ANGL1_MOUSE
ID ANGL1_MOUSE Reviewed; 490 AA.
AC Q640P2; Q3UQL1; Q9CZ81;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Angiopoietin-related protein 1;
DE AltName: Full=Angiopoietin-like protein 1;
DE Flags: Precursor;
GN Name=Angptl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q640P2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q640P2-2; Sequence=VSP_013722, VSP_013723;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB28537.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK012888; BAB28537.1; ALT_SEQ; mRNA.
DR EMBL; AK142319; BAE25028.1; -; mRNA.
DR EMBL; BC082563; AAH82563.1; -; mRNA.
DR CCDS; CCDS15397.1; -. [Q640P2-1]
DR RefSeq; NP_082609.2; NM_028333.2. [Q640P2-1]
DR AlphaFoldDB; Q640P2; -.
DR SMR; Q640P2; -.
DR STRING; 10090.ENSMUSP00000027885; -.
DR GlyGen; Q640P2; 2 sites.
DR iPTMnet; Q640P2; -.
DR PhosphoSitePlus; Q640P2; -.
DR MaxQB; Q640P2; -.
DR PaxDb; Q640P2; -.
DR PeptideAtlas; Q640P2; -.
DR PRIDE; Q640P2; -.
DR ProteomicsDB; 282102; -. [Q640P2-1]
DR ProteomicsDB; 282103; -. [Q640P2-2]
DR Antibodypedia; 1217; 420 antibodies from 30 providers.
DR DNASU; 72713; -.
DR Ensembl; ENSMUST00000027885; ENSMUSP00000027885; ENSMUSG00000033544. [Q640P2-1]
DR Ensembl; ENSMUST00000111720; ENSMUSP00000107349; ENSMUSG00000033544. [Q640P2-2]
DR GeneID; 72713; -.
DR KEGG; mmu:72713; -.
DR UCSC; uc007ddc.1; mouse. [Q640P2-2]
DR UCSC; uc007ddd.2; mouse. [Q640P2-1]
DR CTD; 9068; -.
DR MGI; MGI:1919963; Angptl1.
DR VEuPathDB; HostDB:ENSMUSG00000033544; -.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000155091; -.
DR HOGENOM; CLU_038628_0_0_1; -.
DR InParanoid; Q640P2; -.
DR OMA; RDKDMYT; -.
DR OrthoDB; 525245at2759; -.
DR PhylomeDB; Q640P2; -.
DR TreeFam; TF336658; -.
DR BioGRID-ORCS; 72713; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Angptl1; mouse.
DR PRO; PR:Q640P2; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q640P2; protein.
DR Bgee; ENSMUSG00000033544; Expressed in jaw mesenchyme and 154 other tissues.
DR Genevisible; Q640P2; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IPI:MGI.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IPI:MGI.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; -; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..490
FT /note="Angiopoietin-related protein 1"
FT /id="PRO_0000009119"
FT DOMAIN 270..490
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT COILED 79..167
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 279..308
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT DISULFID 431..444
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT VAR_SEQ 275..323
FT /note="PFKDCQQAKEAGHSASGIYMIKPENSNGLMQLWCENSLDPGGWTVIQKR ->
FT ELLLPGQWKNEAGMLMLYDSRNNTLILVSPTSYVLMPLYMSNQNFHFLK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013722"
FT VAR_SEQ 324..490
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013723"
SQ SEQUENCE 490 AA; 56323 MW; 1A870A092C96EF97 CRC64;
MKAFVWTLSV LLFLLGSGHC KGGQLKIKKI TQRRYPRATD GKEEAKKCSY TFLVPEQKIT
GPICVNTKGQ DAGTIKDMIT RMDLENLKDV LSRQKREIDV LQLVVDVDGN IVNEVKLLRK
ESRNMNSRVT QLYMQLLHEI IRKRDNSLEL SQLENKILNV TTEMLKMATR YRELEVKYAS
LTDLVNNQSV TITVLEEQCL RMFSRQDPHA SPPLVQVVPR HSPNSHQYTP GLLGGNEIQR
DPGYPRDVMP PPDLPTAPTK SPFKIPAVTF INEGPFKDCQ QAKEAGHSAS GIYMIKPENS
NGLMQLWCEN SLDPGGWTVI QKRTDGSVNF FRNWENYKKG FGNIDGEYWL GLDNIYKLSN
QDNYKLMIEL EDWSEKKVYA EYSSFRLEPE SDYYRLRLGT YQGNAGDSMM WHNGKQFTTL
DRDKDTYTGN CAHFHKGGWW YNACAHSNLN GVWYRGGHYR SKHQDGIFWA EYRGGSYSLR
AVQMMIKPID
