ANGE2_HUMAN
ID ANGE2_HUMAN Reviewed; 544 AA.
AC Q5VTE6; B7Z2U4; D3DTA3; Q86X13; Q8NHH3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein angel homolog 2;
GN Name=ANGEL2; Synonyms=KIAA0759L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Guo J.H., Yu L.;
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5VTE6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VTE6-2; Sequence=VSP_028216;
CC -!- SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47469.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF510741; AAM44053.1; -; mRNA.
DR EMBL; AK295116; BAH11980.1; -; mRNA.
DR EMBL; AL592449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471100; EAW93366.1; -; Genomic_DNA.
DR EMBL; CH471100; EAW93368.1; -; Genomic_DNA.
DR EMBL; CH471100; EAW93369.1; -; Genomic_DNA.
DR EMBL; BC047469; AAH47469.1; ALT_SEQ; mRNA.
DR CCDS; CCDS1512.1; -. [Q5VTE6-1]
DR CCDS; CCDS73027.1; -. [Q5VTE6-2]
DR RefSeq; NP_001287682.1; NM_001300753.1.
DR RefSeq; NP_001287684.1; NM_001300755.1.
DR RefSeq; NP_001287686.1; NM_001300757.1. [Q5VTE6-2]
DR RefSeq; NP_001287687.1; NM_001300758.1. [Q5VTE6-2]
DR RefSeq; NP_653168.2; NM_144567.4. [Q5VTE6-1]
DR PDB; 6RVZ; X-ray; 2.10 A; A=119-544.
DR PDB; 6RW0; X-ray; 1.45 A; A=119-544.
DR PDBsum; 6RVZ; -.
DR PDBsum; 6RW0; -.
DR AlphaFoldDB; Q5VTE6; -.
DR SMR; Q5VTE6; -.
DR BioGRID; 124763; 74.
DR IntAct; Q5VTE6; 19.
DR STRING; 9606.ENSP00000355929; -.
DR GlyGen; Q5VTE6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5VTE6; -.
DR PhosphoSitePlus; Q5VTE6; -.
DR BioMuta; ANGEL2; -.
DR DMDM; 74746929; -.
DR EPD; Q5VTE6; -.
DR jPOST; Q5VTE6; -.
DR MassIVE; Q5VTE6; -.
DR MaxQB; Q5VTE6; -.
DR PaxDb; Q5VTE6; -.
DR PeptideAtlas; Q5VTE6; -.
DR PRIDE; Q5VTE6; -.
DR ProteomicsDB; 65323; -. [Q5VTE6-1]
DR ProteomicsDB; 65324; -. [Q5VTE6-2]
DR Antibodypedia; 34614; 104 antibodies from 23 providers.
DR DNASU; 90806; -.
DR Ensembl; ENST00000360506.6; ENSP00000353696.2; ENSG00000174606.14. [Q5VTE6-2]
DR Ensembl; ENST00000366962.8; ENSP00000355929.3; ENSG00000174606.14. [Q5VTE6-1]
DR Ensembl; ENST00000535388.2; ENSP00000438141.2; ENSG00000174606.14. [Q5VTE6-2]
DR GeneID; 90806; -.
DR KEGG; hsa:90806; -.
DR MANE-Select; ENST00000366962.8; ENSP00000355929.3; NM_144567.5; NP_653168.2.
DR UCSC; uc001hjz.3; human. [Q5VTE6-1]
DR CTD; 90806; -.
DR DisGeNET; 90806; -.
DR GeneCards; ANGEL2; -.
DR HGNC; HGNC:30534; ANGEL2.
DR HPA; ENSG00000174606; Low tissue specificity.
DR MIM; 619001; gene.
DR neXtProt; NX_Q5VTE6; -.
DR OpenTargets; ENSG00000174606; -.
DR PharmGKB; PA142672620; -.
DR VEuPathDB; HostDB:ENSG00000174606; -.
DR eggNOG; KOG0620; Eukaryota.
DR eggNOG; KOG2338; Eukaryota.
DR GeneTree; ENSGT00940000157391; -.
DR HOGENOM; CLU_016428_0_2_1; -.
DR InParanoid; Q5VTE6; -.
DR OMA; WEYFCQQ; -.
DR PhylomeDB; Q5VTE6; -.
DR TreeFam; TF316126; -.
DR PathwayCommons; Q5VTE6; -.
DR SignaLink; Q5VTE6; -.
DR BioGRID-ORCS; 90806; 12 hits in 1074 CRISPR screens.
DR ChiTaRS; ANGEL2; human.
DR GenomeRNAi; 90806; -.
DR Pharos; Q5VTE6; Tbio.
DR PRO; PR:Q5VTE6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VTE6; protein.
DR Bgee; ENSG00000174606; Expressed in calcaneal tendon and 197 other tissues.
DR Genevisible; Q5VTE6; HS.
DR GO; GO:0015030; C:Cajal body; IDA:HGNC.
DR GO; GO:0005737; C:cytoplasm; IDA:HGNC.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:HGNC.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IMP:HGNC.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IMP:HGNC.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR045816; ANGEL2_N.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR Pfam; PF19339; DUF5922; 2.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Reference proteome.
FT CHAIN 1..544
FT /note="Protein angel homolog 2"
FT /id="PRO_0000305080"
FT VAR_SEQ 1..169
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_028216"
FT VARIANT 97
FT /note="P -> S (in dbSNP:rs11542154)"
FT /id="VAR_050290"
FT STRAND 135..137
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 164..173
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 177..182
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 183..187
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 192..195
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 197..211
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 214..222
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 223..228
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 230..236
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 239..245
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 247..249
FT /evidence="ECO:0007829|PDB:6RVZ"
FT STRAND 252..259
FT /evidence="ECO:0007829|PDB:6RW0"
FT TURN 260..262
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 263..272
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 286..294
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 304..310
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 318..335
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 341..343
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 346..351
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 359..366
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 367..370
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 376..378
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 394..397
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 399..401
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 407..409
FT /evidence="ECO:0007829|PDB:6RVZ"
FT STRAND 444..446
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 451..454
FT /evidence="ECO:0007829|PDB:6RW0"
FT TURN 460..462
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 467..471
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 474..476
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 479..484
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 505..510
FT /evidence="ECO:0007829|PDB:6RW0"
FT HELIX 515..520
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 523..525
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 531..533
FT /evidence="ECO:0007829|PDB:6RW0"
FT STRAND 536..543
FT /evidence="ECO:0007829|PDB:6RW0"
SQ SEQUENCE 544 AA; 62339 MW; 89F33A8A357E10A7 CRC64;
MEAWRCVRKG YGHCVVGRGR YPMFPHHSRS LGRDWTTPWE NLQRCCWNRH ISSCMRWPGH
YSRAPYPYFS SRHFSLNWRP PCLFESRTQF QYCNWRPDNL SQTSLIHLSS YVMNAEGDEP
SSKRRKHQGV IKRNWEYICS HDKEKTKILG DKNVDPKCED SENKFDFSVM SYNILSQDLL
EDNSHLYRHC RRPVLHWSFR FPNILKEIKH FDADVLCLQE VQEDHYGAEI RPSLESLGYH
CEYKMRTGRK PDGCAICFKH SKFSLLSVNP VEFFRPDISL LDRDNVGLVL LLQPKIPYAA
CPAICVANTH LLYNPRRGDI KLTQLAMLLA EISSVAHQKD GSFCPIVMCG DFNSVPGSPL
YSFIKEGKLN YEGLPIGKVS GQEQSSRGQR ILSIPIWPPN LGISQNCVYE VQQVPKVEKT
DSDLTQTQLK QTEVLVTAEK LSSNLQHHFS LSSVYSHYFP DTGIPEVTTC HSRSAITVDY
IFYSAEKEDV AGHPGAEVAL VGGLKLLARL SLLTEQDLWT VNGLPNENNS SDHLPLLAKF
RLEL
