ID   HELI_GAHVM              Reviewed;         858 AA.
AC   Q9E6R1;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=DNA replication helicase {ECO:0000255|HAMAP-Rule:MF_04030};
DE            EC=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_04030};
GN   Name=HELI {ECO:0000255|HAMAP-Rule:MF_04030}; OrderedLocusNames=MDV017;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase elongates using
CC       dNTPs. Possesses helicase-like motifs and therefore may act as the
CC       helicase subunit of the complex. {ECO:0000255|HAMAP-Rule:MF_04030}.
CC   -!- SUBUNIT: Associates with the primase and the primase-associated factor
CC       to form the helicase-primase complex. {ECO:0000255|HAMAP-
CC       Rule:MF_04030}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04030}.
CC   -!- SIMILARITY: Belongs to the herpesviridae helicase family.
CC       {ECO:0000255|HAMAP-Rule:MF_04030}.
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DR   EMBL; AF243438; AAG14197.1; -; Genomic_DNA.
DR   RefSeq; YP_001033933.1; NC_002229.3.
DR   GeneID; 4811478; -.
DR   KEGG; vg:4811478; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_04030; HSV_HELI; 1.
DR   InterPro; IPR003840; DNA_helicase.
DR   InterPro; IPR034711; HSV_HELI.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02689; Herpes_Helicase; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Helicase; Host nucleus; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..858
FT                   /note="DNA replication helicase"
FT                   /id="PRO_0000406580"
FT   BINDING         75..82
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04030"
SQ   SEQUENCE   858 AA;  97204 MW;  127F4458DD9CDD83 CRC64;
     MSQESNDLFC EATYLNFTAM HGIQSIITRV RALADATLSD ELIPPLSYFI EASNHENPVE
     LEARDLPFAV YLISGNAGSG KSTCIQTLSE ILDCIITGTT KVASQNIYCK LSNSYTSPHI
     NTIFQEFGFK GNHVQANLGK WQYVCSTSPP TMKELQKKDI VYYWEVLSDI TKSMLKVLDS
     ETGPGKFDVI RTLEDLLGKP RGNLSWMTFG IHGSLPSFTR SNIIIIDEAG LLGKYLLTAI
     VYCWWLTNAV YRTPQYKRGL KPVLICVGSP TQTSSLESTF EHSKLRCNVR ISENILTYII
     CNQTLRSYLD LSNNWAIFIN NKRCTEPEFG DLLKTLEYGL PITEEHARMA DNFVVPEAFI
     NNPANLPGWT RLYSSHKEVS TYMSRLHDYL KTSGNNKFVV FTLPAYTFIS LENFERYRTA
     ANQPHITLEK WLNVNAGRLS NWSQSRDQDA TQTRCEIRSQ QGLAISCSDI TYVLNSQVAV
     TTRLRKWVFG FCGTFENFLS VLKDDSFIKT HGEGSIEYAY RFLSHLLFNG MINFYNYLQQ
     RSLSEHAVKT AYNKLATLTN TILFPQRQLS AGDGENFNDV IVPTDLCHFE GKGIEDVDIQ
     QRHENVDDVI FSALDDQMID LLYCNYEFGH AETSSEIYTQ FSMLKTMFMG RYSIMVELFG
     RNFSTSRFDS YVDNVSSRGC EIFINNMRGG MLSLALQTDS YTLMGYTFAR VNAFADEPIR
     RKIQPHVAEV LGELNMPTIV LKDQHGFMAA VNSNINDFVE SVDDHELKMA VTADYGISSK
     LAMTIARSQG LSLERVAICF AHSGLKLSSV YVAMSRVTSS KYLRMNINPL RETHSRDDNN
     ISEHLLAALR DPKVHIVY