HED1_YEAST
ID HED1_YEAST Reviewed; 162 AA.
AC Q03937; D6VS01;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Meiosis-specific protein HED1;
DE AltName: Full=RED1 suppressor protein 1;
GN Name=HED1; OrderedLocusNames=YDR014W-A; ORFNames=YD9335.01;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAD51, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=16818607; DOI=10.1101/gad.1422506;
RA Tsubouchi H., Roeder G.S.;
RT "Budding yeast Hed1 down-regulates the mitotic recombination machinery when
RT meiotic recombination is impaired.";
RL Genes Dev. 20:1766-1775(2006).
CC -!- FUNCTION: Involved in regulation of meiotic recombination and repair of
CC DNA damage. Inhibits RAD51-mediated recombination when the meiotic
CC recombination machinery is impaired. {ECO:0000269|PubMed:16818607}.
CC -!- SUBUNIT: Interacts with RAD51. {ECO:0000269|PubMed:16818607}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16818607}. Chromosome
CC {ECO:0000269|PubMed:16818607}. Note=Localizes as foci on meiotic
CC chromosomes.
CC -!- DEVELOPMENTAL STAGE: Meiosis-specific. {ECO:0000269|PubMed:16818607}.
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DR EMBL; Z49770; CAA89840.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11861.1; -; Genomic_DNA.
DR RefSeq; NP_001035220.1; NM_001184688.1.
DR AlphaFoldDB; Q03937; -.
DR BioGRID; 566604; 10.
DR STRING; 4932.YDR014W-A; -.
DR iPTMnet; Q03937; -.
DR PaxDb; Q03937; -.
DR PRIDE; Q03937; -.
DR EnsemblFungi; YDR014W-A_mRNA; YDR014W-A; YDR014W-A.
DR GeneID; 4036073; -.
DR KEGG; sce:YDR014W-A; -.
DR SGD; S000113613; HED1.
DR VEuPathDB; FungiDB:YDR014W-A; -.
DR HOGENOM; CLU_1636350_0_0_1; -.
DR InParanoid; Q03937; -.
DR OMA; NRRSCSY; -.
DR BioCyc; YEAST:G3O-30129-MON; -.
DR PRO; PR:Q03937; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q03937; protein.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:SGD.
DR GO; GO:0004857; F:enzyme inhibitor activity; IDA:SGD.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:1903873; P:negative regulation of DNA recombinase mediator complex assembly; IDA:SGD.
DR GO; GO:0045950; P:negative regulation of mitotic recombination; IDA:SGD.
DR GO; GO:0007130; P:synaptonemal complex assembly; IGI:SGD.
PE 1: Evidence at protein level;
KW Chromosome; DNA damage; DNA recombination; DNA repair; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..162
FT /note="Meiosis-specific protein HED1"
FT /id="PRO_0000252301"
FT REGION 67..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 162 AA; 18258 MW; CC97293CD51A0FD4 CRC64;
MQQRSNRRSC SYIPLGVHNN AEKSLCTEVA PARKNKRSIT TSPIVNINVV ERRLFNLELE
KQQLRAKNLS ENTGGGSPNG GAYLDAKKGV REQDQYQGGP SKELDRLQPP PSMKKSPPRK
KKSLKDLIYE TNKTFYQVDS NKVKYKVGLS KKQLLPSKTV DN
