HELCL_DICDI
ID HELCL_DICDI Reviewed; 2237 AA.
AC Q55CI8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3-like;
DE EC=3.6.4.-;
GN Name=ascc3l; ORFNames=DDB_G0270042;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the helicase family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72371.1; -; Genomic_DNA.
DR RefSeq; XP_646493.1; XM_641401.1.
DR AlphaFoldDB; Q55CI8; -.
DR SMR; Q55CI8; -.
DR STRING; 44689.DDB0233131; -.
DR PaxDb; Q55CI8; -.
DR PRIDE; Q55CI8; -.
DR EnsemblProtists; EAL72371; EAL72371; DDB_G0270042.
DR GeneID; 8617455; -.
DR KEGG; ddi:DDB_G0270042; -.
DR dictyBase; DDB_G0270042; ascc3l.
DR eggNOG; KOG0951; Eukaryota.
DR HOGENOM; CLU_000335_1_0_1; -.
DR InParanoid; Q55CI8; -.
DR OMA; ESFWIIV; -.
DR PhylomeDB; Q55CI8; -.
DR Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-DDI-72165; mRNA Splicing - Minor Pathway.
DR PRO; PR:Q55CI8; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005681; C:spliceosomal complex; ISS:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0008380; P:RNA splicing; ISS:dictyBase.
DR GO; GO:0000388; P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11); IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 2.
DR Gene3D; 2.60.40.150; -; 2.
DR Gene3D; 3.40.50.300; -; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF46785; SSF46785; 2.
DR SUPFAM; SSF52540; SSF52540; 4.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Helicase; Hydrolase; Nucleotide-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..2237
FT /note="Activating signal cointegrator 1 complex subunit 3-
FT like"
FT /id="PRO_0000371331"
FT DOMAIN 561..745
FT /note="Helicase ATP-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 755..990
FT /note="Helicase C-terminal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT DOMAIN 1050..1356
FT /note="SEC63 1"
FT DOMAIN 1407..1584
FT /note="Helicase ATP-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 1657..1832
FT /note="Helicase C-terminal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT DOMAIN 1892..2215
FT /note="SEC63 2"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 440..468
FT /evidence="ECO:0000255"
FT MOTIF 687..690
FT /note="DEAH box"
FT MOTIF 1526..1529
FT /note="DEAH box"
FT COMPBIAS 25..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..278
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 574..581
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT BINDING 1420..1427
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 2237 AA; 256437 MW; BCA42D336175EA06 CRC64;
MSEELARSKQ YGYKENSNLV FYSERNRSEL KEPKGEPETL WGRLRGEMGD RVNYSKPLEL
LEKMQNLKRK TIEKEGGDVN SSNDTYSTTK KVKNQNPLEK KSTNRKSNGN NNNEKPIDIL
SATESFQGLY KPKTKETRIT YETLLTFIQR YVGDQPTEVV KGALDEILSI LKDDTIRAPE
KKIEISKLLK GLNDVSFAEL TQLGKQITDF KDSELAKQQQ QQQQQQSMDS LDDEQGVAVI
IDEEEEEENL SDFEIRDDDD DDDDVDNNEV DDNNNNDSEA QDSEIQTKDE NNNDDDENQK
IKENNNNNNK SQKPDTKNTK DDKNNNSKLI SPNEIDSFWI QRKISEFERD HDLSKQLAEK
TLNILRQPNV RRCEQQLVDL FTIDKLDFLK LIINNKQTIL YCTLLAKAEN DQERKKIEDE
MSSNPVTLSI LNRLKGNEVT AATTEKTIEK TESNKKDVEM KQQQQQQQDE IKKPKKLLNL
EELSFQQGSH LMTNKEFKFP KGSKREQYKG FEEIHVPARA NPPFNPNERL ISIEELPEWS
RLPFEESGVK SLNRVQSKLF DCAFKTDNNL LLSAPTSSGK TNVAMLTILH EIGKNRDRDS
GKIRLDAFKI VYIAPMKSLV QEMVGNFSKR LKSYGIVVNE LTGDQSLTNK QISETQIIVT
TPEKWDIITR KSGDRAYTQL VKLIIIDEIH LLHDERGPVL ECIVARTLRM IESTQQMVRL
VGLSATLPNY EDVATFLRVE PDGVFYFDSS YRPIPLEQQY IGISDRGIKQ LQRCNDITFT
KVSERVGDHQ ILIFVHSRRE TAKTGKDLRD RAVEDQSIDR YIRDPASREI LRATASKQIQ
NAELKDLLPY GIGIHHAGLS RSDRSLVEDL FGDNRIQVLI STATLAWGVN LPAHTVIIKG
TQIYNPEKGW CELSPLDVTQ MLGRAGRPPF DKEGEGIIIT SQHELQFYLS LLNTQLSIES
QFISRIADNL NAEIVLGSIQ TVRDAVNWLG YTYLYICMIR NPPLYEISYD DFEKDPLLEQ
RRLDLVHSAA TILEKNSLIK YDRKSGKLQS TELGKVASHY YITNSSMSIY QEHLKPSMSD
IELLRVFSLS SEFKNVVVRE GEKFELEKLL ERVPIPIKEN IEEPSSKINV LLQTYISNLK
LDGFALVVDM FYIAQSASRI TRALFEIVLK KGWAQLAKKI LNLAKMIDSK MWSSQSPLRQ
FHKISPKVLN QLERRGIPIE DLYEYNSQQL GNAIQNPSEG KQLFDLIHNF PKLDLTAHVQ
PILHGLLRVE LSITPDFQYD ERYHNNSIGW WIIVEDVDGE RILYFEYFSL KKKMVNGEDQ
LVSFTVPLSQ PLPPQYYVRV ISDHWIGAEY SLPISFQHLI LPEKYPPCRP LLDLQPLPIQ
VLKDPKAESI FKPTFSIFNA IQTQVFNCMY QSNDNAFISA PTNSGKTVCA EIALIRCFKQ
NPKAKVVYLA PMQDLASVRL KDWSNKFGVK SPFGLVVSDL TGDAVTDNKI LDRSNIIVTN
CEKWDILSRK WKQRKALQSI NLLIVDELHL IGGEYGPTME IVVSRMRYIS TQTGNALRVI
ALSSSIANAR DLVLWIGATP QTCYNFHPNV RPIPVEYQIQ GFEFPHFNAR MLAMTKPTVY
EVAKNKNQQS IVFVPTRKLS RSLAADIIAN VSSFEDTLTK PYLVCEEHVL TPYLEDVDSF
ALKQSLQMGV AFYHDGLTER ERRVVEILFR SGSIRVLIAT HSVAWLLDNV FAQLVVIMGT
QLYQGKDIRY IDYPINDILQ MIGRAGKQEG GGVISNKVAK VLLLCHAPKK EYYKMFLNEP
LPVESHLDHC LHDQFNSEIV TKTITKKQDA LDYLTWTFLY RRLNQNPNYY NLSGVSHLHL
SEHLSELVEN TLVELEQSNC ITIQDDQDKV SPLNLGIIAS YYYLKYQTIE LFGSSLKSTT
RRRGIMDIIS NAPEFNSLPI RHREDQILMK LASHLPQKID KPNYQEISTK VNVLLQCHFS
RESISADLYQ DQKFILENAT RLLQAIVDVI SSNSWLQPAI AAMELSQMIT QAMWDSDSVF
KQLPHMNKRR IDAITSQGIE SVFDLMSLDD NSRIQLLDLS QQESNDLVQS FMKYPDIDIS
YQVQDEDDLH ADSIMTVEMV IERDLGDDEE NPIEINDSIN VVSAPYYPKE KICGWWALIG
DSKNNHLLAI KRITFLKKTK VKFEFPTPAV GKHQLSLYLF SDSYNGCDQE HELNINILPA
EIEDEDEDEE EDNEMDE
