ANGE2_MOUSE
ID ANGE2_MOUSE Reviewed; 544 AA.
AC Q8K1C0; Q3TEH1; Q3TL94; Q8BTT0; Q9JJB0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein angel homolog 2;
GN Name=Angel2; Synonyms=D1Ertd396e, D1Ertd654e; ORFNames=MNCb-4273;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Egg, Thymus, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8K1C0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K1C0-2; Sequence=VSP_028218;
CC Name=3;
CC IsoId=Q8K1C0-3; Sequence=VSP_028217;
CC Name=4;
CC IsoId=Q8K1C0-4; Sequence=VSP_028217, VSP_028220, VSP_028221;
CC Name=5;
CC IsoId=Q8K1C0-5; Sequence=VSP_028217, VSP_028219, VSP_028221;
CC -!- SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000305}.
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DR EMBL; AB041602; BAA95085.1; -; mRNA.
DR EMBL; AK088834; BAC40602.1; -; mRNA.
DR EMBL; AK135709; BAE22620.1; -; mRNA.
DR EMBL; AK158731; BAE34634.1; -; mRNA.
DR EMBL; AK166619; BAE38898.1; -; mRNA.
DR EMBL; AK169653; BAE41277.1; -; mRNA.
DR EMBL; BC024907; AAH24907.1; -; mRNA.
DR CCDS; CCDS15612.1; -. [Q8K1C0-1]
DR CCDS; CCDS56667.1; -. [Q8K1C0-2]
DR RefSeq; NP_001185949.1; NM_001199020.1. [Q8K1C0-2]
DR RefSeq; NP_067396.3; NM_021421.4. [Q8K1C0-1]
DR RefSeq; XP_006497246.1; XM_006497183.3. [Q8K1C0-2]
DR RefSeq; XP_006497247.1; XM_006497184.3. [Q8K1C0-2]
DR RefSeq; XP_006497248.1; XM_006497185.1.
DR AlphaFoldDB; Q8K1C0; -.
DR SMR; Q8K1C0; -.
DR BioGRID; 206609; 1.
DR STRING; 10090.ENSMUSP00000064556; -.
DR iPTMnet; Q8K1C0; -.
DR PhosphoSitePlus; Q8K1C0; -.
DR SwissPalm; Q8K1C0; -.
DR EPD; Q8K1C0; -.
DR MaxQB; Q8K1C0; -.
DR PaxDb; Q8K1C0; -.
DR PeptideAtlas; Q8K1C0; -.
DR PRIDE; Q8K1C0; -.
DR ProteomicsDB; 282097; -. [Q8K1C0-1]
DR ProteomicsDB; 282098; -. [Q8K1C0-2]
DR ProteomicsDB; 282099; -. [Q8K1C0-3]
DR ProteomicsDB; 282100; -. [Q8K1C0-4]
DR ProteomicsDB; 282101; -. [Q8K1C0-5]
DR Antibodypedia; 34614; 104 antibodies from 23 providers.
DR DNASU; 52477; -.
DR Ensembl; ENSMUST00000027947; ENSMUSP00000027947; ENSMUSG00000026634. [Q8K1C0-2]
DR Ensembl; ENSMUST00000066632; ENSMUSP00000064556; ENSMUSG00000026634. [Q8K1C0-1]
DR Ensembl; ENSMUST00000110899; ENSMUSP00000106524; ENSMUSG00000026634. [Q8K1C0-2]
DR Ensembl; ENSMUST00000123384; ENSMUSP00000117912; ENSMUSG00000026634. [Q8K1C0-5]
DR GeneID; 52477; -.
DR KEGG; mmu:52477; -.
DR UCSC; uc007ebj.2; mouse. [Q8K1C0-1]
DR CTD; 90806; -.
DR MGI; MGI:1196310; Angel2.
DR VEuPathDB; HostDB:ENSMUSG00000026634; -.
DR eggNOG; KOG0620; Eukaryota.
DR eggNOG; KOG2338; Eukaryota.
DR GeneTree; ENSGT00940000157391; -.
DR HOGENOM; CLU_016428_0_2_1; -.
DR InParanoid; Q8K1C0; -.
DR OMA; WEYFCQQ; -.
DR OrthoDB; 724242at2759; -.
DR PhylomeDB; Q8K1C0; -.
DR TreeFam; TF316126; -.
DR BioGRID-ORCS; 52477; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Angel2; mouse.
DR PRO; PR:Q8K1C0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8K1C0; protein.
DR Bgee; ENSMUSG00000026634; Expressed in rostral migratory stream and 264 other tissues.
DR ExpressionAtlas; Q8K1C0; baseline and differential.
DR Genevisible; Q8K1C0; MM.
DR GO; GO:0015030; C:Cajal body; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; ISO:MGI.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; ISO:MGI.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISO:MGI.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR045816; ANGEL2_N.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR Pfam; PF19339; DUF5922; 2.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..544
FT /note="Protein angel homolog 2"
FT /id="PRO_0000305081"
FT VAR_SEQ 1..169
FT /note="Missing (in isoform 3, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_028217"
FT VAR_SEQ 1..22
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028218"
FT VAR_SEQ 379..381
FT /note="VSG -> TVM (in isoform 5)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_028219"
FT VAR_SEQ 381
FT /note="G -> A (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028220"
FT VAR_SEQ 382..544
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_028221"
SQ SEQUENCE 544 AA; 62413 MW; BACD667CD222A52F CRC64;
METWRCVRRG YGRCVAGRGR YSMFPYPLKS LGRDWTTPWE DLQKYCWRRH ISSCLRWPGH
YSRAPYPYFS SRHFSLNCRP PFLFESGTQF QYYNWRSDHL SNASLIHLSR HVMTSDRDEP
LSKRRKHQGT IKRNWEYLCS HNKENTKDLE DRNVDSTCED REDKFDFSVM SYNILSQDLL
EDNSHLYRHC RRPVLHWSFR FPNILKEIKH FDADVLCLQE VQEDHYGTEI RPSLESLGYH
CEYKMKTGRK PDGCAICFKH SRFSLLSVNP VEFCRRDIPL LDRDNIGLVL LLQPKIPRAA
SPSICIANTH LLYNPRRGDI KLTQLAMLLA EIANVTHRKD GSSCPIVMCG DFNSVPGSPL
YSFIKEGKLN YEGLAIGKVS GQEQSSRGQR ILSIPIWPPN LGISQNCVYE AQQVPKVEKT
DSDVTQAQQE KAEVPVSADK VSSHLQHGFS LSSVYSHYVP DTGVPEVTTC HSRSAITVDY
IFYTAKKENT AQGPGAEVAL VGGLKLLARL SLLTEQDLWT VNGLPNEHNS SDHLPLLAKF
RLEL
