ID   HELY_MYCLE              Reviewed;         920 AA.
AC   Q9ZBD8;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Probable helicase HelY;
DE            EC=3.6.4.-;
GN   Name=helY; OrderedLocusNames=ML1333; ORFNames=MLCB2533.29;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL035310; CAA22943.1; -; Genomic_DNA.
DR   EMBL; AL583921; CAC31714.1; -; Genomic_DNA.
DR   PIR; G87075; G87075.
DR   RefSeq; NP_301957.1; NC_002677.1.
DR   RefSeq; WP_010908278.1; NC_002677.1.
DR   AlphaFoldDB; Q9ZBD8; -.
DR   SMR; Q9ZBD8; -.
DR   STRING; 272631.ML1333; -.
DR   PRIDE; Q9ZBD8; -.
DR   EnsemblBacteria; CAC31714; CAC31714; CAC31714.
DR   KEGG; mle:ML1333; -.
DR   PATRIC; fig|272631.5.peg.2453; -.
DR   Leproma; ML1333; -.
DR   eggNOG; COG4581; Bacteria.
DR   HOGENOM; CLU_002902_4_1_11; -.
DR   OMA; ECHYMND; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012961; Ski2_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..920
FT                   /note="Probable helicase HelY"
FT                   /id="PRO_0000102101"
FT   DOMAIN          26..184
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          265..469
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           132..135
FT                   /note="DEVH box"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   920 AA;  100864 MW;  E55FF69E8750A4B4 CRC64;
     MTDLAELARF TAELPFSLDD FQQRACAALE RGHGVLVCAP TGAGKTVVGE FAVHLALAAG
     GKCFYTTPLK ALSNQKYTDL TARYGRNRIG LLTGDQSVNG DSPVVVMTTE VLRNMLYADS
     FALQGLSHVV MDEVHFIADR MRGPVWEEVI LHLPDDVRMV SLSATVSNAE EFGGWVQTVR
     GDTTVVVDEH RPVPLWQHVL VGKRLFDLFD YDSNVDQSPV NPNLLRHIAH CREADRMSDW
     RNPRRRAGRG SGVRPRFYRS LARPEVIAIL DAEGLLPAIT FVFSRFGCDA AVQQCLRSPL
     RLTSEEERAQ IAEVIDHRCG DLADADLAVL GYYEWREGLL RGLAAHHAGM LPAFRHAVEE
     LFTAGLVKAV FATETLALGI NMPARTVVLE RLVKFNGKQH VPLTPGEYTQ LTGRAGRRGI
     DVEGHAVVIW HPSEDTSGPS AVAGLASART FPLRSSFVPS YNMTINLVHW MSPERAHALL
     EQSFAQYQAD RSVVGLVRGI ERCTQVLGDI SSELGGPDAP ILEYARLRAR IAEMERAQSF
     VFRLQRKQAA NDVLAALRRG DIITITHGRH GGLAVVLESA RDSSNPRPLV LTEHRWAGRI
     SSADYMGAAA PVGSMTLPKR VEHRQQRVRR DLASALRSAA TRLSVPDIGD GVDGDKIGFN
     DGVLHDPELA SLRAQLRRHR SNNAPGLDTQ LQQAERYLRI ERYNAQLQRK VAAATNSLAR
     TFDRIVGLLI ERDFIRGPAD DPQVTDDGRL LARIYSESDL LVAECLRTGA WAGLRPAELA
     AVVSAVLYET RGDDGPGGPV DAEAPTPRLR QALQHTSRLS ATLRADEQRH RIALSREPDD
     GFVGVIYCWA RTGDLAAVLA AADASGNGAP LSAGDFVRWC RQVLDLLDQL RNAAPEPDLR
     ATAKRAINDV RRGVVAVDAG