ID   HELA_LEGPN              Reviewed;        1052 AA.
AC   Q48815;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Protein HelA;
GN   Name=helA;
OS   Legionella pneumophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=446;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8613357; DOI=10.1128/iai.64.5.1532-1540.1996;
RA   McClain M.S., Hurley M.C., Brieland J.K., Engleberg N.C.;
RT   "The Legionella pneumophila hel locus encodes intracellularly induced
RT   homologs of heavy-metal ion transporters of Alcaligenes spp.";
RL   Infect. Immun. 64:1532-1540(1996).
CC   -!- FUNCTION: Presumed to function with HelC and HelB in efflux of an
CC       unidentified substrate.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000305}.
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DR   EMBL; U49498; AAB05679.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q48815; -.
DR   SMR; Q48815; -.
DR   STRING; 91892.BIZ52_11460; -.
DR   PRIDE; Q48815; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CzcA/CusA/SilA/NccA/HelA/CnrA.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
DR   TIGRFAMs; TIGR00914; 2A0601; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1052
FT                   /note="Protein HelA"
FT                   /id="PRO_0000161820"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        878..898
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        903..923
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        934..954
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        979..999
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1011..1031
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1052 AA;  115821 MW;  5C97817D7B13EBCE CRC64;
     MLEKIIRFSL KHRWFVLLFT LVIAILGVYN FQRLPIDAVP DITNVQVQIN TQASGYSPFE
     VEQRITFPIE LAMSGLPSLD YTRSLSRYGL SQVTVVFKDG TNIYFARQLI NERLQEVKDK
     LPPGVETTLG PISTGLGEIF MYTVTNKPNV PISQHYNPTE LRTIQDWIIK PQLRNVEGVA
     EVNTIGGYEK QFHITPDPSK LVRYRLSLND VVEALERNNA NVGAGYIETN GEQNLIRVPG
     QVQNMADIEN IVIASFEGTP VRIRDVAEVA LGKELRTGAA TENSKEVVLG TVFILMGENS
     RTVSERVAAK MKDINKTLPE GVEAITVYNR TTLVNATINT VKNNLLEGAL LVCVILFLFL
     GNIRAALITA MVIPLSMLLT ITGMVENQIS ANLMSLGALD FGLIVDGAVI IVENCIKHLA
     EQQHALHRVL NLEERLKVIS YATTEVIRPS IFGVFIITVV YLPILTLTGV EGKMFLPMAQ
     TVIIALLASM LFALTFVPAA VAIFLRGHLQ EKENWLVHYL SLGYAKVLRR CFHARRVVIS
     AAVALVVVSL GIAFHLGGEF IPSLDEGDIA MHAMRIPGTS LTQAITMQDL VEKRIRQFSE
     VKNVFAKLGT AEVATDPMPP NVADTFIILK SRKKWTNPKK TKPGLVQEIE SAVQQIPGNN
     YEFTQPIQMR FNELISGVRS DVAVKVFGDD MDTLLKTAEA ISAQLKQVPG AADVKVEQVS
     GLPLLTVEIN RDVLARYGLQ IGTVQEAVVI ATGGKKGGEL FEGDKRFDIV VRLPESLRSD
     PNVLRQIFIP LPLSKDGEQH FIPLSEVASL IRSESPNQIS RENGKRRVVV TANVRNRDLS
     SFVSEAKKRI DGQVKLPSGY WITWGGQFEQ LQSAYQRLQI VVPITLLGIF LLLFISFGKV
     RDALLVFTGI PLALTGGVFA LWLRGIPLSI SAGVGFIALS GVAVLNGLVM ITFINKLREQ
     KKVYLKDAVL QGSLARLRPV LMTALVASLG FVPMALATGT GSEVQRPLAT VVIGGIISST
     FLTLLVLPGL YYVFHGRRKK GQSKSEPQEQ IM