ID   HELX_METTH              Reviewed;         862 AA.
AC   O27830;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Uncharacterized ATP-dependent helicase MTH_1802;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=MTH_1802;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- SIMILARITY: Belongs to the helicase family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB86268.1; -; Genomic_DNA.
DR   PIR; H69107; H69107.
DR   RefSeq; WP_010877404.1; NC_000916.1.
DR   AlphaFoldDB; O27830; -.
DR   SMR; O27830; -.
DR   STRING; 187420.MTH_1802; -.
DR   EnsemblBacteria; AAB86268; AAB86268; MTH_1802.
DR   GeneID; 1470887; -.
DR   KEGG; mth:MTH_1802; -.
DR   PATRIC; fig|187420.15.peg.1756; -.
DR   HOGENOM; CLU_002025_0_0_2; -.
DR   OMA; VVDEWHE; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013701; DEAD/DEAH_assoc.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR017170; Lhr-like_ATP-dep_RNA_helic_prd.
DR   InterPro; IPR045628; Lhr_WH_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08494; DEAD_assoc; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF19306; Lhr_WH; 1.
DR   PIRSF; PIRSF037307; Lhr-like_helic_prd; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..862
FT                   /note="Uncharacterized ATP-dependent helicase MTH_1802"
FT                   /id="PRO_0000102197"
FT   DOMAIN          41..233
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          269..424
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           178..181
FT                   /note="DEIH box"
FT   BINDING         54..61
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   862 AA;  99080 MW;  6FD57905F533AAC9 CRC64;
     MIKKQERMYT SGEIHSILHP WVSEWFRRTF DDFTEAQRYA IMDIHRGRNV LVSSPTGSGK
     TLTAFLSIIS ELTRLADDGE LEDSVYCIYI SPLKALDNDI ERNLEEPLSA IRDIAAGEGR
     DLEIRKAVRT GDTTSYERSR MLKKPPHILI TTPETLSILL VAPKFREKLS TVRYVIVDEI
     HSLADNKRGV HLSLSLERLQ HLVGDFTRIG LSATVHPLER VARFLVGYSY GSERECLIVD
     VSYLKELDID LICPVDDIVA ADPEEIGNAL YDILHDLIED HRTTLIFTNT RSGTESVVYN
     LKSRFPESYS DSNIMAHHSS LSREIRLETE EKLKRGELKA VVSSTSLELG IDIGYIDLVV
     LLSSPKSVSR ALQRIGRSGH QLHQRSKGRI VVVDRDDLVE CSLILKNALE GKIDSIKVPE
     NCLDVLAQHI YGMAIENPWD IDHALAVIRN SYCYRNLSRE DYLSVLSYLA GEYVELEERY
     VYAKIWVDYD KNQFGKRGKL ARMLYSTNIG TIPDRSAAVV KCGGKVVGRI EEDFMEKLRK
     GDTFVLGGRI YRFNYARGMT VNVTPASGPP TIPSWFSEQL PLSFDLALDI QRFRDIMDGK
     FQYGRSRDEI MEFIMSYLHV DERAASSIYE YFREQYLYAG IPSIRRMLVE YYTGFGGRKF
     IVFHSLFGRR VNDAISRAVA YVIARRYRRD VMISVSDNGF YLSSEGKMGG LEAFRELEPE
     NLRNVLKKAL DRTETLASRF RHCAGRALMI LRRYRGEEKS VGRQQVRGKI LLKFVSELDD
     KFPILEEARR EVMEDYMDIE NAIRVLEWIR DGDMEIKQIN TRIPSPFAFN LVAQGYLDVL
     KYEDRIEFIR RMHQAIIDEI KR