ID   HELI_HHV7J              Reviewed;         820 AA.
AC   P52357;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA replication helicase {ECO:0000255|HAMAP-Rule:MF_04030};
DE            EC=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_04030};
GN   Name=HELI {ECO:0000255|HAMAP-Rule:MF_04030}; OrderedLocusNames=U77;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase elongates using
CC       dNTPs. Possesses helicase-like motifs and therefore may act as the
CC       helicase subunit of the complex. {ECO:0000255|HAMAP-Rule:MF_04030}.
CC   -!- SUBUNIT: Associates with the primase and the primase-associated factor
CC       to form the helicase-primase complex. {ECO:0000255|HAMAP-
CC       Rule:MF_04030}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04030}.
CC   -!- SIMILARITY: Belongs to the herpesviridae helicase family.
CC       {ECO:0000255|HAMAP-Rule:MF_04030}.
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DR   EMBL; U43400; AAC54738.1; -; Genomic_DNA.
DR   PIR; T41978; T41978.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_04030; HSV_HELI; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003840; DNA_helicase.
DR   InterPro; IPR034711; HSV_HELI.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02689; Herpes_Helicase; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Helicase; Host nucleus; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..820
FT                   /note="DNA replication helicase"
FT                   /id="PRO_0000115851"
FT   BINDING         90..97
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04030"
SQ   SEQUENCE   820 AA;  92914 MW;  FC2E3CFC88B224D3 CRC64;
     MSLSSLFNGK YDTKFLLNMS SAAKVELIVE KVAALADACL ETPLPTDWFR NILDPELEFN
     SNFEEIHSIG DEEFAQPLPF LPFRVLLITG TAGAGKTSSI QTLAANSDCL ITATTSIAAQ
     NLSGLLNRTK SAQVKTIFKT FGFNSSHVSM NERISCSVTT LDSIADQQKH DLSTYWNVIA
     DIAERALNAA NGKTKVIPDL CESSVIVIDE AGVILRHILH TVVFFYWFYN GLHKTQLYKN
     RVIPCIVCVG SPTQSGALIS SFNPLTQNKD VKKGFDILSA LICDDILSNY CKISENWVIF
     VNNKRCTDVE FGEFLKHIEF GLPLKPELIE YVDRFVRPAT YIRNPTNEIG MTRLFLSHYE
     VKSYFKVLHE QVELTNKDNL FTFPVYFIIQ NKAFEDYKNE ISNFTLEIEP WFKTNLHRLN
     TYSQFADQDL SKTIQIEEIV LDDGSVEETL ITCHLKHIKH SSIGVTSRTK SSTVGFSGTY
     EKFVELLQSD LFIEKTACEY SVHAYSFLTG LMYGGMYSFC LSEFTTSEVM TEIRKIKLPN
     IDFLQTMTAE VSLQTFDESD EYYDLHIAPT DEEMLASDPC PDPFFLKYKQ LPLTNVLTFE
     EISYLYTVFK EIFISRFAIL QRHSKEMFGK SNLITYNRNN VSSKRCGEIC SHVKSFYGML
     TYAVPANNYT LEGYTYDNVI FLGTDKMLPP IIYKRGLPKI VIKDEMGFIS ILDNNVSKLT
     DTVNGNSFHI CTTIDYAIVS KVAMTVTKSQ GLSIQRVALD FGNDPKNLKL SSIYVGMSRV
     VDPNNLIMNL NPLRLNYEND NIIASHIVKA LKNKDTMLIF