ID   HELS_SULAC              Reviewed;         705 AA.
AC   Q4JC00;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442}; OrderedLocusNames=Saci_0263;
OS   Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS   15157 / NCIMB 11770).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=330779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
CC   -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC       involved in repair of stalled replication forks. {ECO:0000255|HAMAP-
CC       Rule:MF_00442}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
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DR   EMBL; CP000077; AAY79679.1; -; Genomic_DNA.
DR   RefSeq; WP_011277181.1; NC_007181.1.
DR   AlphaFoldDB; Q4JC00; -.
DR   SMR; Q4JC00; -.
DR   STRING; 330779.Saci_0263; -.
DR   EnsemblBacteria; AAY79679; AAY79679; Saci_0263.
DR   GeneID; 3474820; -.
DR   KEGG; sai:Saci_0263; -.
DR   PATRIC; fig|330779.12.peg.259; -.
DR   eggNOG; arCOG00553; Archaea.
DR   HOGENOM; CLU_006553_3_0_2; -.
DR   OMA; MFLNANI; -.
DR   Proteomes; UP000001018; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00442; Helicase_Hel308; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR022965; Helicase_Hel308.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..705
FT                   /note="ATP-dependent DNA helicase Hel308"
FT                   /id="PRO_1000124586"
FT   DOMAIN          36..200
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   DOMAIN          236..430
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   MOTIF           148..151
FT                   /note="DEAH box"
FT   BINDING         31
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   BINDING         49..56
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
SQ   SEQUENCE   705 AA;  79452 MW;  79D88D2ACD086DA4 CRC64;
     MEEITVEDLP VDSKVKDIIK SRGIKKLNPP QTEAVKKGLI EDKRLLITTP TASGKTLMAE
     LGMISHLLNK GGKAIYVTPL RALTSEKYST FKDWEKLGFK VGVTSGDYDT DDPWLRNFDI
     IVTTYEKLDS LWRHSAEWLK DIDYFVLDEF HYMNDGDRGP VVEGVAVRAK RQGTILALSA
     TIGNAKDVAK WLNADIVATN WRPVPLKEGV MYSEGKKGHI ILYSDGTTNK LKGDDPIIAY
     TLDILSKGGQ VIVFRSSRKY AETTAMKISQ YMNFVKLDDK KLLETAERIK EVEDAGSNEK
     EVLYNLIVRG VAFHHAGLSK GLRDIIEASF RERIIKVITA TPTLAAGVNL PARAVVIGDI
     YRFNRKIVGF TEMISTMEYR QMSGRAGRPG YDNHGEAIIL VRSKVEVDKV IDKYLHSDIE
     PIESKLGAEG PFFSFVLSLI ASEGEITEDR LKDYVEDTML SKQLVRKYYN NAIDWLSKNE
     FIKSNDDRLQ LTKFGRRVSD LYLNPFTAVT IKNYLERAES PCDIAYFHLI AYTPDGPLVS
     VGRNEEDALL DNLDCELIID EPDDELEFSN YISALKVAFI LKDWIEEVDE DTILSKYGIG
     SGDLRAIIDT MEWLTYGAFH VSSILDLNQH TSVLEKLHKR IADGVKEELL ELVRVPGIGR
     ARARLLFNQG IKRPEDIVMK PERVKSLLGQ NLGEKIVKEA ARIIA