ANGE1_MOUSE
ID ANGE1_MOUSE Reviewed; 667 AA.
AC Q8VCU0; Q5DU16;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein angel homolog 1 {ECO:0000312|MGI:MGI:1915987};
GN Name=Angel1 {ECO:0000312|MGI:MGI:1915987};
GN Synonyms=Kiaa0759 {ECO:0000312|EMBL:BAD90417.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:AAH19148.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH19148.1};
RC TISSUE=Liver {ECO:0000312|EMBL:AAH19148.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:BAD90417.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 269-434.
RC TISSUE=Brain {ECO:0000312|EMBL:BAD90417.1};
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000255}.
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DR EMBL; AC102689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019148; AAH19148.1; -; mRNA.
DR EMBL; AK220354; BAD90417.1; -; mRNA.
DR CCDS; CCDS26067.1; -.
DR RefSeq; NP_653107.2; NM_144524.2.
DR AlphaFoldDB; Q8VCU0; -.
DR SMR; Q8VCU0; -.
DR BioGRID; 213025; 1.
DR IntAct; Q8VCU0; 1.
DR MINT; Q8VCU0; -.
DR STRING; 10090.ENSMUSP00000021682; -.
DR PhosphoSitePlus; Q8VCU0; -.
DR CPTAC; non-CPTAC-3400; -.
DR EPD; Q8VCU0; -.
DR PaxDb; Q8VCU0; -.
DR PRIDE; Q8VCU0; -.
DR ProteomicsDB; 282096; -.
DR Antibodypedia; 58; 113 antibodies from 19 providers.
DR DNASU; 68737; -.
DR Ensembl; ENSMUST00000021682; ENSMUSP00000021682; ENSMUSG00000021257.
DR GeneID; 68737; -.
DR KEGG; mmu:68737; -.
DR UCSC; uc011ypj.1; mouse.
DR CTD; 23357; -.
DR MGI; MGI:1915987; Angel1.
DR VEuPathDB; HostDB:ENSMUSG00000021257; -.
DR eggNOG; KOG2338; Eukaryota.
DR GeneTree; ENSGT00940000159057; -.
DR HOGENOM; CLU_016428_6_0_1; -.
DR InParanoid; Q8VCU0; -.
DR OMA; FCDAACE; -.
DR OrthoDB; 704519at2759; -.
DR PhylomeDB; Q8VCU0; -.
DR TreeFam; TF316126; -.
DR BioGRID-ORCS; 68737; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Angel1; mouse.
DR PRO; PR:Q8VCU0; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8VCU0; protein.
DR Bgee; ENSMUSG00000021257; Expressed in spermatid and 186 other tissues.
DR Genevisible; Q8VCU0; MM.
DR GO; GO:0005801; C:cis-Golgi network; ISS:AgBase.
DR GO; GO:0005829; C:cytosol; ISS:AgBase.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:AgBase.
DR GO; GO:0005634; C:nucleus; ISS:AgBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:AgBase.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0008190; F:eukaryotic initiation factor 4E binding; ISS:AgBase.
DR GO; GO:0019904; F:protein domain specific binding; ISS:AgBase.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..667
FT /note="Protein angel homolog 1"
FT /id="PRO_0000356223"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B2RYM0"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B2RYM0"
FT CONFLICT 124
FT /note="N -> D (in Ref. 2; AAH19148)"
FT /evidence="ECO:0000305"
FT CONFLICT 430..434
FT /note="DLNSV -> AATQL (in Ref. 3; BAD90417)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 667 AA; 75254 MW; 7D78928D61894A7A CRC64;
MIASCLYYLL LPAARLFRFL SDAFFTCRKN ALLAKSSSPQ VEGNFAMAPR GPDQEECEGL
LQQWREEGWN QTPSTASEGP LADKGLAESS LALLMDNSGE QDAASEDKWS SRQLSDLRAA
ENLNQPFPEV LGEEPLAEVE GPLWAAVPVQ TGPQYADCAV LPMGAMAAEQ WEEDPAMVAW
SIAPEPMPQE ETSMWPFEGL EQLQPPPMEI PYHEILWREW EDFSTQPDAQ GLEAGDGPQF
QFTLMSYNIL AQDLMQQSSE LYLHCHPDIL NWNYRFANLM QEFQHWDPDI LCLQEVQEDH
YWEQLEPSLR MMGFTCFYKR RTGCKTDGCA VCYKPTRFRL LCASPVEYFR PGLELLNRDN
VGLVLLLQPL VPEGLGQVSV APLCVANTHV LYNPRRGDVK LAQMAILLAE VDKVARLSDG
SHCPIILCGD LNSVPDSPLY NFIRDGELQY NGMPAWKVSG QEDFSHQLYQ RKLQAPLWPS
SLGITDCCQY VTSCHPKRSE RLKYGRDFLL RFRFCDLACQ RPVGLVLMEG VTDTKPDRPA
GWAECIFEEE ISELEPVFPR TIGTIQHCLH LTSVYTHFLP QHGCPEVTTM PLGLGMTVDY
IFFSAESCEN ENRTDHRLDR DGTLKLLGRL SLLSEEILWA ANGLPNPFYS SDHLCLLASF
GMEVTAP
