ID   HELI_ALHV1              Reviewed;         783 AA.
AC   O36393;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA replication helicase {ECO:0000255|HAMAP-Rule:MF_04030};
DE            EC=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_04030};
GN   Name=HELI {ECO:0000255|HAMAP-Rule:MF_04030}; OrderedLocusNames=44;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase elongates using
CC       dNTPs. Possesses helicase-like motifs and therefore may act as the
CC       helicase subunit of the complex. {ECO:0000255|HAMAP-Rule:MF_04030}.
CC   -!- SUBUNIT: Associates with the primase and the primase-associated factor
CC       to form the helicase-primase complex. {ECO:0000255|HAMAP-
CC       Rule:MF_04030}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04030}.
CC   -!- SIMILARITY: Belongs to the herpesviridae helicase family.
CC       {ECO:0000255|HAMAP-Rule:MF_04030}.
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DR   EMBL; AF005370; AAC58090.1; -; Genomic_DNA.
DR   PIR; T03138; T03138.
DR   RefSeq; NP_065542.1; NC_002531.1.
DR   GeneID; 911763; -.
DR   KEGG; vg:911763; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_04030; HSV_HELI; 1.
DR   InterPro; IPR003840; DNA_helicase.
DR   InterPro; IPR034711; HSV_HELI.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02689; Herpes_Helicase; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Helicase; Host nucleus; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..783
FT                   /note="DNA replication helicase"
FT                   /id="PRO_0000405739"
FT   BINDING         64..71
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04030"
SQ   SEQUENCE   783 AA;  87663 MW;  F6C081D087D96169 CRC64;
     MEHIPKSFIL NMTSEAKVRM IVQKIKALSE ETTSDSPDIS WFDAEFDPDD LGPRLPFSTY
     CITGTAGAGK STSIAALHQN LNCLITGATV VAAQNLSKTL HSFCPTIYTA FGFKSRHINL
     LNRKPQIKLC GDSDITAVQY YELSKYWPVI KDIIGEFCKK KKFGLYASMS EEAYRVFGCL
     GSPQLWTTNI IIIDEAGTLS SHVLMAVVFL WWFFNGWLNT RQYLNGKIPC IVCVGSPTQT
     DAYHSQFDHS KQQQHVRECD NVLSLIIGNK TVSDYVKISE NWALFINNKR CTDPEFGHML
     KVLEYGLEIS DDVMEYINRL VVPRSKIMDP MQYVGWTRLF LSHSEVKQYL GSLHSALSSN
     QSSTTCTLFT CPIVCEVFHD AVEEYKEAVN VPSLTPLEWL ARNTYRLSNY SQFIDQDMTT
     VSTDVGEAST KVTYATKFVK GSYVSVNGKT KKCFMGFMGT YAQFKRVLDS ESFLDTHGHE
     QPEHAYAFLC QLLYNSMYNF YQAAVQSDCA SYISALNNIP IPEVLCAPAH SELACSEPLN
     EGEDLFYHKT LPPPTARSTS LANIIAIYQG LKDIFIARME AATRYQMPNF GYSSFNTFLS
     NTIVKNNVDF VSAEPISGLL DYASTVESYM LQGYTFSPIY FGKLPLQSTL SKDLRDKLPN
     LVVRDADGFI CCLDNNLTKM TENLESGAQI HMCSVGDYGI SSKLAMTIAK AQGLSLDKVA
     VCFGNHQKIK RSHVYVALSR ATDANNLVID SNPLSNRECE MDICKSSKHI VAALCNPQTL
     LIY