ID   HELS_METVS              Reviewed;         751 AA.
AC   A6UN73;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   OrderedLocusNames=Mevan_0030;
OS   Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148
OS   / SB).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=406327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus vannielii SB.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC       involved in repair of stalled replication forks. {ECO:0000255|HAMAP-
CC       Rule:MF_00442}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
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DR   EMBL; CP000742; ABR53945.1; -; Genomic_DNA.
DR   RefSeq; WP_011971849.1; NC_009634.1.
DR   AlphaFoldDB; A6UN73; -.
DR   SMR; A6UN73; -.
DR   STRING; 406327.Mevan_0030; -.
DR   PRIDE; A6UN73; -.
DR   EnsemblBacteria; ABR53945; ABR53945; Mevan_0030.
DR   GeneID; 5325697; -.
DR   KEGG; mvn:Mevan_0030; -.
DR   eggNOG; arCOG00553; Archaea.
DR   HOGENOM; CLU_006553_3_0_2; -.
DR   OMA; MFLNANI; -.
DR   OrthoDB; 9752at2157; -.
DR   Proteomes; UP000001107; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00442; Helicase_Hel308; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR022965; Helicase_Hel308.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding.
FT   CHAIN           1..751
FT                   /note="ATP-dependent DNA helicase Hel308"
FT                   /id="PRO_1000124584"
FT   DOMAIN          26..196
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   DOMAIN          235..435
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   MOTIF           143..146
FT                   /note="DEAH box"
FT   BINDING         20
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
SQ   SEQUENCE   751 AA;  85591 MW;  8CE0E1589A544761 CRC64;
     MTNVLNLLNE IGIEELRPPQ KKVIEEGLLD KSKNFLICIP TASGKTLIGE MALLNHVLDE
     NYNLTGKKGL FIVPLKALAS EKFDEFQKKY ETYGIKVGMS IGDYDTKEDL SKYNIIITTS
     EKLDSLMRHN IEWIKDLSLA VIDEIHLIGD NERGGTLEVI LTKLKNINAQ IVGLSATVGN
     PEEIANWLNA KLVTDEWRPV ELKKGIYLEN EINYINNQDS QKKSFKAVKS ISRNNLTDLI
     VDSVNEKGSC LIFCNSKRNA VGESKKHNLT KYLSKAELND LNSISEEILS ILETPTETCK
     SLSECIKKGV AFHHAGLTYQ HRKAVEEGFR NKVIKVICCT PTLSAGLNLP CRRAIIRDIR
     RYSQNGLIDI PKLEIHQCIG RAGRPGLDPY GEGIILAKNE KDVEKAFLAL TGPLENIYSK
     LSNQKVLRVH ILGLIATLEI KSTSELINFI KNTFYAHQYG NLHGVLTNVS KVVEFLEKNK
     FIETLDDDFT PKKNRVLELT LDNSNNLVLD SKRRMDTLTN LSFKPTNLGK RVSELYIDPL
     SSEIIIEGLN ELKEKINDMD RSNIDQYIFY IISKATEMRP LLRVKMDEEL ELIQEMDKLK
     ISDYSIENIE AFKNSKMFLD WINETPEEVI LEKYGIEPGI LRYKVDQARW MTYSSKEIAK
     LVKLNNDKIY KALLEMEFRI EYGAKEELIE LLKIKNIGRV RARRLFNIGI KSKMDILKNP
     EKIISTFGDK VGKKILDEFG LKYGQQKLSG F