ID   HELN_HELVI              Reviewed;          22 AA.
AC   P83427;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Heliocin;
OS   Heliothis virescens (Tobacco budworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Heliothinae; Heliothis.
OX   NCBI_TaxID=7102 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-1, AND
RP   GLYCOSYLATION AT THR-7.
RC   TISSUE=Hemolymph;
RA   Bulet P., Lamberty M., Charlet M., Sabatier L., Rabel D.;
RL   Submitted (JUL-2002) to UniProtKB.
CC   -!- FUNCTION: Has antibacterial activity, preferentially against Gram-
CC       negative bacteria. {ECO:0000269|Ref.1}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Hemolymph. {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2901.89; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the lebocin family. {ECO:0000305}.
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DR   PDB; 4EZT; X-ray; 2.00 A; B=14-21.
DR   PDBsum; 4EZT; -.
DR   AlphaFoldDB; P83427; -.
DR   SMR; P83427; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Direct protein sequencing;
KW   Glycoprotein; Immunity; Innate immunity; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..22
FT                   /note="Heliocin"
FT                   /id="PRO_0000043594"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..22
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|Ref.1"
FT   CARBOHYD        7
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   22 AA;  2714 MW;  1F4368EB8817F059 CRC64;
     QRFIHPTYRP PPQPRRPVIM RA