ID   ANGL1_BOVIN             Reviewed;         491 AA.
AC   Q1RMR1; B2Z4A9;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Angiopoietin-related protein 1;
DE   AltName: Full=Angiopoietin-like protein 1;
DE   Flags: Precursor;
GN   Name=ANGPTL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA   Shui Y.;
RT   "Genomic structure of Bos taurus angiopoietin-like proteins.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; EU599224; ACD50900.1; -; mRNA.
DR   EMBL; EU599231; ACD50907.1; -; Genomic_DNA.
DR   EMBL; BC114763; AAI14764.1; -; mRNA.
DR   RefSeq; NP_001068894.1; NM_001075426.1.
DR   RefSeq; XP_015330623.1; XM_015475137.1.
DR   AlphaFoldDB; Q1RMR1; -.
DR   SMR; Q1RMR1; -.
DR   STRING; 9913.ENSBTAP00000014193; -.
DR   PaxDb; Q1RMR1; -.
DR   Ensembl; ENSBTAT00000014193; ENSBTAP00000014193; ENSBTAG00000010719.
DR   GeneID; 509971; -.
DR   KEGG; bta:509971; -.
DR   CTD; 9068; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010719; -.
DR   VGNC; VGNC:25890; ANGPTL1.
DR   eggNOG; KOG2579; Eukaryota.
DR   GeneTree; ENSGT00940000155091; -.
DR   HOGENOM; CLU_038628_0_0_1; -.
DR   InParanoid; Q1RMR1; -.
DR   OMA; RDKDMYT; -.
DR   OrthoDB; 525245at2759; -.
DR   TreeFam; TF336658; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000010719; Expressed in intramuscular adipose tissue and 100 other tissues.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 3.90.215.10; -; 1.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..491
FT                   /note="Angiopoietin-related protein 1"
FT                   /id="PRO_0000278837"
FT   DOMAIN          271..491
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   COILED          80..168
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        280..309
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   DISULFID        432..445
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
SQ   SEQUENCE   491 AA;  56674 MW;  5275247C15D3FB2F CRC64;
     MKAFIWTLSV LFFLLMGIGH GRGRQFKIKK ITQRRYPRAT DGKEDAKKCS YTFLVPEQKI
     TGPICVNTKG QDAGTIKDMI TRMDLENLKD VLSKQKREID VLQLVVDVDG NIVNEVKLLR
     KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA
     SLTDLVNNQS VMITLLEEQC LRIFSRQDPH VSPPLVQVVP QHIPNSHQYT PGLLGGNEIQ
     RDPGYPRDLM PPPDLVTSPT KSPLKIPPVT FINEGPYKDC QHAKDAGHSV SGIYMIKPEN
     SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYLLS
     NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT
     LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKYQDGIFW AEYRGGSYSL
     RAVQMLIKPI D