWKSVRL DVTLSPGDVA GIGWERTEGT PPPPGQPAKG RVYFTYCGQR
LSPYLEDVSG GMWPVVHIQK KNTKTRANFG SRPFAYAEGQ AHRNAADLCT DLAEEISANF
EALPFAMASD SDNDAGTSIA SDPGTHGPPC RIAAVATAQQ QYDSDTSCHY KVELSYENFI
TSGPDPHPPP IADDESDDDD DDDIPQEDHY ALLVKAWETK VFPTIRRRFR NEAERKSGLD
QIKGALQLGM VDIARQTVEF LYEENGGIPR DLYLPTIEDI KDEANKFTID KVRKGLTVVT
RSPDSNNVAS SAVGTALPKF AIRGMLKTFG LHGVVLDVDS VNELVQVETY LRSEGVLVRY
WYPIDMLERP PAGYRRTATN GLVTLDNTNL QIHRELLRCE AALARLYCRM ALLNIFAPKL
PHLFTRLFHI PAIRDITLEH LQLLSNQLLA PPLPDGTISS SSILLAQSLQ HCIHSQNCSA
TDLFYQGNSQ TVREWLNVAI TRTLHQGEES LLELTKQICS FLQTAPEQFP SEEFPISESK
VNMDVNFPGA AFVVVSCKES QSGFRKDSSL YKAPWARVLV YGLGHKVKRN GQLNLIEAAC
YPRDASPANT GLAPPPTADQ YPSVVLSTDR VHIKLGVSPP PGAVLVLHSL PLEFPLAMAF
AEQLLSWKSE DSEGKSEDEP DTIPTSVLLQ VVELLGNFLW TTDMAACVKE LVFHLLAELL
RTVHTLEQRR HPAGLSSSIA LQLNPCLAML MALQSELHKL YDEETQNWVS GGACGGSGGA
AAGDQGRFST YFHALMEGCL AVAEVTLPTN MSVTASGVTS ATAPNLSDSS SSSSSSPGQT
PQSPSLLSKR KKVKMKREKA SSSGKRQSSR TVDSDPTVLS IGGSKPEDML WFHRALTLLI
ILRHLTRKDP QGLGVTSDAI ADACQALVGP TAHSRLLVIS GIPTHLDEGV VRGAIRKACN
AHGGVFKDEI YIPLQEEDTK KPKDKAEGGD GKVEPEKTLA FPGTDSMEVS TSSSLTPAMS
ISASASTSQA SICSSQGISQ TVSDLSVDPL PAGLELPIPP GLLEPHAVSS QESLDISLCS
TGSLGSLGSL GEPLDNAETA SVSDMGSMYT VTSLDNQPLA ARPIKGFAVV EIRSRAKIEK
IRASLFNNND LIGLSSLDGE DELMEMSTEE ILTVSVVNQS LFDTQGSPGL EDYFNDKSIK
GEKLVPGARE VLTEIFKSCA HSEQTLSLTP AKPIRVSDIY LSKEQINSQT PGNLLHLFFT
NVRPPKKVLE DQLTQILRKY GVPKPKFDKS KYSKAGKEQH PVKVVSTKRP ITKPPAKDKA
VLNSVSRTAL SEKKPTVKPK SPEKSKPDEK DPEKSPTKKQ EVPEEKYLTL EGFHKFVIDR
ARQDIRSVWR AILSCGYDLH FERCACIDVR HAQKASRKWT LEMDVALVQY INQLCRHLAI
TPARLHPHEV YLDPADAADP RVACLLNVPI ESLRLRFALL QSLNTTLETF FLPLVELRQT
PMYTHSIAAL LKEAKGLIFY DTKVTVMNRV LNATVQRTAD HAAPEITLDP LEIVGGEIRA
SENSYFCQAA RQLASVPSSQ LCVKLASGGD PTYAFNIRFT GEEVHGTSGS FRHFLWQVCK
ELQSSSLSLL LLCPSSAVNK NKGKYILTPS PITYGEEQLL HFLGQLLGIA IRADVPLPLD
LLPSFWKTLV GEPLDPEQDL QEADILTYNY VKKFESINDE TELEALCAEI ASQHLATESP
DSPNKPCCRF TYLTMTGEEV ELCSRGRHIL VAWENKDIYA AAIRSLRLRE LQNVECVTAV
RAGLGSIIPL QLLTMLSPLE MELRTCGLPY INLEFLKAHT MYQVGLMETD QHIEFFWGAL
EMFTQEELCK FIKFACNQER IPFTCPCKDG GPDTAHVPPY PMKIAPPDGT AGSPDSRYIR
VETCMFMIKL PQYSSLEIML EKLRCAIHYR EDPLSG
