ANGE1_HUMAN
ID ANGE1_HUMAN Reviewed; 670 AA.
AC Q9UNK9; B4DWL7; O94859; Q8NCS9;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein angel homolog 1;
GN Name=ANGEL1; Synonyms=KIAA0759;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XI. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:277-286(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 441-670.
RC TISSUE=Mammary tumor;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA34479.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAG63079.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB018302; BAA34479.1; ALT_INIT; mRNA.
DR EMBL; AL137268; CAB70667.2; -; mRNA.
DR EMBL; AF111169; AAD44362.1; -; Genomic_DNA.
DR EMBL; BC028714; AAH28714.1; -; mRNA.
DR EMBL; AK301589; BAG63079.1; ALT_INIT; mRNA.
DR CCDS; CCDS9852.1; -.
DR RefSeq; NP_056120.2; NM_015305.3.
DR AlphaFoldDB; Q9UNK9; -.
DR SMR; Q9UNK9; -.
DR BioGRID; 116938; 61.
DR IntAct; Q9UNK9; 15.
DR MINT; Q9UNK9; -.
DR STRING; 9606.ENSP00000251089; -.
DR iPTMnet; Q9UNK9; -.
DR PhosphoSitePlus; Q9UNK9; -.
DR SwissPalm; Q9UNK9; -.
DR BioMuta; ANGEL1; -.
DR EPD; Q9UNK9; -.
DR jPOST; Q9UNK9; -.
DR MassIVE; Q9UNK9; -.
DR MaxQB; Q9UNK9; -.
DR PaxDb; Q9UNK9; -.
DR PeptideAtlas; Q9UNK9; -.
DR PRIDE; Q9UNK9; -.
DR ProteomicsDB; 85301; -.
DR Antibodypedia; 58; 113 antibodies from 19 providers.
DR DNASU; 23357; -.
DR Ensembl; ENST00000251089.8; ENSP00000251089.3; ENSG00000013523.11.
DR GeneID; 23357; -.
DR KEGG; hsa:23357; -.
DR MANE-Select; ENST00000251089.8; ENSP00000251089.3; NM_015305.4; NP_056120.2.
DR UCSC; uc001xsv.4; human.
DR CTD; 23357; -.
DR GeneCards; ANGEL1; -.
DR HGNC; HGNC:19961; ANGEL1.
DR HPA; ENSG00000013523; Low tissue specificity.
DR MIM; 619537; gene.
DR neXtProt; NX_Q9UNK9; -.
DR OpenTargets; ENSG00000013523; -.
DR PharmGKB; PA134982299; -.
DR VEuPathDB; HostDB:ENSG00000013523; -.
DR eggNOG; KOG2338; Eukaryota.
DR GeneTree; ENSGT00940000159057; -.
DR HOGENOM; CLU_016428_6_0_1; -.
DR InParanoid; Q9UNK9; -.
DR OMA; FCDAACE; -.
DR OrthoDB; 704519at2759; -.
DR PhylomeDB; Q9UNK9; -.
DR TreeFam; TF316126; -.
DR PathwayCommons; Q9UNK9; -.
DR SignaLink; Q9UNK9; -.
DR BioGRID-ORCS; 23357; 46 hits in 1080 CRISPR screens.
DR ChiTaRS; ANGEL1; human.
DR GenomeRNAi; 23357; -.
DR Pharos; Q9UNK9; Tbio.
DR PRO; PR:Q9UNK9; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9UNK9; protein.
DR Bgee; ENSG00000013523; Expressed in right testis and 197 other tissues.
DR ExpressionAtlas; Q9UNK9; baseline and differential.
DR Genevisible; Q9UNK9; HS.
DR GO; GO:0005801; C:cis-Golgi network; IDA:AgBase.
DR GO; GO:0005829; C:cytosol; IDA:AgBase.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:AgBase.
DR GO; GO:0005634; C:nucleus; IDA:AgBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:AgBase.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0008190; F:eukaryotic initiation factor 4E binding; IDA:AgBase.
DR GO; GO:0019904; F:protein domain specific binding; IDA:AgBase.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..670
FT /note="Protein angel homolog 1"
FT /id="PRO_0000218581"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B2RYM0"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B2RYM0"
FT VARIANT 141
FT /note="G -> W (in dbSNP:rs34270005)"
FT /id="VAR_056239"
FT VARIANT 383
FT /note="V -> L (in dbSNP:rs45499197)"
FT /id="VAR_061374"
FT VARIANT 515
FT /note="F -> C (in dbSNP:rs2075773)"
FT /id="VAR_056240"
FT CONFLICT 415
FT /note="D -> G (in Ref. 4; AAH28714)"
FT /evidence="ECO:0000305"
FT CONFLICT 441
FT /note="P -> T (in Ref. 5; BAG63079)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 670 AA; 75276 MW; 3D40E26813E27D83 CRC64;
MIASCLCYLL LPATRLFRAL SDAFFTCRKN VLLANSSSPQ VEGDFAMAPR GPEQEECEGL
LQQWREEGLS QVLSTASEGP LIDKGLAQSS LALLMDNPGE ENAASEDRWS SRQLSDLRAA
ENLDEPFPEM LGEEPLLEVE GVEGSMWAAI PMQSEPQYAD CAALPVGALA TEQWEEDPAV
LAWSIAPEPV PQEEASIWPF EGLGQLQPPA VEIPYHEILW REWEDFSTQP DAQGLKAGDG
PQFQFTLMSY NILAQDLMQQ SSELYLHCHP DILNWNYRFV NLMQEFQHWD PDILCLQEVQ
EDHYWEQLEP SLRMMGFTCF YKRRTGCKTD GCAVCYKPTR FRLLCASPVE YFRPGLELLN
RDNVGLVLLL QPLVPEGLGQ VSVAPLCVAN THILYNPRRG DVKLAQMAIL LAEVDKVARL
SDGSHCPIIL CGDLNSVPDS PLYNFIRDGE LQYHGMPAWK VSGQEDFSHQ LYQRKLQAPL
WPSSLGITDC CQYVTSCHPK RSERRKYGRD FLLRFRFCSI ACQRPVGLVL MEGVTDTKPE
RPAGWAESVL EEDASELEPA FSRTVGTIQH CLHLTSVYTH FLPQRGRPEV TTMPLGLGMT
VDYIFFSAES CENGNRTDHR LYRDGTLKLL GRLSLLSEEI LWAANGLPNP FCSSDHLCLL
ASFGMEVTAP
