ID   HEK2_VANPO              Reviewed;         336 AA.
AC   A7TT46;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Heterogeneous nuclear rnp K-like protein 2;
DE   AltName: Full=KH domain-containing protein 1;
GN   Name=HEK2; Synonyms=KHD1; ORFNames=Kpol_292p3;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: RNA-binding protein involved in the correct localization of
CC       transcripts in the cell. RNA localization is a widespread mechanism for
CC       achieving localized protein synthesis. Involved in structural and
CC       functional organization of telomeric chromatin and regulates silencing
CC       at the HMR locus (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds RNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, P-body
CC       {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEK2 family. {ECO:0000305}.
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DR   EMBL; DS480542; EDO14561.1; -; Genomic_DNA.
DR   RefSeq; XP_001642419.1; XM_001642369.1.
DR   AlphaFoldDB; A7TT46; -.
DR   SMR; A7TT46; -.
DR   STRING; 436907.A7TT46; -.
DR   EnsemblFungi; EDO14561; EDO14561; Kpol_292p3.
DR   GeneID; 5542573; -.
DR   KEGG; vpo:Kpol_292p3; -.
DR   eggNOG; KOG2190; Eukaryota.
DR   HOGENOM; CLU_022670_2_0_1; -.
DR   InParanoid; A7TT46; -.
DR   OMA; SIAKEPH; -.
DR   OrthoDB; 394765at2759; -.
DR   PhylomeDB; A7TT46; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 3.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   Pfam; PF00013; KH_1; 3.
DR   SMART; SM00322; KH; 3.
DR   SUPFAM; SSF54791; SSF54791; 3.
DR   PROSITE; PS50084; KH_TYPE_1; 3.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Cytoplasm; mRNA transport; Nucleus;
KW   Reference proteome; Repeat; RNA-binding; Telomere; Translation regulation;
KW   Transport.
FT   CHAIN           1..336
FT                   /note="Heterogeneous nuclear rnp K-like protein 2"
FT                   /id="PRO_0000408191"
FT   DOMAIN          17..81
FT                   /note="KH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          139..204
FT                   /note="KH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          248..316
FT                   /note="KH 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
SQ   SEQUENCE   336 AA;  37792 MW;  FAB72414E068CAEA CRC64;
     MSDSDSENKQ TTTTATSVTQ RLLLSLKEAA KIIGTKGTKI QKVRDDNNVK IGISERKERC
     SDRILICTGS IEDVSNAIGD ICEILLSEDV VTNDEDSNEK ENDEYNSIED EKFVYPFLNF
     RLAKPTLDEV NDAETLKKII NIRVLVTRAQ CSAIIGTKGD RIKSLIENRG VRMIASNQTL
     PDSDERLLEI QGTSMAITKV LEDINAVISN EVRATREKRY VPHVRRRNQP VSTNTSSNTG
     SSKSFDEEFK SIVKIPEAYV GAIVGRQGNR IANLRKYSKT KIVIEKRASE VSDDAERIFE
     IISNDIKNVE LAESMLKKNL ETEIQRRKEM EETESA