HELS_PYRHO
ID HELS_PYRHO Reviewed; 715 AA.
AC O59025;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442}; OrderedLocusNames=PH1280;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
CC -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC involved in repair of stalled replication forks. {ECO:0000255|HAMAP-
CC Rule:MF_00442}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00442}.
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DR EMBL; BA000001; BAA30383.1; -; Genomic_DNA.
DR PIR; E71073; E71073.
DR RefSeq; WP_010885366.1; NC_000961.1.
DR AlphaFoldDB; O59025; -.
DR SMR; O59025; -.
DR STRING; 70601.3257700; -.
DR PRIDE; O59025; -.
DR EnsemblBacteria; BAA30383; BAA30383; BAA30383.
DR GeneID; 1443602; -.
DR KEGG; pho:PH1280; -.
DR eggNOG; arCOG00553; Archaea.
DR OMA; MFLNANI; -.
DR OrthoDB; 9752at2157; -.
DR BRENDA; 3.6.4.13; 5244.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00442; Helicase_Hel308; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR022965; Helicase_Hel308.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW Nucleotide-binding.
FT CHAIN 1..715
FT /note="ATP-dependent DNA helicase Hel308"
FT /id="PRO_0000102111"
FT DOMAIN 33..197
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT DOMAIN 229..422
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT MOTIF 1..29
FT /note="Q motif"
FT MOTIF 145..148
FT /note="DEAH box"
FT BINDING 28
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT BINDING 46..53
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
SQ SEQUENCE 715 AA; 82106 MW; F0E2A1AC765C999C CRC64;
MKVEELRIDE RIKEVLKKRG ISELYPPQAE ALTSGILKGE NALIAIPTAS GKTLIAEIAI
VNRLLKEGGK AVYLVPLKAL AEEKFKEFKD WEELGLKVAM ATGDYDSKDE WLGGYDIIIA
TAEKFDSLLR HGSSWIRNVK VLVVDEIHLI GSRDRGATLE FIITQMLNRA QIIGLSATIG
NPEELAEWLN AKLIKSDWRP VKLRRGVFYQ GFVFWEDGKT EKFNSWEELV YDAIKRSKGS
LVFVNMRRKA EKTALELSKK IRNFLTKKEL RELKELAESL EENPTNEKLA KALQGGVAFH
HAGLGREERV LVEENFKKGL IKVVVATPTL SAGINTPAFR VIVRDTWRYS EFGMERIPIL
EIQQMMGRAG RPKYDEVGEA IIVSTTEEPS TVMERYIKGK PEKLFSQLSN ESILRGQILA
LIATFNFSSF REIYDFLERT FYAYQGKDPY TLEDRIRDIV YFLLENEFIE ITLDDEIKAL
PLGIRTAKLY IDPMTAKIFK DTLPKIEKDP NPLGILHVIS LTPDLIPLPY GKKELPMLED
EYYSFKDRLY FELDWEDERK FLRAFKTALV LNAWINEVPE GEIVEKFNVE PGDIYRIVET
AEWLVYSLKE IAKTLEYSQD VINYLETLRV RVKHGIREEL IPLMELPMIG RKRARALYNA
GFRDLESIKN ARPAELLEVE GIGAKIVEAI LKHLGREVKI VQKPRKGTLD YYLHP