ANGEL_DROME
ID ANGEL_DROME Reviewed; 354 AA.
AC Q24239; Q9W1L3;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2001, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein angel;
DE AltName: Full=Angel 39;
DE Short=ANG39;
GN Name=angel; ORFNames=CG12273;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC STRAIN=Oregon-R; TISSUE=Embryo;
RX PubMed=8809105; DOI=10.1016/0167-4781(96)00108-x;
RA Kurzik-Dumke U., Zengerle A.;
RT "Identification of a novel Drosophila melanogaster gene, angel, a member of
RT a nested gene cluster at locus 59F4,5.";
RL Biochim. Biophys. Acta 1308:177-181(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed in embryos.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development, highest
CC expression seen in second instar larvae, pupae and adults.
CC -!- SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000305}.
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DR EMBL; X85743; CAA59746.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF47045.1; -; Genomic_DNA.
DR EMBL; AY058301; AAL13530.1; -; mRNA.
DR PIR; S71925; S71925.
DR RefSeq; NP_477204.1; NM_057856.5.
DR AlphaFoldDB; Q24239; -.
DR SMR; Q24239; -.
DR BioGRID; 63346; 4.
DR DIP; DIP-17505N; -.
DR IntAct; Q24239; 1.
DR STRING; 7227.FBpp0071992; -.
DR PaxDb; Q24239; -.
DR DNASU; 37748; -.
DR EnsemblMetazoa; FBtr0072083; FBpp0071992; FBgn0016762.
DR GeneID; 37748; -.
DR KEGG; dme:Dmel_CG12273; -.
DR UCSC; CG12273-RA; d. melanogaster.
DR CTD; 37748; -.
DR FlyBase; FBgn0016762; angel.
DR VEuPathDB; VectorBase:FBgn0016762; -.
DR eggNOG; KOG2338; Eukaryota.
DR GeneTree; ENSGT00940000169613; -.
DR HOGENOM; CLU_016428_0_0_1; -.
DR InParanoid; Q24239; -.
DR OMA; HYLGSDH; -.
DR OrthoDB; 704519at2759; -.
DR PhylomeDB; Q24239; -.
DR BioGRID-ORCS; 37748; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 37748; -.
DR PRO; PR:Q24239; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0016762; Expressed in oviduct (Drosophila) and 21 other tissues.
DR Genevisible; Q24239; DM.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..354
FT /note="Protein angel"
FT /id="PRO_0000218572"
FT REGION 22..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 37
FT /note="A -> T (in Ref. 1; CAA59746)"
FT /evidence="ECO:0000305"
FT CONFLICT 353
FT /note="V -> A (in Ref. 1; CAA59746)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 354 AA; 40306 MW; 1AABE3F3F393C56B CRC64;
MYRSLLHNVS LKATSRIIRR SVSSQAKGAS GKRKQKAKEM ESSHDRNRRW TSLGNQAEGR
DPHKCSSFKV VSYNILAQDL LLEHLFLYVG IPHEFLSWQR RQQNLLRELL KLDPDILCLQ
EMQFDHLPVL VQRLRMGNGK KLAYVYKKKT GCRTDGCAIV YDSSKFELLD HQAVELYDQA
VALLNRDNVA LFARFRFKKQ QEQQKEFVVA TTHLLFNTKR SDVRCAQVER ILEELQSFST
DTPIVLTGDF NSLPDSSPIE FLVGKNGDVD STACPEPLHF EIIDSGEGTA STYQNEWVIV
DYILRSLGSR SRHKLLPLSV YSLPSINRCI GAGQIPNYRL GSDHYALGAV FTVV
