ID   HEH1_CAEEL              Reviewed;         154 AA.
AC   O17271;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Putative protein heh-1;
DE   Flags: Precursor;
GN   Name=heh-1; ORFNames=R148.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; FO080850; CCD67216.1; -; Genomic_DNA.
DR   PIR; T32408; T32408.
DR   RefSeq; NP_497671.2; NM_065270.6.
DR   AlphaFoldDB; O17271; -.
DR   SMR; O17271; -.
DR   BioGRID; 40669; 2.
DR   IntAct; O17271; 1.
DR   STRING; 6239.R148.6; -.
DR   EPD; O17271; -.
DR   PaxDb; O17271; -.
DR   PeptideAtlas; O17271; -.
DR   EnsemblMetazoa; R148.6.1; R148.6.1; WBGene00006452.
DR   UCSC; R148.6.1; c. elegans.
DR   WormBase; R148.6; CE31057; WBGene00006452; heh-1.
DR   eggNOG; KOG4063; Eukaryota.
DR   HOGENOM; CLU_109192_1_2_1; -.
DR   InParanoid; O17271; -.
DR   OMA; NLFCWEI; -.
DR   OrthoDB; 1612792at2759; -.
DR   PhylomeDB; O17271; -.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-8964038; LDL clearance.
DR   PRO; PR:O17271; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006452; Expressed in larva and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0032367; P:intracellular cholesterol transport; IEA:InterPro.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   CDD; cd00916; Npc2_like; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033916; ML_Npc2-like.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..154
FT                   /note="Putative protein heh-1"
FT                   /id="PRO_0000019868"
FT   DISULFID        39..50
FT                   /evidence="ECO:0000250"
FT   DISULFID        97..103
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   154 AA;  16657 MW;  E276E490E28A7BDD CRC64;
     MKTVIFLALL GLAAAEFIEI GYKVCKSDGT VSQVKADGCE LTVKDGKKVC LFKKGSRPII
     QIAFKPSKDT DKLKTSVRAK VGGSAMVDFP QTNSDACTYG VKCPVSAGEN QIFEQSISIT
     ENHPAGEVIQ VNWQLTRPDS GKEVCIIFLA EIKE