ID   HELS_HALMA              Reviewed;         799 AA.
AC   Q5UYM9;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442}; OrderedLocusNames=rrnAC2876;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC       involved in repair of stalled replication forks. {ECO:0000255|HAMAP-
CC       Rule:MF_00442}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
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DR   EMBL; AY596297; AAV47624.1; -; Genomic_DNA.
DR   RefSeq; WP_011224485.1; NZ_CP039138.1.
DR   AlphaFoldDB; Q5UYM9; -.
DR   SMR; Q5UYM9; -.
DR   STRING; 272569.rrnAC2876; -.
DR   EnsemblBacteria; AAV47624; AAV47624; rrnAC2876.
DR   GeneID; 40153720; -.
DR   KEGG; hma:rrnAC2876; -.
DR   PATRIC; fig|272569.17.peg.3445; -.
DR   eggNOG; arCOG00553; Archaea.
DR   HOGENOM; CLU_006553_3_0_2; -.
DR   OMA; MFLNANI; -.
DR   Proteomes; UP000001169; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00442; Helicase_Hel308; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR022965; Helicase_Hel308.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..799
FT                   /note="ATP-dependent DNA helicase Hel308"
FT                   /id="PRO_0000102104"
FT   DOMAIN          34..200
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   DOMAIN          234..435
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   REGION          522..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          750..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           145..148
FT                   /note="DEAH box"
FT   BINDING         29
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   BINDING         47..54
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
SQ   SEQUENCE   799 AA;  86768 MW;  6C95712556AE86CF CRC64;
     MDVADLPGVP EWLPDHLRDD GIEELYPPQA EAVEAGVTEG ENLVASIPTA SGKTLIAELA
     MLSSVARGGK ALYIVPLRAL ASEKQADFEE FEQYGLDIGV STGNYESEGG WLADKDIVVA
     TSEKVDSLVR NDAPWIEDLT CVVTDEVHLV DDGERGPTLE VTLAKLRRLN PDLQTVALSA
     TIGNAEALAT WLDAGLVDSD WRPIDLQKGV HYGQALHLED GSQQRLSVQN NEKQTAAIVR
     DTLEDDGSTL VFVNSRRNAE AAAGRLANTV RPHLSTEERD QLADIAEEIR DVSDTETSDD
     LADAVADGAA FHHAGLSRGH RELVEDAFRD RLVKVVCATP TLAAGVNTPS RRVVVRDWRR
     YDGSAGGMAP LSVLEVHQMM GRAGRPGLDP YGEAVLIASS HDEVDELFER YVWADPEPVR
     SKLAAEPALR THILATVASG FARSRKGLLE FLEQTLYASQ TDDSGQLERV VDDVLTYLQR
     NDFLEIEAGE LDATSLGHTV SRLYLDPMSA AEIVDGLRDW ERGASDSTSA SGSPADAQAE
     PPANSGFTTA SELAEDADES DADRDPDDIS ALGLYHLVSR TPDMYQLYLR SGDREEYEME
     LFEREEELLG PTPSEFEEGR FEDWLSALKT ARLLEDWATE VDEATITDRY GVGPGDIRGK
     VETAQWLLGA AESLASEVDL DAARAISEAR IRVEHGVREE LVDLAGVRGV GRKRARRLFQ
     AGITDRAQLR DADKAVVLAA LRGRRKTAEN VLENAGHRDP SMEGVEPAPD VSVDLNDGAD
     GDASAESTAN DDQASLGDF