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HELI_PSHV1
ID   HELI_PSHV1              Reviewed;         855 AA.
AC   Q6UDG9;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=DNA replication helicase {ECO:0000255|HAMAP-Rule:MF_04030};
DE            EC=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_04030};
GN   Name=HELI {ECO:0000255|HAMAP-Rule:MF_04030}; OrderedLocusNames=UL5;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase elongates using
CC       dNTPs. Possesses helicase-like motifs and therefore may act as the
CC       helicase subunit of the complex. {ECO:0000255|HAMAP-Rule:MF_04030}.
CC   -!- SUBUNIT: Associates with the primase and the primase-associated factor
CC       to form the helicase-primase complex. {ECO:0000255|HAMAP-
CC       Rule:MF_04030}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04030}.
CC   -!- SIMILARITY: Belongs to the herpesviridae helicase family.
CC       {ECO:0000255|HAMAP-Rule:MF_04030}.
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DR   EMBL; AY372243; AAQ73741.1; -; Genomic_DNA.
DR   RefSeq; NP_944435.1; NC_005264.1.
DR   PRIDE; Q6UDG9; -.
DR   GeneID; 2656955; -.
DR   KEGG; vg:2656955; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_04030; HSV_HELI; 1.
DR   InterPro; IPR003840; DNA_helicase.
DR   InterPro; IPR034711; HSV_HELI.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02689; Herpes_Helicase; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Helicase; Host nucleus; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..855
FT                   /note="DNA replication helicase"
FT                   /id="PRO_0000406834"
FT   BINDING         78..85
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04030"
SQ   SEQUENCE   855 AA;  95258 MW;  B1A7E3BA523B5E25 CRC64;
     MAEDRGTRLW QFPDHVYLNF TAMHGIQHVV DRISSLAEES VTPAERPPLS WFEAVARADS
     PDEVPPRELP FRVYLITGNA GSGKSTCIQA LTEMLNCVTT GSTRVAALNV FTKLSSAYTS
     PAIQTIFHDF GFKGSHVQAV LGKFKYPKQP DPKSLVDAQM SDLYYYWDVL KDIANKVVEG
     GLPETMRVLL SLELKSGKPF TDAAPFLSAA TPALIRSNVV LIDEAGVLGK HILTAVVFSW
     WLHNALWQTR RYAEGKVPVI VCIGSPTQTD AMESVFEHST LRHLVSNKTN ILSHLIRSSE
     MAERMNLNRN WTIFINNKRC TEQDFGNVLK AFEFGLPMNE GHARFLDQFV VSESYIKDPS
     KLPGWTRLFA SHDDVKVYMS RLHANLRARR SDKFKVFVLP IYTVVSLEAF DKYKELTGQT
     SLTMEKWLTA NASRLGNYSQ SRDLDVTTPR FEYGTADGKK FALITTDASH VLNSQISVTK
     RVKKLVFGFE GSFGDFAAVL SEDTFFKKHG EDHVEFAYRF IAALLFSGMI AFYDFLRTEG
     LPQDKVDAAY SRLQAVTADL LAATHEQLGI AAAAGAQTGS GARRSRNADA FAFDDDASEE
     VTDAELDDLF GAMTDNSMDA FYLNYEKLPA DAHGQEIFFH FDMLKRLFSE RYDALSGLFG
     KTFTSAPFRT FVGQASFNGS NAFVSSFSGG ILSFTSQTDA YTLRGVTRAP VPCFVDELFR
     GRDWAAAILR ETDMPRVVVS DSMGFVSVIN HNMSTFVDNV SGEELQMAAT VDHGISSNLA
     MTITRSQGLG LDRVAICFAT SQLKLNTAYV AMSRVTSCRY LRMNVNPLRT HYEDTRRVSA
     HILAALRCKD VKLVY
 
 
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