ID   ANGE1_RAT               Reviewed;         667 AA.
AC   B2RYM0;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein angel homolog 1 {ECO:0000312|RGD:1306238};
GN   Name=Angel1 {ECO:0000312|EMBL:AAI66827.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000269|PubMed:15057822};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAI66827.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 472-667.
RC   STRAIN=Brown Norway/NHsdMcwi {ECO:0000312|EMBL:AAI66827.1};
RC   TISSUE=Embryonic liver {ECO:0000312|EMBL:AAI66827.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-105, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000255}.
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DR   EMBL; AABR03048643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03049665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC166827; AAI66827.1; -; mRNA.
DR   RefSeq; NP_001102187.1; NM_001108717.1.
DR   AlphaFoldDB; B2RYM0; -.
DR   SMR; B2RYM0; -.
DR   STRING; 10116.ENSRNOP00000014635; -.
DR   iPTMnet; B2RYM0; -.
DR   PhosphoSitePlus; B2RYM0; -.
DR   PaxDb; B2RYM0; -.
DR   PeptideAtlas; B2RYM0; -.
DR   Ensembl; ENSRNOT00000014635; ENSRNOP00000014635; ENSRNOG00000010567.
DR   GeneID; 362765; -.
DR   KEGG; rno:362765; -.
DR   UCSC; RGD:1306238; rat.
DR   CTD; 23357; -.
DR   RGD; 1306238; Angel1.
DR   eggNOG; KOG2338; Eukaryota.
DR   GeneTree; ENSGT00940000159057; -.
DR   HOGENOM; CLU_016428_6_0_1; -.
DR   InParanoid; B2RYM0; -.
DR   OrthoDB; 704519at2759; -.
DR   PhylomeDB; B2RYM0; -.
DR   TreeFam; TF316126; -.
DR   PRO; PR:B2RYM0; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000010567; Expressed in testis and 18 other tissues.
DR   ExpressionAtlas; B2RYM0; baseline and differential.
DR   Genevisible; B2RYM0; RN.
DR   GO; GO:0005801; C:cis-Golgi network; ISS:AgBase.
DR   GO; GO:0005829; C:cytosol; ISS:AgBase.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:AgBase.
DR   GO; GO:0005634; C:nucleus; ISS:AgBase.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:AgBase.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0008190; F:eukaryotic initiation factor 4E binding; ISS:AgBase.
DR   GO; GO:0019904; F:protein domain specific binding; ISS:AgBase.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..667
FT                   /note="Protein angel homolog 1"
FT                   /id="PRO_0000356224"
FT   MOD_RES         77
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         105
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   667 AA;  75342 MW;  FA6A520750D5D2E7 CRC64;
     MIASCLYYLL LPAARLFRFL SDAFFTCRKN ALLAKSSSPQ VEGNFAMAPR GPDQEECEGL
     LQQWREEGWN QTLSTASEGP LADKGLAESS LALLMDNSGE QDTASEDKWS SRQLSDLRAA
     DNLDQPFPEV LGEEPLAEDE GPLWAAVPVQ TGPQYADCAV LPMGAMAAEQ WEEDPAMVAW
     SIAPEPMPQE ETSMWPFEGL EQLQPPPMEI PYHEILWREW EDFSTQPDAQ GLEAGDGPQF
     QFTLMSYNIL AQDLMQQSSE LYLHCHPDIL NWNYRFANLM QEFQHWDPDI LCLQEVQEDH
     YWEQLEPSLR MMGFTCFYKR RTGCKTDGCA VCYKPTRFRL LCASPVEYFR PGLELLNRDN
     VGLVLLLQPL VPEGLGQVSV APLCVANTHV LYNPRRGDVK LAQMAILLAE VDKVARLSDG
     SHCPIILCGD LNSVPDSPLY NFIRDGELQY NGMPAWKVSG QEDFSHQLYQ RKLQAPLWPS
     SLGITDCCQY VTSCHPKRSE RLKYGRDFLL RFRFCDLACQ RPVGLVLMEG VTDTKPDRPA
     GWAECIFEEE ISELEPVFPR TIGTIQHCLH LTSVYTHFLP QHGRPEVTTM PLGLGMTVDY
     IFFSAESCEN ENRSDHRLDR DGTLKLLGRL SLLSEEILWA ANGLPNPFYS SDHLCLLASF
     GMEVTAP