ID   ANGE2_DANRE             Reviewed;         569 AA.
AC   Q5RGT6; A0AUR1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Protein angel homolog 2;
GN   Name=angel2; ORFNames=si:ch211-181h6.2, zgc:153829;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000305}.
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DR   EMBL; BX649591; CAI11673.1; -; Genomic_DNA.
DR   EMBL; BC124747; AAI24748.1; -; mRNA.
DR   RefSeq; NP_001025131.1; NM_001029960.1.
DR   AlphaFoldDB; Q5RGT6; -.
DR   SMR; Q5RGT6; -.
DR   STRING; 7955.ENSDARP00000033311; -.
DR   PaxDb; Q5RGT6; -.
DR   PRIDE; Q5RGT6; -.
DR   Ensembl; ENSDART00000036371; ENSDARP00000033311; ENSDARG00000016743.
DR   GeneID; 562704; -.
DR   KEGG; dre:562704; -.
DR   CTD; 90806; -.
DR   ZFIN; ZDB-GENE-030131-6498; angel2.
DR   eggNOG; KOG2338; Eukaryota.
DR   GeneTree; ENSGT00940000157391; -.
DR   HOGENOM; CLU_016428_0_2_1; -.
DR   InParanoid; Q5RGT6; -.
DR   OMA; WEYFCQQ; -.
DR   OrthoDB; 724242at2759; -.
DR   PhylomeDB; Q5RGT6; -.
DR   TreeFam; TF316126; -.
DR   PRO; PR:Q5RGT6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000016743; Expressed in early embryo and 28 other tissues.
DR   ExpressionAtlas; Q5RGT6; baseline and differential.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IBA:GO_Central.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..569
FT                   /note="Protein angel homolog 2"
FT                   /id="PRO_0000305082"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        162
FT                   /note="A -> P (in Ref. 2; AAI24748)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        425
FT                   /note="T -> N (in Ref. 2; AAI24748)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        537
FT                   /note="K -> E (in Ref. 2; AAI24748)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   569 AA;  65330 MW;  31085C7EEEF9402A CRC64;
     MRKGRHMPRH TNANYARPGV SPNHPMFGRY LSTVGFPPAQ NVYNHWRHWY QPGHLWWTQP
     PQLQHPSSSF STVRHPFNRP PRPPDPYQWS SWRQTGVLPH TRGLHLSAGL MESTDRPPPQ
     KRRKSAEGEI SQRSPQHSPP KGSRSPKGSP EWLRNVSSIE VANRTSAVPE LKRHWEDLSH
     LCKAAPSVNR GKQKWPFDFS VMSYNILSQD LLCDNTYLYR HCNPPVLDWR NRFPNIIKEL
     EQYSADIMCL QEVQEDHYKQ QIKPSLESLG YHCEFKRRTG LKPDGCAVIF KRERFSLVSC
     HPVEYFRRGV PLMDRDNVGL IVLLRPIDPH VSLSNICVAN THLLYNPRRG DIKLAQLAML
     LAEISRVSQL PDSSVCPVLL CGDFNSVPWS PLYRFIKDRR LDYDGMPIGK VSGQEETPRG
     QRILTVPIWP RSLGISQQCQ YENQTRDSEL RDLEQTERES FTEASIEHCL RLTSAYSHHL
     KESGQPEITT CHSRTAITVD YIFYSAALGD VMAQAEYSAP PERGLQLLGR LALVGEKELQ
     KVNGLPNQHN SSDHLPLLTR FRLHPQADS