HELS_AERPE
ID HELS_AERPE Reviewed; 735 AA.
AC Q9YFQ8;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
GN OrderedLocusNames=APE_0191.1;
OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS K1).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Aeropyrum.
OX NCBI_TaxID=272557;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
CC -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC involved in repair of stalled replication forks. {ECO:0000255|HAMAP-
CC Rule:MF_00442}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00442}.
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DR EMBL; BA000002; BAA79103.2; -; Genomic_DNA.
DR PIR; E72775; E72775.
DR AlphaFoldDB; Q9YFQ8; -.
DR SMR; Q9YFQ8; -.
DR STRING; 272557.APE_0191.1; -.
DR EnsemblBacteria; BAA79103; BAA79103; APE_0191.1.
DR KEGG; ape:APE_0191.1; -.
DR PATRIC; fig|272557.25.peg.136; -.
DR eggNOG; arCOG00553; Archaea.
DR Proteomes; UP000002518; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00442; Helicase_Hel308; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR022965; Helicase_Hel308.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..735
FT /note="ATP-dependent DNA helicase Hel308"
FT /id="PRO_0000102103"
FT DOMAIN 37..201
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT DOMAIN 235..431
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT MOTIF 146..149
FT /note="DEAH box"
FT BINDING 32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT BINDING 50..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
SQ SEQUENCE 735 AA; 80474 MW; A8FAA24626B2C5C3 CRC64;
MSKGLYDIPS WATTETRTLA KLAGVERLFE PQYMALQAGV EKGENLVVAA PTGSGKTFIA
LVAIVNSLAR AGGRAFYLVP LKSVAYEKYT SFSILSRMGL KLKISVGDFR EGPPEAPVVI
ATYEKFDSLL RVSPSLARNV SVLIVDEIHS VSDPKRGPIL ESIVSRMLAS AGEAQLVGLS
ATVPNAGEIA EWIGGKIVES SWRPVPLREY VFKEYKLYSP TGGLREVPRV YGLYDLDLAA
EAIEDGGQAL VFTYSRRRAV TLAKRAAKRL GRRLSSREAR VYSAEASRAE GAPRSVAEEL
ASLIAAGIAY HHAGLPPSLR KTVEEAFRAG AVKVVYSTPT LAAGVNLPAR RVVIDSYYRY
EAGFREPIRV AEYKQMAGRA GRPGLDEFGE AIIVAERLDR PEDLISGYIR APPERVESRL
AGLRGLRHFI LGIVAPEGEV SIGSIEKVSG LTLYSLQRGL PRETIARAVE DLSAWGLVEV
KGWRIAATSL GREVAAVYLD PESVPVFREE VKHLSFDNEF DILYLISTMP DMVRLPATRR
EEERLLEAIL DASPRMLSSV DWLGPEEMAA VKTAVVLKLW IDEASEDTIY GEWGVHTGDL
LNMVSTAEWI ASGLSRIAPY LGLNSKVSHI LSVIARRIKH GVKPELLQLV EIPGVGRVRA
RILFEAGYRS IEDLATARAE DLMRLPLIGP STARQILEFL GRVDEAREAE AREMLARKGL
LSYLEGDAVA GEEGE