HELI_VZVO
ID HELI_VZVO Reviewed; 881 AA.
AC Q9J3N5; Q4JQS0; Q4JR29;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=DNA replication helicase {ECO:0000255|HAMAP-Rule:MF_04030};
DE EC=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_04030};
GN Name=HELI {ECO:0000255|HAMAP-Rule:MF_04030}; OrderedLocusNames=ORF55;
OS Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=341980;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=10720545; DOI=10.1086/315335;
RA Argaw T., Cohen J.I., Klutch M., Lekstrom K., Yoshikawa T., Asano Y.,
RA Krause P.R.;
RT "Nucleotide sequences that distinguish Oka vaccine from parental Oka and
RT other varicella-zoster virus isolates.";
RL J. Infect. Dis. 181:1153-1157(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC Oka varicella vaccine Varivax (V-Oka-Merk);
RX PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA Vassilev V.;
RT "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL J. Virol. 82:11023-11044(2008).
CC -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC the replication forks and generates single-stranded DNA for both
CC leading and lagging strand synthesis. The primase synthesizes short RNA
CC primers on the lagging strand that the polymerase elongates using
CC dNTPs. Possesses helicase-like motifs and therefore may act as the
CC helicase subunit of the complex. {ECO:0000255|HAMAP-Rule:MF_04030}.
CC -!- SUBUNIT: Associates with the primase and the primase-associated factor
CC to form the helicase-primase complex. {ECO:0000255|HAMAP-
CC Rule:MF_04030}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04030}.
CC -!- SIMILARITY: Belongs to the herpesviridae helicase family.
CC {ECO:0000255|HAMAP-Rule:MF_04030}.
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DR EMBL; AF206304; AAF61656.1; -; Genomic_DNA.
DR EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ008354; AAY57664.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57735.1; -; Genomic_DNA.
DR IntAct; Q9J3N5; 4.
DR MINT; Q9J3N5; -.
DR ChEMBL; CHEMBL4523677; -.
DR PRIDE; Q9J3N5; -.
DR Proteomes; UP000002603; Genome.
DR Proteomes; UP000008504; Genome.
DR Proteomes; UP000008505; Genome.
DR Proteomes; UP000008506; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_04030; HSV_HELI; 1.
DR InterPro; IPR003840; DNA_helicase.
DR InterPro; IPR034711; HSV_HELI.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF02689; Herpes_Helicase; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Helicase; Host nucleus; Hydrolase;
KW Nucleotide-binding.
FT CHAIN 1..881
FT /note="DNA replication helicase"
FT /id="PRO_0000385138"
FT BINDING 90..97
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04030"
FT VARIANT 492
FT /note="T -> S"
SQ SEQUENCE 881 AA; 98893 MW; 5D3290EDB2E489F6 CRC64;
MKRSISVDSS SPKNVFNPET PNGFDDSVYL NFTSMHSIQP ILSRIRELAA ITIPKERVPR
LCWFKQLLEL QAPPEMQRNE LPFSVYLISG NAGSGKSTCI QTLNEAIDCI ITGSTRVAAQ
NVHAKLSTAY ASRPINTIFH EFGFRGNHIQ AQLGRYAYNW TTTPPSIEDL QKRDIVYYWE
VLIDITKRVF QMGDDGRGGT STFKTLWAIE RLLNKPTGSM SGTAFIACGS LPAFTRSNVI
VIDEAGLLGR HILTAVVYCW WLLNAIYQSP QYINGRKPVI VCVGSPTQTD SLESHFQHDM
QRSHVTPSEN ILTYIICNQT LRQYTNISHN WAIFINNKRC QEDDFGNLLK TLEYGLPITE
AHARLVDTFV VPASYINNPA NLPGWTRLYS SHKEVSAYMS KLHAHLKLSK NDHFSVFALP
TYTFIRLTAF DEYRKLTGQP GLSVEHWIRA NSGRLHNYSQ SRDHDMGTVK YETHSNRDLI
VARTDITYVL NTLVVVTTRL RKLVIGFSGT FQSFAKVLRD DSFVKARGET SIEYAYRFLS
NLIFGGLINF YNFLLNKNLH PDKVSLAYKR LAALTLELLS GTNKTPLHEA AVNGAGAGID
CDGAATSADK AFCFTKAPES KVTASIPEDP DDVIFTALND EVIDLVYCQY EFSYPKSSNE
VHAQFLLMKA IYDGRYAILA ELFESSFTTA PFSAYVDNVN FNGSELLIGN VRGGLLSLAL
QTDTYTLLGY TFAPVPVFVE ELTRKKLYRE TTEMLYALHV PLMVLQDQHG FVSIVNANVC
EFTESIEDAE LAMATTVDYG LSSKLAMTIA RSQGLSLEKV AICFTADKLR LNSVYVAMSR
TVSSRFLKMN LNPLRERYEK SAEISDHILA ALRDPNVHVV Y