ANGL1_HUMAN
ID ANGL1_HUMAN Reviewed; 491 AA.
AC O95841; Q5T5Z5;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Angiopoietin-related protein 1;
DE AltName: Full=Angiopoietin-3;
DE Short=ANG-3;
DE AltName: Full=Angiopoietin-like protein 1;
DE Flags: Precursor;
GN Name=ANGPTL1; Synonyms=ANG3, ANGPT3, ARP1;
GN ORFNames=PSEC0154, UNQ162/PRO188;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Heart;
RX PubMed=10025962; DOI=10.1016/s0014-5793(99)00008-3;
RA Kim I., Kwak H.J., Ahn J.E., So J.-N., Liu M., Koh K.N., Koh G.Y.;
RT "Molecular cloning and characterization of a novel angiopoietin family
RT protein, angiopoietin-3.";
RL FEBS Lett. 443:353-356(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10025962}.
CC -!- TISSUE SPECIFICITY: Highly expressed in adrenal gland, placenta,
CC thyroid gland, heart, skeletal muscle and small intestine. Weakly
CC expressed in testis, ovary, colon, pancreas, kidney and stomach.
CC {ECO:0000269|PubMed:10025962}.
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DR EMBL; AF107253; AAD19608.1; -; mRNA.
DR EMBL; AY358278; AAQ88645.1; -; mRNA.
DR EMBL; AB056476; BAB40691.1; -; mRNA.
DR EMBL; AL355520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050640; AAH50640.1; -; mRNA.
DR CCDS; CCDS1327.1; -.
DR RefSeq; NP_004664.1; NM_004673.3.
DR RefSeq; XP_005245634.1; XM_005245577.2.
DR AlphaFoldDB; O95841; -.
DR SMR; O95841; -.
DR STRING; 9606.ENSP00000234816; -.
DR GlyGen; O95841; 2 sites.
DR iPTMnet; O95841; -.
DR PhosphoSitePlus; O95841; -.
DR BioMuta; ANGPTL1; -.
DR EPD; O95841; -.
DR jPOST; O95841; -.
DR MassIVE; O95841; -.
DR PaxDb; O95841; -.
DR PeptideAtlas; O95841; -.
DR PRIDE; O95841; -.
DR ProteomicsDB; 51085; -.
DR Antibodypedia; 1217; 420 antibodies from 30 providers.
DR DNASU; 9068; -.
DR Ensembl; ENST00000234816.7; ENSP00000234816.2; ENSG00000116194.13.
DR Ensembl; ENST00000367629.1; ENSP00000356601.1; ENSG00000116194.13.
DR GeneID; 9068; -.
DR KEGG; hsa:9068; -.
DR MANE-Select; ENST00000234816.7; ENSP00000234816.2; NM_004673.4; NP_004664.1.
DR UCSC; uc001gma.4; human.
DR CTD; 9068; -.
DR DisGeNET; 9068; -.
DR GeneCards; ANGPTL1; -.
DR HGNC; HGNC:489; ANGPTL1.
DR HPA; ENSG00000116194; Tissue enhanced (placenta).
DR MIM; 603874; gene.
DR neXtProt; NX_O95841; -.
DR OpenTargets; ENSG00000116194; -.
DR PharmGKB; PA24794; -.
DR VEuPathDB; HostDB:ENSG00000116194; -.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000155091; -.
DR HOGENOM; CLU_038628_0_0_1; -.
DR InParanoid; O95841; -.
DR OMA; RDKDMYT; -.
DR OrthoDB; 525245at2759; -.
DR PhylomeDB; O95841; -.
DR TreeFam; TF336658; -.
DR PathwayCommons; O95841; -.
DR SignaLink; O95841; -.
DR SIGNOR; O95841; -.
DR BioGRID-ORCS; 9068; 10 hits in 1075 CRISPR screens.
DR ChiTaRS; ANGPTL1; human.
DR GeneWiki; ANGPTL1; -.
DR GenomeRNAi; 9068; -.
DR Pharos; O95841; Tbio.
DR PRO; PR:O95841; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O95841; protein.
DR Bgee; ENSG00000116194; Expressed in left uterine tube and 157 other tissues.
DR ExpressionAtlas; O95841; baseline and differential.
DR Genevisible; O95841; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; -; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..491
FT /note="Angiopoietin-related protein 1"
FT /id="PRO_0000009118"
FT DOMAIN 271..491
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT COILED 80..168
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 280..309
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT DISULFID 432..445
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
SQ SEQUENCE 491 AA; 56720 MW; 3C4DB8DEF6CF7E99 CRC64;
MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA YTFLVPEQRI
TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID VLQLVVDVDG NIVNEVKLLR
KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA
SLTDLVNNQS VMITLLEEQC LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ
RDPGYPRDLM PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN
SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYMLS
NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT
LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL
RAVQMMIKPI D
