ID   HELT_DANRE              Reviewed;         270 AA.
AC   Q6QB00; Q568X6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Hairy and enhancer of split-related protein helt;
DE   AltName: Full=HES/HEY-like transcription factor;
GN   Name=helt; ORFNames=zgc:109704;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gajewski M., Sieger D., Tautz D.;
RT   "Her/Hey-related shows highly restricted expression in the developing brain
RT   of the zebrafish embryo.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor which binds preferentially to the
CC       canonical E box sequence 5'-CACGCG-3'. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380,
CC       ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- SIMILARITY: Belongs to the HEY family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY549496; AAS55698.1; -; mRNA.
DR   EMBL; BC092667; AAH92667.2; -; mRNA.
DR   RefSeq; NP_996948.1; NM_207065.2.
DR   AlphaFoldDB; Q6QB00; -.
DR   SMR; Q6QB00; -.
DR   STRING; 7955.ENSDARP00000073348; -.
DR   PaxDb; Q6QB00; -.
DR   Ensembl; ENSDART00000078889; ENSDARP00000073348; ENSDARG00000056400.
DR   GeneID; 404275; -.
DR   KEGG; dre:404275; -.
DR   CTD; 391723; -.
DR   ZFIN; ZDB-GENE-040824-6; helt.
DR   eggNOG; KOG4304; Eukaryota.
DR   GeneTree; ENSGT00940000160388; -.
DR   HOGENOM; CLU_084227_0_0_1; -.
DR   InParanoid; Q6QB00; -.
DR   OMA; FAWPHGA; -.
DR   OrthoDB; 1054305at2759; -.
DR   PhylomeDB; Q6QB00; -.
DR   TreeFam; TF323617; -.
DR   PRO; PR:Q6QB00; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000056400; Expressed in dorsal thalamus and 11 other tissues.
DR   ExpressionAtlas; Q6QB00; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   Pfam; PF07527; Hairy_orange; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..270
FT                   /note="Hairy and enhancer of split-related protein helt"
FT                   /id="PRO_0000349385"
FT   DOMAIN          59..114
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   DOMAIN          136..171
FT                   /note="Orange"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  30861 MW;  A9D484CAB96B6018 CRC64;
     MNARALYKRP PPVSSSQSEA SGKRRTRTLD ALGFDNYIIC NYRLVFYEMM ASKMKDRKKT
     PVSHKVIEKR RRDRINRCLN ELGKTVPMAL AKQNSGKLEK AEILEMTVQY LRALHSADFP
     RGREKGELLT EFANYFHYGY HECMKNLVHY LTTVERMETK DTKYARILAF LQSKVVTEPV
     FGSLGTISPD PTDLLCQLEY QSPSPTESVF QQSPPGHFSW HSSTRSPTLA YPAMSQHSGY
     LSPVQGLDHH YMNFIGHNAF SLHNAQHAAL