ID   HELX_METJA              Reviewed;         841 AA.
AC   Q57742;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Uncharacterized ATP-dependent helicase MJ0294;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=MJ0294;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: Belongs to the helicase family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98279.1; -; Genomic_DNA.
DR   PIR; G64336; G64336.
DR   RefSeq; WP_010869792.1; NC_000909.1.
DR   AlphaFoldDB; Q57742; -.
DR   SMR; Q57742; -.
DR   STRING; 243232.MJ_0294; -.
DR   PRIDE; Q57742; -.
DR   EnsemblBacteria; AAB98279; AAB98279; MJ_0294.
DR   GeneID; 1451149; -.
DR   KEGG; mja:MJ_0294; -.
DR   eggNOG; arCOG00557; Archaea.
DR   HOGENOM; CLU_002025_0_0_2; -.
DR   InParanoid; Q57742; -.
DR   OMA; VVDEWHE; -.
DR   OrthoDB; 995at2157; -.
DR   PhylomeDB; Q57742; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR013701; DEAD/DEAH_assoc.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR017170; Lhr-like_ATP-dep_RNA_helic_prd.
DR   InterPro; IPR045628; Lhr_WH_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08494; DEAD_assoc; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF19306; Lhr_WH; 1.
DR   PIRSF; PIRSF037307; Lhr-like_helic_prd; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..841
FT                   /note="Uncharacterized ATP-dependent helicase MJ0294"
FT                   /id="PRO_0000102196"
FT   DOMAIN          43..234
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          266..416
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           181..184
FT                   /note="DEVH box"
FT   BINDING         56..63
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   841 AA;  97268 MW;  4C28AA8AA9459505 CRC64;
     MGRVEYLKKE YSDEEIYEIL EKPVKEWFKR KYKTFTPPQR YAIKEIHEGK NVLICSPTGS
     GKTLSAFLAG INELIKLSME NKLEDRIYIL YVSPLRALNN DIERNLKEPL KEIYDVAKEI
     GIELDEIRVA VRTSDTTSSQ KQRMLKKPPH ILITTPESLA IALNSPKFSQ LLSGIKYVIV
     DEIHALTNKR GVHLSLSLER LNRIANFIRI GLSATIHPLT EVAKFLVGNG RDCYIVDVSY
     KKEIEIKVIS PVDDFIYTPS EEISKRLYNL LKKLIEEHKT TLIFTNTRSA TERVAFYLKQ
     LGVEKVETHH SSLSREHRLE VEEKLKKGEI RVCISSTSLE LGVDIGSIDL VILLGSPKSV
     SRALQRIGRS GHRLHEKSKG IIIPFDRDDL VENVVLAYDA KIGKIDRIHI PKNCLDVLAQ
     HLVGMALEKV WDVDEAYNLI KKAYPYKDLS KKDFLDVLNY LAGGIEEKNV YAKIWLKDNK
     FGKRGKSVRA IYYMNVGTIP DETAVDVIAD GKYVGEVEEE FAEKLMKGDI FVLGGKTYKY
     LGGRGNKIRV KEVFDEKPTI PAWFSEQLPL AYDLALDIEK FRKEVLSSDI EEIREKYDID
     EKTAKAIKNY MDEQNKFAIV PDDEKVLIEN FDEEKRRYYI FHFVAGRRAN EALARAFANY
     ISKIKKCNVR ISVNDYGFAL ILPKNRKIKR ADITELFNLD VVKNVKESIE RSEILKRRFR
     HVATRGFMIL RRYMNRKISV DRQQFNAEML LKYCKEVNHP LYRETLREIL EDSLDIDNAL
     DYFEKIKRRK IYYLELPSPS PFAFNLVVSA SSDVIFMEDK KKMIAELHKK VMEFISMKGK
     K