ANGL2_MOUSE
ID ANGL2_MOUSE Reviewed; 493 AA.
AC Q9R045; Q8BM09;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Angiopoietin-related protein 2;
DE AltName: Full=Angiopoietin-like protein 2;
DE Flags: Precursor;
GN Name=Angptl2; Synonyms=Arp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RX PubMed=10473614; DOI=10.1074/jbc.274.37.26523;
RA Kim I., Moon S.-O., Koh K.N., Kim H., Uhm C.-S., Kwak H.J., Kim N.-G.,
RA Koh G.Y.;
RT "Molecular cloning, expression, and characterization of angiopoietin-
RT related protein. angiopoietin-related protein induces endothelial cell
RT sprouting.";
RL J. Biol. Chem. 274:26523-26528(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Induces sprouting in endothelial cells through an autocrine
CC and paracrine action. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed in heart, tongue, lung and
CC skeletal muscle. Also found in lower levels in kidney, epididymis and
CC testis.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF125176; AAD55358.1; -; mRNA.
DR EMBL; AK037265; BAC29780.1; -; mRNA.
DR EMBL; AK155464; BAE33276.1; -; mRNA.
DR EMBL; AL845277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466542; EDL08597.1; -; Genomic_DNA.
DR EMBL; BC138609; AAI38610.1; -; mRNA.
DR EMBL; BC138610; AAI38611.1; -; mRNA.
DR CCDS; CCDS15940.1; -.
DR RefSeq; NP_036053.2; NM_011923.4.
DR RefSeq; XP_006498114.1; XM_006498051.1.
DR AlphaFoldDB; Q9R045; -.
DR SMR; Q9R045; -.
DR BioGRID; 204920; 3.
DR STRING; 10090.ENSMUSP00000004208; -.
DR GlyGen; Q9R045; 2 sites.
DR iPTMnet; Q9R045; -.
DR PhosphoSitePlus; Q9R045; -.
DR MaxQB; Q9R045; -.
DR PaxDb; Q9R045; -.
DR PeptideAtlas; Q9R045; -.
DR PRIDE; Q9R045; -.
DR ProteomicsDB; 282104; -.
DR Antibodypedia; 30639; 306 antibodies from 31 providers.
DR DNASU; 26360; -.
DR Ensembl; ENSMUST00000004208; ENSMUSP00000004208; ENSMUSG00000004105.
DR GeneID; 26360; -.
DR KEGG; mmu:26360; -.
DR UCSC; uc008jhq.1; mouse.
DR CTD; 23452; -.
DR MGI; MGI:1347002; Angptl2.
DR VEuPathDB; HostDB:ENSMUSG00000004105; -.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000155946; -.
DR HOGENOM; CLU_038628_0_0_1; -.
DR InParanoid; Q9R045; -.
DR OMA; CVTYWWL; -.
DR OrthoDB; 525245at2759; -.
DR PhylomeDB; Q9R045; -.
DR TreeFam; TF336658; -.
DR BioGRID-ORCS; 26360; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q9R045; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9R045; protein.
DR Bgee; ENSMUSG00000004105; Expressed in tarsal region and 229 other tissues.
DR ExpressionAtlas; Q9R045; baseline and differential.
DR Genevisible; Q9R045; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; -; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..493
FT /note="Angiopoietin-related protein 2"
FT /id="PRO_0000009121"
FT DOMAIN 269..489
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT COILED 77..115
FT /evidence="ECO:0000255"
FT COILED 152..202
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 278..307
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT DISULFID 430..443
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT CONFLICT 490..491
FT /note="NT -> DI (in Ref. 1; AAD55358)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 493 AA; 57105 MW; 22884B4010746BF2 CRC64;
MRPLCMTYWW LGLLATVGAA TGPEADVEGT EDGSQREYIY LNRYKRAGES PDKCTYTFIV
PQQRVTGAIC VNSKEPEVHL ENRVHKQELE LLNNELLKQK RQIETLQQLV EVDGGIVSEV
KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD NALELSQLEN RILNQTADML QLASKYKDLE
HKFQHLAMLA HNQSEVIAQL EEHCQRVPAA RPMPQPPPAA PPRVYQPPTY NRIINQISTN
EIQSDQNLKV LPPSLPTMPA LTSLPSSTDK PSGPWRDCLQ ALEDGHSTSS IYLVKPENTN
RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG LENIYWLTNQ
GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY HGNAGDSFTW HNGKQFTTLD
RDHDVYTGNC AHYQKGGWWY NACAHSNLNG VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK
VVMMIRPNPN TFH
