ID   HELS_THEAC              Reviewed;         674 AA.
AC   Q9HJX7;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442}; OrderedLocusNames=Ta0835;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC       involved in repair of stalled replication forks. {ECO:0000255|HAMAP-
CC       Rule:MF_00442}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
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DR   EMBL; AL445065; CAC11964.1; -; Genomic_DNA.
DR   RefSeq; WP_010901246.1; NC_002578.1.
DR   AlphaFoldDB; Q9HJX7; -.
DR   SMR; Q9HJX7; -.
DR   STRING; 273075.Ta0835; -.
DR   EnsemblBacteria; CAC11964; CAC11964; CAC11964.
DR   GeneID; 1456378; -.
DR   KEGG; tac:Ta0835; -.
DR   eggNOG; arCOG00553; Archaea.
DR   HOGENOM; CLU_006553_3_0_2; -.
DR   OMA; MFLNANI; -.
DR   OrthoDB; 9752at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00442; Helicase_Hel308; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR022965; Helicase_Hel308.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..674
FT                   /note="ATP-dependent DNA helicase Hel308"
FT                   /id="PRO_0000102114"
FT   DOMAIN          31..197
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   DOMAIN          224..411
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   MOTIF           142..145
FT                   /note="DEAH box"
FT   BINDING         27
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   BINDING         44..51
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
SQ   SEQUENCE   674 AA;  75754 MW;  A1B8A913DE2CCC68 CRC64;
     MKISELGYDR AFLQLFDGND FQLYDHQRMA IEQIRKGRNV VVSVPTAAGK TLIAYSAIYE
     TFQRNLKSIY IVPLRSLAME KFSELSRLRD LGLKVKMSIG DYDDSPDFIK RYDAVILTSE
     KADSLLHHDP YILNDVGLLV LDEIHTIGDE SRGPTLETVA SIARYVNPDV RILALSATVS
     NAMELASWLD ASLIKSDFRP VPLKTGILYR DQLYLDGKRR SGVSINQIIR ETVEDNGQVL
     MFVSSRKKAE DTARDLAQIF GSDANIKISS DETNVYDDML NEILPRGVAF HHAGLSNDQR
     AFIEREFRAR RIKVIVATPT LAAGVNLPAR LVIVRDITRW GSDGISYLTN MEIKQMIGRA
     GRPGYDQYGI GLIYVSSQSS YEAAKDYLST DPEPVVSYLG NEAKVRFNTL AAISMGLARS
     PSDIMKFYET TLFFSQNGKD LLEEKISASL KFLEKNGFIK QSPDLRTTQL GKVTSDLYID
     PESALRLVDF FDGPADVDHA IYYISLCREI VPFNIKDDYS AMEFLDDIGL IDGDIDAAKT
     AIVLRDWISE ASYKYLYDKY GIAPGDMQAR ISMADWLSYS LAKLSSIYKP EVRRMLEILN
     LRIKEGIRED ILQLVLIPGV GRVRARRLYD AGLRSIEDVA SASPDRIKAI YGFSDTLANA
     IIRRARTIAS KEVR