HEK2_ASHGO
ID HEK2_ASHGO Reviewed; 316 AA.
AC Q756R8;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Heterogeneous nuclear rnp K-like protein 2;
DE AltName: Full=KH domain-containing protein 1;
GN Name=HEK2; Synonyms=KHD1; OrderedLocusNames=AER186C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: RNA-binding protein involved in the correct localization of
CC transcripts in the cell. RNA localization is a widespread mechanism for
CC achieving localized protein synthesis. Involved in structural and
CC functional organization of telomeric chromatin and regulates silencing
CC at the HMR locus (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds RNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, P-body
CC {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, telomere
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HEK2 family. {ECO:0000305}.
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DR EMBL; AE016818; AAS52867.1; -; Genomic_DNA.
DR RefSeq; NP_985043.1; NM_210397.1.
DR AlphaFoldDB; Q756R8; -.
DR SMR; Q756R8; -.
DR STRING; 33169.AAS52867; -.
DR EnsemblFungi; AAS52867; AAS52867; AGOS_AER186C.
DR GeneID; 4621252; -.
DR KEGG; ago:AGOS_AER186C; -.
DR eggNOG; KOG2190; Eukaryota.
DR HOGENOM; CLU_022670_2_0_1; -.
DR InParanoid; Q756R8; -.
DR OMA; SIAKEPH; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0008298; P:intracellular mRNA localization; IEA:EnsemblFungi.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0051252; P:regulation of RNA metabolic process; IBA:GO_Central.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IEA:EnsemblFungi.
DR Gene3D; 3.30.1370.10; -; 3.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR Pfam; PF00013; KH_1; 3.
DR SMART; SM00322; KH; 3.
DR SUPFAM; SSF54791; SSF54791; 3.
DR PROSITE; PS50084; KH_TYPE_1; 3.
PE 3: Inferred from homology;
KW Chromatin regulator; Chromosome; Cytoplasm; mRNA transport; Nucleus;
KW Reference proteome; Repeat; RNA-binding; Telomere; Translation regulation;
KW Transport.
FT CHAIN 1..316
FT /note="Heterogeneous nuclear rnp K-like protein 2"
FT /id="PRO_0000408187"
FT DOMAIN 32..96
FT /note="KH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 143..208
FT /note="KH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 236..301
FT /note="KH 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 34425 MW; C4BC4A4CE02DE2D7 CRC64;
MTMTDSSSPA PEGPAAPAEA AAPAKVDAQA PLVTLRLLLS LKEAARILGR GGNTIDNIRK
ANGVKIGIST KEKSCSDRLL EVTGSIDAVA NSLADVVKVL TADDTNEEDA EPEPEQHIFK
HLNFILPPPS PDEAEDPMKV KQIGNLRLIV TNSQVSSIIG TAGSKIKKLI DTHSSKLVVS
KTFLPDSQDR ILEIQGFPNS IANCIKDISQ TLIKDDVLDT KEKRYYPHSK HSKDIHVTAT
VAIPAEYVGA LLGHGGNRIA NLRKYTRTKI TVAQEPNQNN EREFTITGND QKSVKLAQNM
IMKNLGTEKE RRLEKQ
