ID   HEK2_LACTC              Reviewed;         285 AA.
AC   C5DIR2;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Heterogeneous nuclear rnp K-like protein 2;
DE   AltName: Full=KH domain-containing protein 1;
GN   Name=HEK2; Synonyms=KHD1; OrderedLocusNames=KLTH0E14520g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: RNA-binding protein involved in the correct localization of
CC       transcripts in the cell. RNA localization is a widespread mechanism for
CC       achieving localized protein synthesis. Involved in structural and
CC       functional organization of telomeric chromatin and regulates silencing
CC       at the HMR locus (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds RNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, P-body
CC       {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEK2 family. {ECO:0000305}.
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DR   EMBL; CU928169; CAR23673.1; -; Genomic_DNA.
DR   RefSeq; XP_002554110.1; XM_002554064.1.
DR   AlphaFoldDB; C5DIR2; -.
DR   SMR; C5DIR2; -.
DR   STRING; 559295.C5DIR2; -.
DR   EnsemblFungi; CAR23673; CAR23673; KLTH0E14520g.
DR   GeneID; 8292280; -.
DR   KEGG; lth:KLTH0E14520g; -.
DR   eggNOG; KOG2190; Eukaryota.
DR   HOGENOM; CLU_022670_2_0_1; -.
DR   InParanoid; C5DIR2; -.
DR   OMA; SIAKEPH; -.
DR   OrthoDB; 394765at2759; -.
DR   Proteomes; UP000002036; Chromosome E.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 3.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   Pfam; PF00013; KH_1; 3.
DR   SMART; SM00322; KH; 3.
DR   SUPFAM; SSF54791; SSF54791; 3.
DR   PROSITE; PS50084; KH_TYPE_1; 3.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Cytoplasm; mRNA transport; Nucleus;
KW   Reference proteome; Repeat; RNA-binding; Telomere; Translation regulation;
KW   Transport.
FT   CHAIN           1..285
FT                   /note="Heterogeneous nuclear rnp K-like protein 2"
FT                   /id="PRO_0000408190"
FT   DOMAIN          9..73
FT                   /note="KH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          113..178
FT                   /note="KH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          205..270
FT                   /note="KH 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
SQ   SEQUENCE   285 AA;  31158 MW;  A24857F5AF654E70 CRC64;
     MAEVEHQDTV NHRVLVSLKE AARIIGAQGM TIQKIRESSK VKIGISPHER GCSDRILSCS
     GSAQGVANAI GDVVEVLNQD DSEPETHSYK PLNFILPAPS ATEIQDPESV KRIGNLRLIV
     SNSQVSSIIG TQGSRIKSLI EKHGVKVVAS KNFLPDSQDR VVEIQGFPGA IASCLVDISE
     ILAAEPKPSH EKQYYPHTKS QEEGSVTKDV AIPVEYVGAL LGRGGNRVSS LRKYTKTKVI
     VSDEPDEENN RVFTITGNNQ NSVKLAETML LKNLETEKQR REDKV