ID   HEK2_ZYGRC              Reviewed;         372 AA.
AC   C5E0I9;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Heterogeneous nuclear rnp K-like protein 2;
DE   AltName: Full=KH domain-containing protein 1;
GN   Name=HEK2; Synonyms=KHD1; OrderedLocusNames=ZYRO0G13112g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: RNA-binding protein involved in the correct localization of
CC       transcripts in the cell. RNA localization is a widespread mechanism for
CC       achieving localized protein synthesis. Involved in structural and
CC       functional organization of telomeric chromatin and regulates silencing
CC       at the HMR locus (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds RNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, P-body
CC       {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEK2 family. {ECO:0000305}.
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DR   EMBL; CU928179; CAR29623.1; -; Genomic_DNA.
DR   RefSeq; XP_002498556.1; XM_002498511.1.
DR   AlphaFoldDB; C5E0I9; -.
DR   SMR; C5E0I9; -.
DR   STRING; 559307.C5E0I9; -.
DR   PRIDE; C5E0I9; -.
DR   EnsemblFungi; CAR29623; CAR29623; ZYRO0G13112g.
DR   GeneID; 8206372; -.
DR   KEGG; zro:ZYRO0G13112g; -.
DR   HOGENOM; CLU_022670_2_0_1; -.
DR   InParanoid; C5E0I9; -.
DR   Proteomes; UP000008536; Chromosome G.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 3.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   Pfam; PF00013; KH_1; 2.
DR   SMART; SM00322; KH; 3.
DR   SUPFAM; SSF54791; SSF54791; 3.
DR   PROSITE; PS50084; KH_TYPE_1; 3.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Cytoplasm; mRNA transport; Nucleus;
KW   Reference proteome; Repeat; RNA-binding; Telomere; Translation regulation;
KW   Transport.
FT   CHAIN           1..372
FT                   /note="Heterogeneous nuclear rnp K-like protein 2"
FT                   /id="PRO_0000408196"
FT   DOMAIN          59..123
FT                   /note="KH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          167..232
FT                   /note="KH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          283..354
FT                   /note="KH 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  40968 MW;  98895350ECFED2F1 CRC64;
     MSDINDPNSI SLPVGSSCTS RGASTETFTT SRSTTLFSSQ QESKDEGNVE LRESITLPTI
     NHRVLLSLKE SAKVIGTKGS TIQNVREINH VKIGLSEKQL GCSDRVLSCA GRIINVAHSL
     GQIVSVLKEG STVSSAEKYA FHFLNPILPP PTRDEFQDLT LDEINKIGTS RLMVTNSQLS
     SIIGKGGARI KSLKERHRVK IVASRDFLPD SDERILEIQG LPNAITNVLL QISKILLNEL
     DITFASERRY YPHLRSSSPS NAVSLAASTS GVQTGASNYL NNEFKATLKI PESYVGAIAG
     RRGNRIANLR KFTKTKIIVE KKIDKTVIDV DPDNRTFIIL GDHFKNVKLA ESMLLKNLDV
     EIEKRKSRLA KK