ID   HELY_MYCTO              Reviewed;         906 AA.
AC   P9WMR0; L0T8N1; Q10701;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Probable helicase HelY;
DE            EC=3.6.4.-;
GN   Name=helY; OrderedLocusNames=MT2153;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK46434.1; -; Genomic_DNA.
DR   PIR; G70767; G70767.
DR   RefSeq; WP_003899167.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMR0; -.
DR   SMR; P9WMR0; -.
DR   EnsemblBacteria; AAK46434; AAK46434; MT2153.
DR   KEGG; mtc:MT2153; -.
DR   PATRIC; fig|83331.31.peg.2322; -.
DR   HOGENOM; CLU_002902_4_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012961; Ski2_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..906
FT                   /note="Probable helicase HelY"
FT                   /id="PRO_0000427260"
FT   DOMAIN          26..184
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          259..463
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           132..135
FT                   /note="DEVH box"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   906 AA;  99606 MW;  CC0A34A9495AE568 CRC64;
     MTELAELDRF TAELPFSLDD FQQRACSALE RGHGVLVCAP TGAGKTVVGE FAVHLALAAG
     SKCFYTTPLK ALSNQKHTDL TARYGRDQIG LLTGDLSVNG NAPVVVMTTE VLRNMLYADS
     PALQGLSYVV MDEVHFLADR MRGPVWEEVI LQLPDDVRVV SLSATVSNAE EFGGWIQTVR
     GDTTVVVDEH RPVPLWQHVL VGKRMFDLFD YRIGEAEGQP QVNRELLRHI AHRREADRMA
     DWQPRRRGSG RPGFYRPPGR PEVIAKLDAE GLLPAITFVF SRAGCDAAVT QCLRSPLRLT
     SEEERARIAE VIDHRCGDLA DSDLAVLGYY EWREGLLRGL AAHHAGMLPA FRHTVEELFT
     AGLVKAVFAT ETLALGINMP ARTVVLERLV KFNGEQHMPL TPGEYTQLTG RAGRRGIDVE
     GHAVVIWHPE IEPSEVAGLA STRTFPLRSS FAPSYNMTIN LVHRMGPQQA HRLLEQSFAQ
     YQADRSVVGL VRGIERGNRI LGEIAAELGG SDAPILEYAR LRARVSELER AQARASRLQR
     RQAATDALAA LRRGDIITIT HGRRGGLAVV LESARDRDDP RPLVLTEHRW AGRISSADYS
     GTTPVGSMTL PKRVEHRQPR VRRDLASALR SAAAGLVIPA ARRVSEAGGF HDPELESSRE
     QLRRHPVHTS PGLEDQIRQA ERYLRIERDN AQLERKVAAA TNSLARTFDR FVGLLTEREF
     IDGPATDPVV TDDGRLLARI YSESDLLVAE CLRTGAWEGL KPAELAGVVS AVVYETRGGD
     GQGAPFGADV PTPRLRQALT QTSRLSTTLR ADEQAHRITP SREPDDGFVR VIYRWSRTGD
     LAAALAAADV NGSGSPLLAG DFVRWCRQVL DLLDQVRNAA PNPELRATAK RAIGDIRRGV
     VAVDAG