ID   HELS_THEVO              Reviewed;         674 AA.
AC   Q97AI2;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442}; OrderedLocusNames=TV0828;
GN   ORFNames=TVG0843689;
OS   Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS   15438 / GSS1).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX   PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA   Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA   Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA   Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT   "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT   Thermoplasma volcanium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC   -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC       involved in repair of stalled replication forks. {ECO:0000255|HAMAP-
CC       Rule:MF_00442}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
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DR   EMBL; BA000011; BAB59970.1; -; Genomic_DNA.
DR   RefSeq; WP_010917072.1; NC_002689.2.
DR   AlphaFoldDB; Q97AI2; -.
DR   SMR; Q97AI2; -.
DR   STRING; 273116.14325044; -.
DR   EnsemblBacteria; BAB59970; BAB59970; BAB59970.
DR   GeneID; 1441920; -.
DR   KEGG; tvo:TVG0843689; -.
DR   eggNOG; arCOG00553; Archaea.
DR   HOGENOM; CLU_006553_3_0_2; -.
DR   OMA; MFLNANI; -.
DR   OrthoDB; 9752at2157; -.
DR   PhylomeDB; Q97AI2; -.
DR   Proteomes; UP000001017; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00442; Helicase_Hel308; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR022965; Helicase_Hel308.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding.
FT   CHAIN           1..674
FT                   /note="ATP-dependent DNA helicase Hel308"
FT                   /id="PRO_0000102115"
FT   DOMAIN          31..197
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   DOMAIN          224..411
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   MOTIF           142..145
FT                   /note="DEAH box"
FT   BINDING         27
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
FT   BINDING         44..51
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00442"
SQ   SEQUENCE   674 AA;  76594 MW;  B008EDD1F63FEC84 CRC64;
     MKISDLGYDE SFLDLFEGND FELYDHQRMA IEQFRKGKNI MVSVPTAAGK TLIAYSAIYE
     TFKKKLKSIY IVPLRSLAME KYEELSRLRE LGMRVKLSIG NYDDTPDFIK RYDVVILTSE
     KADSLMHHDP YMMEEVGLMV IDEIHMIGDE YRGPTLETVI TTARYVNPET RIIALSATVS
     NASEIAEWLN ASLIKSSFRP VPLKVGILYR NRLFLDGDAR SDVDINLLVK ETVDDGGQVL
     IFVSSRKRAE DMAKNLSQLF DPINDLKVSS EDANVYDDLL NEMLPHGVSF HHAGLSNEQR
     SFIEKAFRHR KLKVIVATPT LAAGVNLPAR LVIVKDVTRY GDLGITYLSN MEVKQMIGRA
     GRPGYDQYGI GIIYAASANS YQVVKEYISE EPEPVDSYIG KPEKVRFNTL AAIAMGLATS
     QVEMEEFYRS TFYYAQNGED EIPNRINESI KFLKENGFIK EKDSLRATEF GKMISNLYID
     PESAIILKKY FDDNDDIDTA LYYISLCREI APINMQDDYA AMEFLESIGH IDGDIEAAKT
     ALVLREWISE ASTRRIFEMY GVAPGDLQAR VNNADWISYS LAHLASIFKP ERRRKLEILN
     MRIKEGIREE LMDLVLIPAI GRVRARRLYE AGIHNVQELA FSDPSRIKML YGFSDTLANA
     VVKRAKAIVS ERIR