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HELS_METAR
ID   HELS_METAR              Reviewed;         740 AA.
AC   Q0W6L1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   OrderedLocusNames=UNCMA_22030; ORFNames=RCIX575;
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC       involved in repair of stalled replication forks. {ECO:0000255|HAMAP-
CC       Rule:MF_00442}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
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DR   EMBL; AM114193; CAJ35982.1; -; Genomic_DNA.
DR   RefSeq; WP_012036523.1; NC_009464.1.
DR   AlphaFoldDB; Q0W6L1; -.
DR   SMR; Q0W6L1; -.
DR   STRING; 351160.RCIX575; -.
DR   EnsemblBacteria; CAJ35982; CAJ35982; RCIX575.
DR   GeneID; 5144228; -.
DR   KEGG; rci:RCIX575; -.
DR   PATRIC; fig|351160.9.peg.2253; -.
DR   eggNOG; arCOG00553; Archaea.
DR   OMA; MFLNANI; -.
DR   OrthoDB; 9752at2157; -.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00442; Helicase_Hel308; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR022965; Helicase_Hel308.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..740
FT                   /note="ATP-dependent DNA helicase Hel308"
FT                   /id="PRO_1000124587"
FT   DOMAIN          33..204
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   DOMAIN          236..436
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   REGION          716..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           149..152
FT                   /note="DEAH box"
FT   COMPBIAS        723..740
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         28
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
SQ   SEQUENCE   740 AA;  81052 MW;  4073BF8A93A1991E CRC64;
     MKIAELNLPQ ALKDFYTGSG IPELYPPQAE AIRQGLLDGK NLLAAIPTAS GKTLLAEMAM
     LKSIAEGGKA IYIVPLKALA SEKYDRFLEF SKLPIKPDGV KVGIATGDFD SRDEYLGEKD
     IIVATSEKTD SLLRNGASWL SGLSVVVADE VHLIDSPNRG PTLEVTLAKL RKINVNLQIL
     ALSATIGNAK ALAKWMDAAL VQSEWRPTTL KEGVFYGRAI TFKKEKRTVN NAGPDEVNSL
     VADTLEEGGQ CLVFANTRKS SESIAQKVAR SLSKKLQPAE KEQLAKLKQD VLRHAETDTC
     EKLAECVGNG VAFHHAGLKG EHRRIVEDGF RQNILKVIAC TPTLAAGLNL PARRVIIRDY
     KRFDVNYGSV PIPVLEYKQM AGRAGRPRLD PYGEAVLIAK NYDEFGELME NYINADPEHI
     TSKLGTEPAM RAHALSAVAT DFCRSRQDLK AFMDTTFFAY QRGDLSHVID NVLNFLLEEN
     MIIESKGGSL KATDLGSLVS KLYIDPLSAA LIAEGLEKAK KRPDVAEFGL LHLICSTPDV
     KSLYLRRGDY SWIIRYADEH ASDFLSDVPD SYGDDVEFEQ FLAGVKTAAL AEMWINEKSE
     EAITTFFNIG PGDIRNLMET CTWLMHGTAE ISALLGAPAT RTARELAIRI ENGASRELLD
     LITLKGVGRV RARKLYDAGY TSRDKLKAAE IPAIAAIPGI GDKLAVSIMS QLGRKVDHTP
     PETEEQPQVS GQSTLFSFDG
 
 
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